Abstract:
INTRODUCTION:MS is associated with structural and functional brain alterations leading to cognitive impairments across multiple domains including attention, memory, and speed of information processing. Here, we analyzed the white matter damage and topological organization of white matter tracts in specific brain regions responsible for cognition in MS. METHODS:Brain DTI, rs-fMRI, T1, T2, and T2-FLAIR were acquired for 22 MS subjects and 22 healthy controls. Automatic brain parcellation was performed on T1-weighted images. Skull-stripped T1-weighted intensity inverted images were co-registered to the b0 image. Diffusion-weighted images were processed to perform whole brain tractography. The rs-fMRI data were processed, and the connectivity matrixes were analyzed to identify significant differences in the network of nodes between the two groups using NBS analysis. In addition, diffusion entropy maps were produced from DTI data sets using in-house software. RESULTS:MS subjects exhibited significantly reduced mean FA and entropy in 38 and 34 regions, respectively, out of a total of 54 regions. The connectivity values in both structural and functional analyses were decreased in most regions of the default mode network and in four other cognitive networks in MS subjects compared to healthy controls. MS also induced significant reduction in the normalized hippocampus and corpus callosum volumes; the normalized hippocampus volume was significantly correlated with EDSS scores. CONCLUSION:MS subjects have significant white matter damage and reduction of FA and entropy in various brain regions involved in cognitive networks. Structural and functional connectivity within the default mode network and an additional four cognitive networks exhibited significant changes compared with healthy controls.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Lashkari A,Davoodi-Bojd E,Fahmy L,Li L,Nejad-Davarani SP,Chopp M,Jiang Q,Cerghet Mdoi
10.1016/j.clineuro.2020.106424subject
Has Abstractpub_date
2020-12-08 00:00:00pages
106424eissn
0303-8467issn
1872-6968pii
S0303-8467(20)30767-8journal_volume
201pub_type
杂志文章abstract:PURPOSE:To analyze sagittal balance of the cervical spine after three operative methods for three consecutive levels. METHODS:A retrospective case selection and observational study was performed from December 2012 to December 2015: 20 patients underwent anterior cervical discectomy and fusion, 22 patients underwent hy...
journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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更新日期:1986-01-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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pub_type: 杂志文章,评审
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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更新日期:2018-10-01 00:00:00