Abstract：
OBJECTIVE:To determine whether female body mass index (BMI) is associated with an increased risk of miscarriage after euploid embryo transfer. DESIGN:A retrospective, observational, multicenter cohort study. SETTING:University-affiliated in vitro fertilization center. PATIENT(S):In this study, 3,480 cycles of in vitro fertilization with preimplantation genetic testing for aneuploidy (PGT-A) in the blastocyst stage and euploid embryo transfer were divided into four groups according to patient BMI. INTERVENTION(S):In vitro fertilization with PGT-A. MAIN OUTCOME MEASURE(S):The primary outcome was the miscarriage rate, which included both biochemical and clinical miscarriages. Secondary outcomes were implantation, pregnancy, clinical pregnancy, and live birth rates. RESULT(S):Cycles were divided into four groups according to BMI (kg/m2): underweight (<18.5; n = 155), normal weight (18.5-24.9; n = 2,549), overweight (25-29.9; n = 591), and obese (≥30; n = 185). The number of PGT-A cycles per patient was similar in the four groups. Fertilization rate, day of embryo biopsy, technique of chromosomal analysis, number of euploid embryos, number of transferred embryos, and method of endometrial preparation for embryo transfer were similar in the four BMI groups. Miscarriage rates were significantly higher in women with obesity compared to women with normal weight, mainly due to a significant increase in the clinical miscarriage rates. Live birth rates also were lower in women with obesity. Obesity in women and day 6 trophectoderm biopsy were found to influence the reduced live birth rate. CONCLUSION(S):Women with obesity experience a higher rate of miscarriage after euploid embryo transfer than women with a normal weight, suggesting that other mechanisms than aneuploidy are responsible for this outcome.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Cozzolino M,García-Velasco JA,Meseguer M,Pellicer A,Bellver Jdoi
10.1016/j.fertnstert.2020.09.139subject
Has Abstractpub_date
2020-11-30 00:00:00eissn
0015-0282issn
1556-5653pii
S0015-0282(20)32373-6pub_type
杂志文章abstract：:Hysteroscopic visualization of the endometrium after 6 months of antitubercular therapy showed an improvement in the mucosal morphology. A closer visualization at increased magnification was helpful in demonstrating the remnants of a healing tubercular pathology after antitubercular therapy. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1346
更新日期：2008-03-01 00:00:00
abstract：:The effect of Korean ginseng (ginseng) on spermatogenesis and cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, reverse transcription polymerase chain reaction, and Western blot analysis. The ginseng-treated rats exhibited significantly increased sperm count and motility with e...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.014
更新日期：2007-10-01 00:00:00
abstract：:Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.03.042
更新日期：2009-04-01 00:00:00
abstract：:Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoat...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54194-6
更新日期：1991-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between female cystic fibrosis (CF) carrier status and in vitro fertilization (IVF) response and outcomes. The presence of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in male carriers has been associated with infertility, yet possible adverse effects o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.07.1234
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To propose the sperm recovering efficiency (SRE) model, an equation that can be used to objectively quantify the technical skill of individual operators processing semen specimens in an andrology laboratory. Additionally, this equation can be used to compare different semen processing methods and protocols. T...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)00253-x
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:To manipulate the luteal endometrial progression by the use of antiprogestins. DESIGN:Prospective controlled clinical trial. SETTING:The IVF program of the University of Southern California School of Medicine, Los Angeles, California. PATIENT(S):Thirteen oocyte donors and 20 oocyte recipients. INTERVENTIO...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/S0015-0282(97)81918-8
更新日期：1997-02-01 00:00:00
abstract：:Moderate ovarian hyperstimulation syndrome occurred after LA was administered to control menorrhagia in an anephric woman who required hemodialysis. We postulate that women who require dialysis may be at special risk for the development of this syndrome. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54142-9
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:To assess in utero exposures and the odds of an endometriosis diagnosis. DESIGN:Matched cohort design. SETTING:Fourteen participating clinical centers in geographically defined areas in Utah and California. PATIENT(S):Operative cohort comprised 473 women undergoing laparoscopy/laparotomy, and an age- and r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.11.013
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To characterize pubertal development of the first generation of young adults born as a result of in vitro fertilization (IVF). Demographic, clinical, and body size characteristics were examined regarding developmental milestones. DESIGN:Cross-sectional. SETTING:Academic center. PATIENT(S):Young adults (18-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.04.057
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.07.1537
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:To determine intrafollicular hormone levels and characterize the mRNA expression of the insulin-like growth factor (IGF) receptors, IGF binding proteins (IGFBP), and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells before and after an ovulatory hCG stimulus. DESIGN:Experimental animal study....
