Abstract:
BACKGROUND AND AIMS:Our objective was to study relationships between the new biomarker of vascular health, carotid artery longitudinal wall motion (CALM) and metabolic syndrome (MetS). METHODS:Carotid ultrasound and assessment of MetS and its components were performed with 281 subjects aged 30-45 years. In the longitudinal motion analysis, the amplitude of motion and the antegrade-oriented and retrograde-oriented components of motion between the intima-media complex and adventitial layer of the common carotid artery wall were assessed. RESULTS:Metabolic syndrome, according to the harmonized criteria, was detected in 53 subjects (19%). MetS was significantly associated with increased antegrade and decreased retrograde longitudinal motion in the carotid artery wall. Augmented antegrade amplitude of longitudinal motion was associated with obesity (β = 0.149, p < .05) and low HDL cholesterol (β = 0.177, p < .01). Attenuated retrograde amplitude of longitudinal motion was associated with hypertension (β = -0.156, p < .05), obesity (β = -0.138, p < .05) and hyperinsulinaemia (β = -0.158, p < .01). Moreover, insulin resistance (homeostasis model assessment index above 2.44) was associated with adverse changes in CALM. CONCLUSION:Metabolic syndrome and insulin resistance were associated with alterations in CALM. In particular, hypertension, obesity and hyperinsulinaemia were associated with reduced total peak-to-peak amplitude as well as increased antegrade and reduced retrograde amplitudes, all of which might be markers of unfavourable vascular health.
journal_name
Clin Physiol Funct Imagingjournal_title
Clinical physiology and functional imagingauthors
Taivainen SH,Laitinen TM,Yli-Ollila H,Juonala M,Kähönen M,Raitakari OT,Laitinen TPdoi
10.1111/cpf.12687subject
Has Abstractpub_date
2020-12-19 00:00:00eissn
1475-0961issn
1475-097Xpub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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