Abstract:
BACKGROUND:Binding to the angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter target cells. This enzyme is expressed in many human tissues including the lungs, but no research has demonstrated that SARS-CoV-2 can infect human skin or subcutaneous fat tissue, despite the increasing number of reported skin manifestations. The aim of this study was to investigate ACE2 gene expression in skin using a public database. METHODS:A search of transcriptomic data sets from a public gene expression database to investigate ACE2 gene expression in human tissues. RESULTS:Human skin keratinocytes and basal cells express more ACE2 than lung epithelial cells. In contrast, both fibroblasts and melanocytes from human skin express less ACE2 than human lung epithelial cells. CONCLUSIONS:The high expression of ACE2 in keratinocytes and basal cells of human skin indicates that they may be directly susceptible to SARS-CoV-2 infection via the ACE2 receptor, especially in conditions of skin barrier dysfunction, and are therefore a potential target for the coronavirus.
journal_name
Adv Skin Wound Carejournal_title
Advances in skin & wound careauthors
Al-Benna Sdoi
10.1097/01.ASW.0000722748.73437.7dsubject
Has Abstractpub_date
2021-01-01 00:00:00pages
31-35issue
1eissn
1527-7941issn
1538-8654pii
00129334-202101000-00005journal_volume
34pub_type
杂志文章abstract:BACKGROUND:Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE:To compare NCS with vacuum-assisted clos...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000547411.16017.58
更新日期:2019-01-01 00:00:00
abstract::The heel is the second most common area where patients develop pressure ulcers (PrUs). Some of the interventions commonly used today to prevent PrUs have not been empirically tested, whereas other interventions have been studied and shown to prevent heel PrUs. Currently, there are no specific studies comparing a press...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000412909.81452.b6
更新日期:2012-03-01 00:00:00
abstract::The reverse sural adipofascial flap (RSAF) is used to reconstruct challenging wounds of the foot and ankle. It offers several advantages over the traditional reverse sural flap, including less venous congestion. To complete the reconstruction, split-thickness skin grafting (STSG) may be done immediately or in a delaye...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000527290.81581.af
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The goal of the present study was to evaluate the effects of hydroalcoholic extract-based carboxy methyl cellulose (CMC) gel of Punica granatum peel (PCMC) and CMC on healing of full-thickness skin wounds. MATERIALS AND METHODS:Forty-two rats were studied. Each rat had 3 wounds that were treated topically wi...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000481116.16998.55
更新日期:2016-05-01 00:00:00
abstract:GENERAL PURPOSE:The purpose of this learning activity is to provide information about the Healthy Foot Screen, a new tool for assessment of common foot abnormalities. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000530686.16243.d5
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Research suggests that active Leptospermum honey (ALH) improves outcomes in patients with partial-thickness burns by enhancing healing and reepithelialization rates, as well as by protecting against antibiotic-resistant microorganisms. This study assessed the effectiveness of ALH gel on healing time, bacteria...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000484666.83140.b0
更新日期:2016-08-01 00:00:00
abstract::Wound care professionals should carefully inspect and audit their coding and billing practices in light of (1) the OIG's 2014 Semiannual Report to Congress and (2) the 2015 OIG Work Plan.You can read the details of both documents by following the Internet links provided earlier in this article. Conducting those self-a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000459891.21303.0f
更新日期:2015-02-01 00:00:00
abstract:GENERAL PURPOSE:To present a systematic review of the literature assessing the efficacy of monitoring devices for reducing the risk of developing pressure injuries. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.ASW.0000504579.83707.f6
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Genital trauma during vaginal delivery may result from episiotomy, spontaneous perineal tears (perineum, vagina), or both. In 2012, this study aimed to investigate the effect of warm compress bistage intervention on the rate of episiotomy, perineal trauma, and postpartum pain intensity in the primiparous wom...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000476073.96442.91
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the efficacy of a wound support network model between the primary home care service and the hospital. The impact on wound healing rate, cost benefit, and transfer of knowledge was investigated. INTERVENTION:The intervention group was exposed to a wound support network (n = 3...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000499714.97688.4b
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Negative-pressure wound therapy (NPWT) is a mainstay in the treatment of acute and chronic wounds. Following the success of the Vacuum-Assisted Closure system (Kinetic Concepts Inc [KCI], an Acelity Company, San Antonio, Texas), many similar systems were developed with minor variations. However, these systems...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000481188.31032.52
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To compare the cytotoxicities and efficacy of hyaluronan (HA), carbomer, and sodium alginate on repairing thermal-injured cells and promoting cell migration. DESIGN:The 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetra-zoliumromide method was used to evaluate the cytotoxicities of HA, carbomer, and sodium a...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000467303.39079.59
更新日期:2015-09-01 00:00:00
abstract::Darier disease is an autosomal dominant skin disorder characterized by keratotic papules. After their appearance, these lesions tend to grow over time, producing large and exudative plaques that compromise the general condition of the affected patient's skin. The authors report the clinical case of a patient affected ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000694144.13825.59
更新日期:2020-10-01 00:00:00
abstract:GENERAL PURPOSE:To review what is known about pediatric pressure injuries (PIs) and the specific factors that make neonates and children vulnerable. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound ca...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000577124.58253.66
