Neurocognitive effects of six ketamine infusions and the association with antidepressant effects in treatment-resistant bipolar depression: a preliminary study.

Abstract:

Objective:The N-methyl-D-aspartate subtype glutamate receptor antagonist ketamine has rapid antidepressant and antisuicidal effects in treating treatment-resistant bipolar depression (TRBD). The neurocognitive effects of repeated ketamine infusions in TRBD are not known. Methods:Six intravenous infusions of ketamine (0.5 mg/kg over 40 min) were administered on a Monday-Wednesday-Friday schedule during a 12-day period on 16 patients with TRBD followed by a 2-week observational period. The assessment of neurocognitive function was conducted using the MATRICS Consensus Cognitive Battery at baseline, 13 and 26 days. Tasks were designed to test speed of processing, working memory, visual learning and verbal learning. Results:A significant improvement was found only in scores of speed of processing (F = 9.9, p = 0.001) after a 2-week observational period, which was accounted for by the improvement of depression symptoms. There were no significant changes over time in terms of working memory, visual learning and verbal learning. Pearson correlation analysis showed that the improvement of depression symptoms through six ketamine infusions was greater among TRBD patients with lower working memory at baseline (r = 0.54, p = 0.03). In multiple regression analysis, the significant correlation was still maintained (beta = 0.67, t = 2.2, p = 0.04). Conclusion:This preliminary study indicated that six ketamine infusions were not harmful but were slightly beneficial for speed of processing in TRBD. However, this change was mainly accounted for the improvement of depression symptoms over time. Lower baseline working memory appears to be associated with greater antidepressant response after completion of six ketamine infusions in patients with TRBD.

journal_name

PeerJ

journal_title

PeerJ

authors

Zheng W,Zhou YL,Wang CY,Lan XF,Zhang B,Yang MZ,Nie S,Ning YP

doi

10.7717/peerj.10208

subject

Has Abstract

pub_date

2020-11-03 00:00:00

pages

e10208

issn

2167-8359

pii

10208

journal_volume

8

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Impacts of diarrhea on the immune system, intestinal environment, and expression of PGRPs in New Zealand rabbits.

    abstract::Diarrhea is a syndrome of digestive disorders in young rabbits and may lead to secondary infections resulting in reduced immunity and higher mortality in baby rabbits, with serious impacts on rabbit farming. In this study, we investigated the effects of diarrhea on the health of baby rabbits in terms of intestinal muc...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4100

    authors: Chen Y,Zhao B,Wu Y,Hu S,Mu L,Zhu C,Pan Y,Wu X

    更新日期:2017-11-27 00:00:00

  • Drug delivery systems for ovarian cancer treatment: a systematic review and meta-analysis of animal studies.

    abstract::Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects. To overcome these limitations, drug delivery systems (DDS) have been developed to encapsulate chemotherapeutics for delivery to tumor cells. However, no sys...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1489

    authors: Raavé R,de Vries RB,Massuger LF,van Kuppevelt TH,Daamen WF

    更新日期:2015-12-10 00:00:00

  • Comparison of physiological responses of Arabian striped hyaena (Hyaena hyaena sultana) to effective immobilisations with ketamine-medetomidine and ketamine-xylazine in (semi-) captive conditions.

    abstract::Chemical immobilisation is an integral component for the conservation of wild animals and can be stressful if proper protocols are not administered. References on the immobilisation of Arabian striped hyaena (Hyaena hyaena sultana) are scarce. The current study was designed to evaluate the physiological and clinical r...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7326

    authors: Mehmood A,Abid S,Hejcmanová P,Asadi MA,Kabeer B,Jilani MJ,Bilal S,Ashraf MW

    更新日期:2019-07-26 00:00:00

  • Importance of considering interoceptive abilities in alexithymia assessment.

    abstract:Background:Recent studies have shown that people with high alexithymia scores have decreased interoceptive abilities, which can be associated with psychological and physical disorders. Early assessments of the alexithymia trait included the evaluation of these abilities through the dimension measuring the difficulty in...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7615

    authors: Fournier A,Luminet O,Dambrun M,Dutheil F,Pellissier S,Mondillon L

    更新日期:2019-11-20 00:00:00

  • Effect of acute eye fatigue on cognition for young females: a pilot study.

