Baboon models of acute arterial thrombosis.

abstract：:Microvascular endothelial damage underlies the pathological changes in haemorrhagic colitis and the haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). Shiga toxins (Stxs) are presently the best characterised EHEC virulence factors that can cause the microvascular endothelium injury...

journal_title：Thrombosis and haemostasis

authors： Bielaszewska M,Karch H

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND: Carotid atherosclerosis is an important cause of stroke. Intra-plaque haemorrhage (IPH) on magnetic resonance imaging (MRI) increases stroke risk. Development of IPH is only partly understood. Thrombin is an essential enzyme in haemostasis. Experimental animal studies have shown conflicting results on the r...

journal_title：Thrombosis and haemostasis

authors： Crombag GAJC,Spronk HM,Nelemans P,Schreuder FHBM,Truijman MTB,van Dijk AC,de Rotte AAJ,Liem MI,Daemen MJAP,van der Steen AFW,Mess WH,Nederkoorn PJ,Hendrikse J,van der Lugt A,Wildberger JE,Ten Cate H,van Oostenbrugge RJ,

更新日期：2018-08-01 00:00:00

abstract：:Glucose intolerance, hyperinsulinaemia, dyslipoproteinaemia and multiple disturbances of haemostatic function are characteristics of young men with premature coronary artery disease. The relations between glucose, insulin and insulin propeptides, in the fasting state, and after an oral glucose load, and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Båvenholm P,Proudler A,Silveira A,Crook D,Blombäck M,de Faire U,Hamsten A

更新日期：1995-04-01 00:00:00

abstract：:Collagen (10-90 micrograms/ml) and ionomycin (1 microM; a calcium ionophore) each evoked rises in intracellular free calcium, protein kinase C activity and arachidonic acid release in human platelets, and as previously demonstrated for collagen, ionomycin (1 microM) stimulated protein tyrosine phosphorylation. However...

journal_title：Thrombosis and haemostasis

authors： Hargreaves PG,Jenner S,Merritt JE,Sage SO,Farndale RW

更新日期：1996-08-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect thes...

journal_title：Thrombosis and haemostasis

authors： Richter B,Niessner A,Penka M,Grdić M,Steiner S,Strasser B,Ziegler S,Zorn G,Maurer G,Simeon-Rudolf V,Wojta J,Huber K

更新日期：2005-12-01 00:00:00

abstract：:Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

journal_title：Thrombosis and haemostasis

authors： Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

更新日期：1986-02-28 00:00:00

abstract：:The effect of chronic administration of ethanol to rats in a controlled regimen upon the activities of the coagulation factors II, VII, VIII, IX and X has been studied. No significant differences were found for factor II, IX and X between the ethanol-treated rats and the control group given an isocaloric diet with car...

journal_title：Thrombosis and haemostasis

authors： Morland J,Holm T,Prydz H

更新日期：1976-12-31 00:00:00

abstract：:This study was performed to follow up on the observation that gelatinase A (MMP-2) deficiency impairs adipose tissue development in mice. The aim was to evaluate the role of its functional homologue gelatinase B (MMP-9) in adipose tissue growth. MMP-9 antigen levels were determined in lean and in obese women before an...

journal_title：Thrombosis and haemostasis

authors： Van Hul M,Piccard H,Lijnen HR

更新日期：2010-07-01 00:00:00

abstract：:Although intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) play a relevant role in atherosclerosis, little is known about the prognostic impact of their soluble forms (s) in patients with peripheral arterial disease (PAD). The aim of this prospective study was to verify whether ...

journal_title：Thrombosis and haemostasis

authors： Silvestro A,Brevetti G,Schiano V,Scopacasa F,Chiariello M

更新日期：2005-03-01 00:00:00

abstract：:Elderly patients have previously been shown to have an increased plasma concentration of tissue plasminogen activator (t-PA) antigen (t-PA Ag). Since the concentration of t-PA Ag depends on both free t-PA and t-PA complexed with inhibitors, mainly plasminogen activator inhibitor (PA inhibitor), we have investigated th...