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To examine the effect of arginine supplementation on wound healing, as measured by wound size and healing rate, in older adults in acute and long-term care (LTC) settings. DATA SOURCES:PubMed, CINAHL Plus, Google Scholar, and OpenGrey databases. STUDY SELECTION:Randomized clinical trials and clinical studie...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000579700.20404.56
更新日期:2019-10-01 00:00:00
abstract::Laparoscopic bowel surgery has demonstrated patient care benefits of decreased duration of hospital stay, smaller incisions, lower risk of cardiopulmonary complications, and reduced risk of small-bowel obstruction. Resection of complicated diverticular disease and inflammatory bowel disease can be technically challeng...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/00129334-200211000-00009
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:The objective of this multicenter study was to prospectively evaluate the healing outcomes of chronic diabetic foot ulcers (DFUs) treated with PriMatrix (TEI Biosciences, Boston, Massachusetts), a fetal bovine acellular dermal matrix. METHODS:Inclusion criteria required the subjects to have a chronic DFU tha...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ASW.0000451891.87020.69
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinical role of a novel, noncontact, low-intensity, low-frequency ultrasound therapy (MIST Therapy) in the treatment of nonhealing leg and foot ulcers associated with chronic critical limb ischemia. DESIGN:Prospective, parallel-group, randomized, controlled trial. SETTING:A multidisciplinar...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000266660.88900.38
更新日期:2007-04-01 00:00:00
abstract:GENERAL PURPOSE:To present an evaluation of a surfactant-containing polymeric membrane foam wound dressing for use on patients with chronic pilonidal sinus disease. TARGET AUDIENCE:This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in s...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000534702.34915.90
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of different dressing methods on the wound healing process after pilonidal sinus surgery. METHODS:In this clinical trial, 60 patients undergoing pilonidal sinus surgery were randomly assigned to one of three groups. In the first group, hydrogel or alginate and hydrocolloid compounds we...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ASW.0000558268.59745.d2
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Bitter melon is a plant fruit that has been shown to exert a hypoglycemic effect when used systemically in patients with diabetes. This study was designed to investigate the topical effect of bitter melon on diabetic wounds using the wound chamber model in rats. DESIGN:Two bilateral wound chambers were impla...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000504758.86737.76
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether the Qoustic Wound Therapy System (Arobella Medical, LLC, Minnetonka, Minnesota) kills planktonic bacterial cells and/or removes bacterial biofilms. DESIGN:The Qoustic Wound Therapy System was evaluated against Pseudomonas aeruginosa, Staphylococcus epidermid...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000363557.45726.41
更新日期:2010-07-01 00:00:00
abstract::Bed positioning poses a subtle, yet important, tradeoff in the competing needs of hospitalized patients, particularly those susceptible to lower respiratory tract infections and/or pressure ulcers. Although it is widely held that a minimum 30° incline is necessary to mitigate risk of ventilator-acquired pneumonia, it ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000471877.19459.85
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To describe the dietary habits and anthropometric and biochemical parameters of patients with active venous leg ulcers and to verify the association of these variables with wound duration and area. DESIGN, SETTING, AND PARTICIPANTS:A cross-sectional study conducted with 33 participants diagnosed with venous ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000694160.19845.1b
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:Innovative skin substitutes and temporary wound dressings are frequently used in the treatment of superficial and partial-thickness wounds. The aim of this study was to compare 2 commonly used temporary skin dressings with a newly developed collagen matrix to determine changes in microcirculation as measured ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000525848.21221.b8
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence and risk factors of pressure injury (PI) development after ventricular assist device (VAD) or total artificial heart (TAH) surgery. METHODS:The investigator reviewed all VAD-TAH surgeries performed between 2010 and 2018 in a large academic health system. The PIs were reported by ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000717236.91761.78
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Scientific literature suggests pressure ulcer (PU) risk increases as immobility increases, indicating that more extensive paralysis confers a greater risk of PU. Yet the specific level of paralysis (ie, hemiplegia vs paraplegia vs quadriplegia), apart from neurodegenerative diagnoses, has never been examined ...
journal_title:Advances in skin & wound care
pub_type: 杂志文章
doi:10.1097/01.ASW.0000553109.70752.bf
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS:A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical tr...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000462328.60670.c3
更新日期:2015-04-01 00:00:00
abstract::Thromboangiitis obliterans, or Buerger disease, is a rare nonatherosclerotic segmental inflammatory vasculitis that generally affects young tobacco smokers. Although no surgical treatment is available, the most effective way to halt the disease's progress is smoking cessation. In this case report, a 29-year-old smoker...
journal_title:Advances in skin & wound care
pub_type: 杂志文章,评审
doi:10.1097/01.ASW.0000604192.77577.6f
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess and compare the efficacy of high-voltage electrical stimulation (HVES) with ultrasound (US) in treating Stage II through Stage IV pressure ulcers (PrUs)* of hospitalized patients. DESIGN:This study was designed as a prospective, controlled trial in which patients were rand...
journal_title:Advances in skin & wound care
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.ASW.0000526606.72489.99
更新日期:2017-12-01 00:00:00