    abstract::The number of people suffering from eye fatigue induced by visual display terminal (VDT) viewing is expected to increase in the modern world. Eye dysfunction is suggested to induce a decrease in cognitive function, at least in the long term. Furthermore, considering other previous findings, it may be reasonable to thi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7978

    authors: Akagi R,Tonotsuka M,Horie R,Hirata K,Ando S

    更新日期:2019-10-29 00:00:00

  • A comprehensive review of circRNA: from purification and identification to disease marker potential.

    abstract::Circular RNA (circRNA) is an endogenous noncoding RNA with a covalently closed cyclic structure. Based on their components, circRNAs are divided into exonic circRNAs, intronic circRNAs, and exon-intron circRNAs. CircRNAs have well-conserved sequences and often have high stability due to their resistance to exonuclease...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5503

    authors: Xu S,Zhou L,Ponnusamy M,Zhang L,Dong Y,Zhang Y,Wang Q,Liu J,Wang K

    更新日期:2018-08-24 00:00:00

  • Comparing the catch composition, profitability and discard survival from different trammel net designs targeting common spiny lobster (Palinurus elephas) in a Mediterranean fishery.

    abstract::In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catche...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4707

    authors: Catanese G,Hinz H,Gil MDM,Palmer M,Breen M,Mira A,Pastor E,Grau A,Campos-Candela A,Koleva E,Grau AM,Morales-Nin B

    更新日期:2018-05-17 00:00:00

  • A new tiny toad species of Amazophrynella (Anura: Bufonidae) from east of the Guiana Shield in Amazonia, Brazil.

    abstract::The combination of different approaches has successfully delimited new species within many Neotropical species complexes traditionally classified as a single nominal organism. Recent studies have shown that the Amazonian endemic genus Amazophrynella, currently composed of 12 small-sized species, could harbor several a...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9887

    authors: Mângia S,Koroiva R,Santana DJ

    更新日期:2020-09-18 00:00:00

  • Implementation of the Xpert MTB/RIF assay for tuberculosis in Mongolia: a qualitative exploration of barriers and enablers.

    abstract:OBJECTIVE:The aim of our study was to identify barriers and enablers to implementation of the Xpert MTB/RIF test within Mongolia's National Tuberculosis Program. METHODS:Twenty-foursemi-structured interviews were conducted between June and September 2015 with laboratory staff and tuberculosis physicians in Mongolia's ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3567

    authors: Rendell NL,Bekhbat S,Ganbaatar G,Dorjravdan M,Pai M,Dobler CC

    更新日期:2017-07-14 00:00:00

  • VSEARCH: a versatile open source tool for metagenomics.

    abstract:BACKGROUND:VSEARCH is an open source and free of charge multithreaded 64-bit tool for processing and preparing metagenomics, genomics and population genomics nucleotide sequence data. It is designed as an alternative to the widely used USEARCH tool (Edgar, 2010) for which the source code is not publicly available, algo...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2584

    authors: Rognes T,Flouri T,Nichols B,Quince C,Mahé F

    更新日期:2016-10-18 00:00:00

  • Long-term administration of vitamin B12 and adenosine triphosphate for idiopathic sudden sensorineural hearing loss: a retrospective study.

    abstract:Background:In idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood. Objective:To investigate the therapeutic effect of long-term 16 (≥weeks) administrat...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10406

    authors: Kurioka T,Sano H,Furuki S,Yamashita T

    更新日期:2020-12-16 00:00:00

  • MetaBAT, an efficient tool for accurately reconstructing single genomes from complex microbial communities.

    abstract::Grouping large genomic fragments assembled from shotgun metagenomic sequences to deconvolute complex microbial communities, or metagenome binning, enables the study of individual organisms and their interactions. Because of the complex nature of these communities, existing metagenome binning methods often miss a large...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1165

    authors: Kang DD,Froula J,Egan R,Wang Z

    更新日期:2015-08-27 00:00:00

  • Evolution of the scholarly mega-journal, 2006-2017.

    abstract::Mega-journals are a new kind of scholarly journal made possible by electronic publishing. They are open access (OA) and funded by charges, which authors pay for the publishing services. What distinguishes mega-journals from other OA journals is, in particular, a peer review focusing only on scientific trustworthiness....