journal_title：Thrombosis and haemostasis

authors： Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

更新日期：1986-06-30 00:00:00

abstract：:Data on anti-platelet therapy (APT) for prevention of atherothrombotic events in thrombocytopaenic cancer patients is lacking. We aimed to identify patient and physician characteristics associated with APT management in thrombocytopaenic patients with haematological malignancy. A clinical vignette-based experiment was...

journal_title：Thrombosis and haemostasis

authors： Leader A,Ten Cate V,Ten Cate-Hoek AJ,Spectre G,Beckers EAM,Raanani P,Giaccherini C,Pereg D,Schouten HC,Falanga A,Ten Cate H

更新日期：2019-01-01 00:00:00

abstract：:The strong effect of protein adsorption on blood and tissue compatibility is well known. Little is presently known about the mechanisms which control the composition of the adsorbed protein layer which forms upon exposure of surfaces to mixtures of proteins. Reexamination of the ability of hemoglobin to inhibit the ad...

journal_title：Thrombosis and haemostasis

authors： Horbett TA

更新日期：1984-04-30 00:00:00

abstract：:The prothrombin time (PT) test is used to monitor oral anticoagulant therapy. Contact activation of patient blood samples in vitro may shorten the PT and thus lead to underestimation of the degree of anticoagulation. Commercial evacuated tubes for blood collection have been reported to induce shortening of the PT. The...

journal_title：Thrombosis and haemostasis

authors： van den Besselaar AM,van Halem-Visser LP,Loeliger EA

更新日期：1983-10-31 00:00:00

abstract：:The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003...

journal_title：Thrombosis and haemostasis

authors： Kenet G,Waldman D,Lubetsky A,Kornbrut N,Khalil A,Koren A,Wolach B,Fattal A,Kapelushnik J,Tamary H,Yacobovitch J,Raveh E,Revel-Vilk S,Toren A,Brenner B

更新日期：2004-10-01 00:00:00

abstract：:In patients with deep vein thrombosis (DVT), the factors which predispose to concomitant symptomatic pulmonary embolism (PE) have remained uncertain. From a prospective cohort of 5,451 consecutive patients with ultrasound-confirmed DVT, we analyzed 4,211 patients with a known status for presence (n=639) or absence (n=...

journal_title：Thrombosis and haemostasis

authors： Kucher N,Tapson VF,Goldhaber SZ,DVT FREE Steering Committee.

更新日期：2005-03-01 00:00:00

abstract：:Prasugrel, through its active metabolite, reduces atherothrombosis and its clinical manifestations by inhibiting platelet activation and aggregation. Platelets also contribute to inflammation through interaction with different classes of leukocytes. We investigated whether the inhibitory effect of prasugrel on platele...

journal_title：Thrombosis and haemostasis

authors： Totani L,Dell'Elba G,Martelli N,Di Santo A,Piccoli A,Amore C,Evangelista V

更新日期：2012-06-01 00:00:00

abstract：:We report genetic abnormalities of protein C gene in a male infant who developed neonatal purpura fulminans. DNA-sequence analysis of all exons in protein C gene in this family revealed two mutations. The first abnormality, derived from the mother, was a deletion of one of four consecutive G at nucleotide number 10758...

journal_title：Thrombosis and haemostasis

authors： Ido M,Ohiwa M,Hayashi T,Nishioka J,Hatada T,Watanabe Y,Wada H,Shirakawa S,Suzuki K

更新日期：1993-10-18 00:00:00

abstract：:The origin and evolution of venom toxins is a mystery that has evoked much interest. We have recently shown that pseutarin C, a prothrombin activator from Pseudonaja textilis venom, is structurally and functionally similar to mammalian coagulation factor Xa-factor Va complex. Its catalytic subunit is homologous to fac...

journal_title：Thrombosis and haemostasis

authors： Minh Le TN,Reza MA,Swarup S,Kini RM

更新日期：2005-03-01 00:00:00

abstract：:A multicenter study of various types of von Willebrand's disease (vWD) was conducted in order to compare the different electrophoretic techniques used to evaluate von Willebrand factor multimers in plasma. Seven laboratories participated in the blind study of eight plasma samples from two healthy subjects and six vWD ...

