Abstract:
:The TDP1 (tyrosyl-DNA phosphodiesterase 1) enzyme removes the non-specific covalent intermediates between topoisomerase I and DNA, thus playing a crucial role in preventing DNA damage. While mammals possess only one TDP1 gene, in plants two genes (TDP1α and TDP1β) are present constituting a small gene subfamily. These display a different domain structure and appear to perform non-overlapping functions in the maintenance of genome integrity. Namely, the HIRAN domain identified in TDP1β is involved in the interaction with DNA during the recognition of stalled replication forks. The availability of transcriptomic databases in a growing variety of experimental systems provides new opportunities to fill the current gaps of knowledge concerning the evolutionary origin and the specialized roles of TDP1 genes in plants. Whereas a phylogenetic approach has been used to track the evolution of plant TDP1 protein, transcriptomic data from a selection of representative lycophyte, eudicots, and monocots have been implemented to explore the transcriptomic dynamics in different tissues and a variety of biotic and abiotic stress conditions. While the phylogenetic analysis indicates that TDP1α is of non-plant origin and TDP1β is plant-specific originating in ancient vascular plants, the gene expression data mining comparative analysis pinpoints for tissue- and stress-specific responses.
journal_name
Genes (Basel)journal_title
Genesauthors
Mutti G,Raveane A,Pagano A,Bertolini F,Semino O,Balestrazzi A,Macovei Adoi
10.3390/genes11121465subject
Has Abstractpub_date
2020-12-07 00:00:00issue
12issn
2073-4425pii
genes11121465journal_volume
11pub_type
杂志文章相关文献
Genes文献大全abstract::Winged bean (Psophocarpus tetragonolobus) is an herbaceous multipurpose legume grown in hot and humid countries as a pulse, vegetable (leaves and pods), or root tuber crop depending on local consumption preferences. In addition to its different nutrient-rich edible parts which could contribute to food and nutritional ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8030100
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10080568
更新日期:2019-07-26 00:00:00
abstract::Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050499
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Large-scale screening of drug sensitivity on cancer cell models can mimic in vivo cellular behavior providing wider scope for biological research on cancer. Since the therapeutic effect of a single drug or drug combination depends on the individual patient's genome characteristics and cancer cells integratio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030263
更新日期:2020-02-28 00:00:00
abstract::Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100817
更新日期:2019-10-17 00:00:00
abstract::Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) with incr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040358
更新日期:2020-03-27 00:00:00
abstract::Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins' structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using two different origi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes4020198
更新日期:2013-04-17 00:00:00
abstract::Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPTG-inducible promoter and BglBrick and BglFusion compatible multiple c...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050394
更新日期:2019-05-22 00:00:00
abstract::Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2020384
更新日期:2011-05-31 00:00:00
abstract::In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2030562
更新日期:2011-08-02 00:00:00
abstract::Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7050020
更新日期:2016-05-13 00:00:00
abstract::Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10121009
更新日期:2019-12-04 00:00:00
abstract::The autophagy-lysosome pathway, which involves many crucial genes and proteins, plays crucial roles in the maintenance of intracellular homeostasis by the degradation of damaged components. At present, some of these genes and proteins have been identified but their specific functions are largely unknown. This study wa...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100751
更新日期:2019-09-25 00:00:00
abstract:BACKGROUND:Anthocyanin pigmentation characterizes a number of tissues of Citrus and its relatives. The gain and loss of pigmentation is intriguing and is inherited variously among species. METHODS:Citrus germplasm was used to investigate the anthocyanin pigmentation of tissues never before considered, including stamen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070807
更新日期:2020-07-16 00:00:00
abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030469
更新日期:2015-06-30 00:00:00
abstract::Altered melanosome transport in melanocytes, resulting from variants in the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution in many species. In dogs, the MLPH gene corresponds to the D locus and two variants, c.-22G > A (d1) and c.705G > C (d2), leading to the dilution of coat colo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060639
更新日期:2020-06-10 00:00:00
abstract::The reconstruction of ancient metagenomes from archaeological material, and their implication in human health and evolution, is one of the most recent advances in paleomicrobiological studies. However, as for all ancient DNA (aDNA) studies, environmental and laboratory contamination need to be specifically addressed. ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090436
更新日期:2018-08-31 00:00:00
abstract::Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpne...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100818
更新日期:2019-10-17 00:00:00
abstract::Deinococcus species display a high degree of resistance to radiation and desiccation due to their ability to protect critical proteome from oxidatively generated damage; however, the underlying mechanisms are not understood. Comparative analysis of DNA repair proteins reported here has identified 22 conserved signatur...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9030149
更新日期:2018-03-08 00:00:00
abstract::Salinity is one of the major environment factors that limits the growth of plants and the productivity of crops worldwide. It has been shown that Na+ transporters play a central role in salt tolerance and development of plants. The objective of this study was to identify Na+/H+ antiporter (NHX) genes and investigate t...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050401
更新日期:2019-05-27 00:00:00
abstract::The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080411
更新日期:2018-08-14 00:00:00
abstract::Almost all eukaryotes have transposable elements (TEs) against which they have developed defense mechanisms. In the Drosophila germline, the main transposable element (TE) regulation pathway is mediated by specific Piwi-interacting small RNAs (piRNAs). Nonetheless, for unknown reasons, TEs sometimes escape cellular co...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020215
更新日期:2020-02-19 00:00:00
abstract::Breast cancer is one of the most common malignancies in women. Patient-derived tumor xenograft (PDX) model is a cutting-edge approach for drug research on breast cancer. However, PDX still exhibits differences from original human tumors, thereby challenging the molecular understanding of tumorigenesis. In particular, ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9030155
更新日期:2018-03-12 00:00:00
abstract::Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also c...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080377
更新日期:2018-07-27 00:00:00
abstract::Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade of molecular events underlying testis cord de...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10120974
更新日期:2019-11-26 00:00:00
abstract::Diploid Alnus glutinosa s. str. and autotetraploid A. rohlenae form a narrow hybrid zone in a study area in southern Serbia, which results in triploid hybrid formation. The vast majority of previous studies have been focused on studies of maternal plants, but the offspring resulting from their crossing have not been m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070770
更新日期:2020-07-09 00:00:00
abstract::Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060299
更新日期:2018-06-13 00:00:00
abstract::There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060664
更新日期:2020-06-18 00:00:00
abstract::RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090638
更新日期:2019-08-23 00:00:00