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4357

    authors: Björk BC

    更新日期:2018-02-09 00:00:00

  • A phylogenetic taxonomy of the Cyrtodactylus peguensis group (Reptilia: Squamata: Gekkonidae) with descriptions of two new species from Myanmar.

    abstract::A phylogenetic taxonomy of species in the Cyrtodactylus peguensis group from the Ayeyarwady Basin of Myanmar is constructed based on color pattern, morphology, and molecular systematic analyses using the mitochondrial gene NADH dehydrogenase subunit 2. Newly collected samples from the type locality of C. peguensis and...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5575

    authors: Grismer LL,Wood PL Jr,Quah ESH,Murdoch ML,Grismer MS,Herr MW,Espinoza RE,Brown RM,Lin A

    更新日期:2018-09-19 00:00:00

  • Effects of stream grazers with different functional traits on the spatial heterogeneity of periphyton mats.

    abstract:Background:Grazing activity on periphytic mats determines mat structure and spatial heterogeneity. Spatial complexity in stream periphyton is highly divergent and may depend on the functional traits of the different primary consumers species (i.e., grazers) such as mouthpart morphology, feeding behavior, and feeding ac...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6747

    authors: Katano I,Doi H

    更新日期:2019-06-05 00:00:00

  • Forelimb muscle and joint actions in Archosauria: insights from Crocodylus johnstoni (Pseudosuchia) and Mussaurus patagonicus (Sauropodomorpha).

    abstract::Many of the major locomotor transitions during the evolution of Archosauria, the lineage including crocodiles and birds as well as extinct Dinosauria, were shifts from quadrupedalism to bipedalism (and vice versa). Those occurred within a continuum between more sprawling and erect modes of locomotion and involved dras...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3976

    authors: Otero A,Allen V,Pol D,Hutchinson JR

    更新日期:2017-11-24 00:00:00

  • In vitro gastrointestinal digestion study of a novel bio-tofu with special emphasis on the impact of microbial transglutaminase.

    abstract::We have developed a novel bio-tofu, made from mixed soy and cow milk (MSCM), using Lactobacillus helveticus MB2-1 and Lactobacillus plantarum B1-6 incorporated with microbial transglutaminase (MTGase) as coagulant. MTGase was added to improve the textural properties and suit for cooking. However, the effect of MTGase ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2754

    authors: Xing G,Rui X,Jiang M,Xiao Y,Guan Y,Wang D,Dong M

    更新日期:2016-12-15 00:00:00

  • Synthesis of silver nanoparticles using a Mentha spicata extract and evaluation of its anticancer and cytotoxic activity.

    abstract::In this study, silver nanoparticles (NP) were synthesized by two methods: using an aqueous extract of Mentha spicata leaves and using citrate ions as stabilizing agent, and the cytotoxicity and anticancer activity of both NP were evaluated in vitro. The particles synthesized with the aqueous extract were spherical wit...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8142

    authors: Torres-Martínez Y,Arredondo-Espinoza E,Puente C,González-Santiago O,Pineda-Aguilar N,Balderas-Rentería I,López I,Ramírez-Cabrera MA

    更新日期:2019-12-09 00:00:00

  • The role of awareness of repetition during the development of automaticity in a dot-counting task.

    abstract::This study examined whether being aware of the repetition of stimuli in a simple numerosity task could aid the development of automaticity. The numerosity task used in this study was a simple counting task. Thirty-four participants were divided into two groups. One group was instructed that the stimuli would repeat ma...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4329

    authors: Speelman CP,Shadbolt E

    更新日期:2018-01-31 00:00:00

  • Sample entropy analysis for the estimating depth of anaesthesia through human EEG signal at different levels of unconsciousness during surgeries.

    abstract::Estimating the depth of anaesthesia (DoA) in operations has always been a challenging issue due to the underlying complexity of the brain mechanisms. Electroencephalogram (EEG) signals are undoubtedly the most widely used signals for measuring DoA. In this paper, a novel EEG-based index is proposed to evaluate DoA for...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4817

    authors: Liu Q,Ma L,Fan SZ,Abbod MF,Shieh JS

    更新日期:2018-05-23 00:00:00

  • Seasonal regulation of herbivory and nutrient effects on macroalgal recruitment and succession in a Florida coral reef.

    abstract::Herbivory and nutrient enrichment are drivers of benthic dynamics of coral reef macroalgae; however, their impact may vary seasonally. In this study we evaluated the effects of herbivore pressure, nutrient availability and potential propagule supply on seasonal recruitment and succession of macroalgal communities on a...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2643

    authors: Duran A,Collado-Vides L,Burkepile DE

    更新日期:2016-11-02 00:00:00

  • Population connectivity and larval dispersal of the exploited mangrove crab Ucides cordatus along the Brazilian coast.