journal_title：Thrombosis and haemostasis

authors： Mannucci PM,Abildgaard CF,Gralnick HR,Hill FG,Hoyer LW,Lombardi R,Nilsson IM,Tuddenham E,Meyer D

更新日期：1985-12-17 00:00:00

abstract：:In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin cytoskeletal structures - stress fibers, lamellipodia and filopodia - to complex integrators of cytoskeletal structures that can exert multiple functions dependi...

journal_title：Thrombosis and haemostasis

authors： Beckers CM,van Hinsbergh VW,van Nieuw Amerongen GP

更新日期：2010-01-01 00:00:00

abstract：:Type I von Willebrand disease (vWD) Vicenza is a rare variant with autosomal dominant transmission, characterized by the presence of supranormal von Willebrand factor (vWF) multimers in plasma, similar to those normally found in endothelial cells and megakaryocytes. The patients have very low levels of plasma vWF cont...

journal_title：Thrombosis and haemostasis

authors： Randi AM,Sacchi E,Castaman GC,Rodeghiero F,Mannucci PM

更新日期：1993-02-01 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:The influence of the sympathetic nervous system on platelet functions in vivo is still controversial. The aims of our study were to compare the response to various sympathetic stimuli in normal subjects and in patients with essential hypertension (HT) or peripheral vascular disease (PVD) and to evaluate any correlatio...

journal_title：Thrombosis and haemostasis

authors： Catalano M,Russo U,Belletti S,Colombo F,Belloni A,del Rosso G,Lombardi F,Libretti A

更新日期：1990-06-28 00:00:00

abstract：:Inhibition of adenylate cyclase in intact platelets by addition of compounds such as 2', 5' - dideoxyadenosine prevented the inhibition of platelet aggregation by PGE1 but did not affect the responses of platelets to aggregating agents in the absence of PGE1. This confirms that cyclic AMP mediates the effects of PGE1 ...

journal_title：Thrombosis and haemostasis

authors： Haslam RJ,Davidson MM,Fox JE,Lynham JA

更新日期：1978-10-31 00:00:00

abstract：:In health, haemostasis and angiogenesis are tightly regulated processes, but may become deregulated in cancer. Recent evidence suggests that platelet activation may link these processes as platelets can release angiogenic factors such as vascular endothelial growth factor (VEGF). Furthermore, inflammation has also bee...

journal_title：Thrombosis and haemostasis

authors： Caine GJ,Lip GY,Stonelake PS,Ryan P,Blann AD

更新日期：2004-07-01 00:00:00

abstract：:A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 2...

journal_title：Thrombosis and haemostasis

authors： Harrison CN,Donohoe S,Carr P,Dave M,Mackie I,Machin SJ

更新日期：2002-05-01 00:00:00

abstract：:The binding properties of purified bovine fibrinogen to bovine aortic endothelial cells have been examined in a tissue culture system. Endothelial cells bound 125I-fibrinogen in a calcium dependent fashion. Removal of calcium by EDTA instantaneously detached most of the cell-associated fibrinogen. Binding of fibrinoge...

journal_title：Thrombosis and haemostasis

authors： Delvos U,Preissner KT,Müller-Berghaus G

更新日期：1985-02-18 00:00:00

abstract：:A nutritionally induced obesity model was used to investigate the modulation of fibrinolytic and gelatinolytic activity during the development of adipose tissue. Five week old male mice were fed a standard fat diet (SFD, 13% kcal as fat) or a high fat diet (HFD, 42% kcal as fat) for up to 15 weeks. The HFD resulted in...

journal_title：Thrombosis and haemostasis

authors： Lijnen HR,Maquoi E,Demeulemeester D,Van Hoef B,Collen D

更新日期：2002-08-01 00:00:00

abstract：:The contribution of the various components of the contact system in the generation of factor XIIa (FXIIa) and of kallikrein (KRN) on an electronegative surface and the release of the generated enzymes to the bulk phase was examined in mixtures of normal human plasma and plasmas congenitally deficient in these componen...

journal_title：Thrombosis and haemostasis

authors： Mitropoulos KA

更新日期：1999-09-01 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00