Abstract：
:Gastric cancer (GC) is a deadly disease with poor prognosis that is characterized by heterogeneity. New classifications based on histologic features, genotypes, and molecular phenotypes, for example, the Cancer Genome Atlas subtypes and those by the Asian Cancer Research Group, help understand the carcinogenic differences in GC and have led to the identification of an Epstein-Barr virus (EBV)-related GC subtype (EBVaGC), providing new indications for tailored treatment and prognostic factors. This article provides a review of the features of EBVaGC and an update on the latest insights from EBV-related research with a particular focus on the strict interaction between EBV infection and the gastric tumor environment, including the host immune response. This information may help increase our knowledge of EBVaGC pathogenesis and the mechanisms that sustain the immune response of patients since this mechanism has been demonstrated to offer a survival advantage in a proportion of patients with GC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Re V,Brisotto G,Repetto O,De Zorzi M,Caggiari L,Zanussi S,Alessandrini L,Canzonieri V,Miolo G,Puglisi F,Belluco C,Steffan A,Cannizzaro Rdoi
10.3390/ijms21249400subject
Has Abstractpub_date
2020-12-10 00:00:00issue
24issn
1422-0067pii
ijms21249400journal_volume
21pub_type
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