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.12.096
更新日期：2010-03-15 00:00:00
abstract：:Surrogacy raises a number of concerns about the psychological adjustment of the surrogate, the parents, and the child. Despite surrogacy becoming more common, research into the postdelivery psychological adjustment of the individuals involved has lagged far behind. This review examines research on the psychological ad...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2020.03.010
更新日期：2020-05-01 00:00:00
abstract：:Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60136-x
更新日期：1988-09-01 00:00:00
abstract：:A study was undertaken to examine the influence of pH on the migration of X and Y sperm as observed in freshly ejaculated semen samples from human donors. These sperm were allowed to migrate into capillary tubes containing media of varying pH. Y-carrying sperm were i dentified using flourescent staining with quinacr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)38224-3
更新日期：1971-05-01 00:00:00
abstract：OBJECTIVE:To assess the role of embryo secretome in modifying the molecular profile of glycodelin A (GdA) in endometrial organoids (ORG) mimicking the implantation window. To verify whether the use of embryo-conditioned culture medium at the time of the embryo transfer may increase in vitro fertilization outcome. DESI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.10.058
更新日期：2021-01-23 00:00:00
abstract：OBJECTIVE:To determine the distribution of catalase in eutopic and ectopic endometria in patients with endometriosis or adenomyosis. DESIGN:Retrospective randomized study. SETTING:Department of obstetrics and gynecology in a university hospital. PATIENT(S):Thirty-three patients with endometriosis, 36 with adenomyosi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03344-7
更新日期：2002-10-01 00:00:00
abstract：:The antiprogesterone compound RU 486 (17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-[ 1-propynyl]estra-4,9-dien-3-one; Roussel-Uclaf, Paris, France) was used to induce menstruation in a randomized controlled trial. Castrated adult female cynomolgus monkeys (n = 17) received sequential subcutaneous Silastic ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47246-8
更新日期：1983-08-01 00:00:00
abstract：OBJECTIVE:To understand the correlation between normalcy of the sperm, fertilization, and early embryo development, and to establish a detailed classification scoring scale for the individual spermatozoon with the highest predictive fertilizing potential in real time during intracytoplasmic sperm injection (ICSI). DES...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.08.088
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To determine the variability in the recognition of normal sperm and various sperm defects using the strict criteria recommended by the World Health Organization (5th edition, 2010). DESIGN:Sperm morphologic assessment by three experienced evaluators. SETTING:Image processing laboratory and reproduction rese...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.12.047
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To study the psychological effects of multifetal pregnancy reduction. DESIGN AND SETTING:Hour-long semistructured telephone interviews with both multifetal pregnancy reduction patients and control subjects. PATIENTS:Forty-two multifetal pregnancy reduction patients were contacted within 1 year of undergoing...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Ovarian hyperstimulation syndrome (OHSS) is one of the most serious, and potentially lethal, complications of controlled ovarian stimulation (COS). Induction of final oocyte maturation with a bolus of gonadotropin-releasing hormone (GnRH) agonist (GnRHa), instead of the criterion standard hCG, in patients undergoing o...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2015.02.004
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and side effects of vaginal misoprostol with dinoprostone for cervical priming before operative hysteroscopy and to assess the cervicouterine complications related to cervical dilatation and hysteroscopic surgery. DESIGN:A prospective randomized study. SETTING:Tertiary university hos...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2006.03.039
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To present and determine the impact of the Mindfulness-Based Program for Infertility (MBPI). DESIGN:Controlled clinical trial. SETTING:University research unit. PATIENT(S):Fifty-five infertile women completed the MBPI, and 37 infertile women were assigned to a control group. INTERVENTION(S):The MBPI inclu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.05.036
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To assess sexual function in women with spontaneous 46,XX primary ovarian insufficiency after at least 3 months of a standardized hormone replacement regimen. DESIGN:Cross-sectional cohort, controlled. SETTING:National Institutes of Health Clinical Research Center. PATIENT(S):Women with primary ovarian ins...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2007.08.040
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:To assess how genetic evaluations of sperm donor applicants are performed in the United States. DESIGN:A questionnaire was designed to assess: 1) the professionals involved in the family history evaluation and genetic screening; 2) the genetic testing, counseling, and informed consent processes; and 3) how t...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2013.01.093
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of estrogen (E) alone or with cyclic, continuous, or interrupted P regimens on bone density in an aged rat model. DESIGN:Randomized controlled trial. ANIMALS:Twenty 12-month-old female Sprague-Dawley rats were sham operated (intact control) and 100 were ovariectomized (OVX). INTE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of thawing temperature on sperm function after cryopreservation. The technical aspects of sperm cryopreservation have significantly improved over the last few decades. However, a standard protocol designed to optimize sperm motility recovery after thawing has not yet been establishe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.10.021
更新日期：2010-02-01 00:00:00
abstract：:Catecholamine concentrations were determined in left spermatic vein blood of 18 patients with varicocele. These values were compared with concentrations of catecholamines in the right femoral vein. Of 18 patients studied, 6 had moderate to marked elevations of spermatic vein catecholamine concentrations. Norepinephrin...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41541-4
更新日期：1975-12-01 00:00:00
abstract：OBJECTIVE:To explore the effect of letrozole as an ovulation inducing agent on oocyte and embryo quality in mice model. DESIGN:Prospective study. SETTING:Institute of Reproductive Medicine, Kolkata, India. ANIMAL(S):Sixty-nine sexually mature female Swiss Albino mice 6-7 weeks old. INTERVENTION(S):Metaphase II (MII...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.04.045
更新日期：2010-03-15 00:00:00
