Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study.

Abstract:

BACKGROUND:Uric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear. AIM:To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer. METHODS:In this prospective cohort study, 444462 participants free of cancer from the UK Biobank were included. The SUA levels were measured at baseline, and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry. The hazard ratios (HRs) and 95% confidence intervals (CIs) between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders. RESULTS:In total, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up. We found that the HR of pancreatic cancer in the highest SUA group was 1.77 (95%CI: 1.29-2.42) compared with that in the lowest group. After stratifying by gender, we further found that SUA was associated with an increased risk of pancreatic cancer only among the females (highest quartile vs lowest quartile HR 2.04, 95%CI: 1.35-3.08). Among the males, the SUA levels were positively associated with the gallbladder cancer risk (highest quartile vs lowest quartile HR 3.09, 95%CI: 1.28-7.46), but a U-shaped association with the liver cancer risk was observed (P-nonlinear = 0.03). CONCLUSION:SUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer. High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males. A U-shaped association with the liver cancer risk was identified.

journal_name

World J Gastroenterol

authors

Huang CF,Huang JJ,Mi NN,Lin YY,He QS,Lu YW,Yue P,Bai B,Zhang JD,Zhang C,Cai T,Fu WK,Gao L,Li X,Yuan JQ,Meng WB

doi

10.3748/wjg.v26.i44.7061

subject

Has Abstract

pub_date

2020-11-28 00:00:00

pages

7061-7075

issue

44

eissn

1007-9327

issn

2219-2840

journal_volume

26

pub_type

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