    abstract:Background:The mangrove crab Ucides cordatus is considered a key species for the ecological balance of mangrove forests and a major source of employment and income for traditional crab collectors in Brazil. Several studies evidenced weak genetic variation among populations due to an efficient larval transport. However,...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4702

    authors: Britto FB,Schmidt AJ,Carvalho AMF,Vasconcelos CCMP,Farias AM,Bentzen P,Diniz FM

    更新日期:2018-04-30 00:00:00

  • Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum.

    abstract::This study aimed to investigate the effects of Clostridium butyricum as a dietary probiotic supplement in fishmeal based diet on growth, gut microbiota and immune performance of marron (Cherax cainii). Marron were randomly distributed into two different treatment groups, control and probiotic fed group. After 42 days ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7553

    authors: Foysal MJ,Nguyen TTT,Chaklader MR,Siddik MAB,Tay CY,Fotedar R,Gupta SK

    更新日期:2019-08-27 00:00:00

  • Efficacy and safety of low molecular weight heparin compared to unfractionated heparin for chronic outpatient hemodialysis in end stage renal disease: systematic review and meta-analysis.

    abstract::Background. Low molecular weight heparin (LMWH) is an effective anti-coagulant for thrombotic events. However, due to its predominant renal clearance, there are concerns that it might be associated with increased bleeding in patients with renal disease. Objectives. We systematically evaluated the efficacy and safety o...

    journal_title:PeerJ

    pub_type: 杂志文章,评审

    doi:10.7717/peerj.835

    authors: Palamaner Subash Shantha G,Kumar AA,Sethi M,Khanna RC,Pancholy SB

    更新日期:2015-03-10 00:00:00

  • Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses.

    abstract:Background:BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated. This study aims to identify the gene expression profiles and interaction networks influenced by BR...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8403

    authors: Li Y,Zhou X,Liu J,Yin Y,Yuan X,Yang R,Wang Q,Ji J,He Q

    更新日期:2020-01-21 00:00:00

  • Persistent mosquito fogging can be detrimental to non-target invertebrates in an urban tropical forest.

    abstract:Background:Human population growth has led to biodiversity declines in tropical cities. While habitat loss and fragmentation have been the main drivers of urban biodiversity loss, man-made interventions to reduce health risks have also emerged as an unintentional threat. For instance, insecticide fogging to control mos...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10033

    authors: Lee NSM,Clements GR,Ting ASY,Wong ZH,Yek SH

    更新日期:2020-10-01 00:00:00

  • Watch-wearing as a marker of conscientiousness.

    abstract::Several aspects of an individual's appearance have been shown to predict personality and related behaviour. While some of these cues are grounded in biology (e.g., the human face), other aspects of a person's appearance can be actively controlled (e.g., clothing). In this paper, we consider a common fashion accessory,...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1210

    authors: Ellis DA,Jenkins R

    更新日期:2015-08-27 00:00:00

  • A "modified Obel" method for the severity scoring of (endocrinopathic) equine laminitis.

    abstract:Background:Laminitis is a common equine disease characterized by foot pain, and is commonly diagnosed using a five-grade Obel system developed in 1948 using sepsis-related cases. However, endocrinopathic laminitis is now the most common form of the disease and clinical signs may be mild, or spread across two Obel grade...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7084

    authors: Meier A,de Laat M,Pollitt C,Walsh D,McGree J,Reiche DB,von Salis-Soglio M,Wells-Smith L,Mengeler U,Mesa Salas D,Droegemueller S,Sillence MN

    更新日期:2019-06-07 00:00:00

  • Classification of genomic components and prediction of genes of Begomovirus based on subsequence natural vector and support vector machine.

    abstract:Background:Begomoviruses are widely distributed and causing devastating diseases in many crops. According to the number of genomic components, a begomovirus is known as either monopartite or bipartite begomovirus. Both the monopartite and bipartite begomoviruses have the DNA-A component which encodes all essential prot...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9625

    authors: Pei S,Dong R,Bao Y,He RL,Yau SS

    更新日期:2020-08-03 00:00:00

  • The use of bat houses as day roosts in macadamia orchards, South Africa.

    abstract::The loss of roost sites is one of the major drivers of the worldwide decline in bat populations and roost site preferences, either natural or artificially provided, are not well known for African bat species specifically. In this study we focus on the preference for different artificial roost sites by insectivorous ba...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6954

    authors: Weier SM,Linden VMG,Grass I,Tscharntke T,Taylor PJ

    更新日期:2019-05-22 00:00:00