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Lactose sensitivity and lactose malabsorption. The two faces of lactose intolerance.

Abstract：

Background/Aims:Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of FBD patients without small intestinal bacterial overgrowth (SIBO), and LI, in terms of lactose malabsorption (LM) and lactose sensitivity (LS) according to psychological and clinical features. Methods:One hundred and fifty-eight consecutive FBD outpatients with LI, and no SIBO, were classified according to the Rome III questionnaire and filled Beck Depression Inventory, and State and Trait Anxiety questionnaires. They underwent a lactose test in which glycemia during 60 minutes and digestive symptoms during 3 hours were recorded. Results:Abnormal lactose tests were found in 110 patients (70%), 44 (28%) with LM, 96 (61%) with LS, and 30 (19%) having both LM and LS. LM patients had a higher frequency of functional diarrhea (P = 0.040) and a lower frequency of dysphagia (P = 0.031). LS patients had a higher depression score (P = 0.007), higher frequency of globus (P = 0.042), irritable bowel syndrome (IBS) (P = 0.027) and mixed IBS (P = 0.049), and lower frequency of abdominal pain (P = 0.040). LS was significantly associated with higher depression score (P = 0.002), and higher frequency of globus (P = 0.046). Conclusions:Thirty percent of LI patients have normal lactose absorption and normal LS. In the other 70% of patients, LI could be associated with LM and/or LS.

journal_name

J Neurogastroenterol Motil

journal_title

Journal of neurogastroenterology and motility

authors

Bouchoucha M,Fysekidis M,Rompteaux P,Raynaud JJ,Sabate JM,Benamouzig R

doi

10.5056/jnm20094

subject

Has Abstract

pub_date

2020-12-28 00:00:00

eissn

2093-0879

issn

2093-0887

pii

jnm20094

pub_type

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