Abstract：
:Glucagon-like peptide-1 receptor agonists and sodium-dependent glucose cotransporter-2 inhibitors have demonstrated clinically significant benefits on glycated hemoglobin, weight, blood pressure and cardiorenal outcomes. The emerging evidence from clinical trials and meta-analyses that assessed the combination of these 2 classes of drugs has been promising. An expert forum that included individuals with expertise in endocrine, cardiology and nephrology issues was held in May 2020 to review the literature on the metabolic and cardiorenal benefits of these 2 classes, independently and in combination, in adults with type 2 diabetes mellitus. Although hard outcome data are not available, the group concluded that the combination of glucagon-like peptide-1 receptor agonists with sodium-dependent glucose cotransporter-2 inhibitors is an emerging option for managing adults with type 2 diabetes as long as cost is not a barrier. Ongoing research may offer further insights on hard cardiorenal outcomes for this therapeutic combination as well as provide direction on the potential of this approach in obesity, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis and populations without diabetes.
journal_name
Can J Diabetesjournal_title
Canadian journal of diabetesauthors
Goldenberg RM,Ahooja V,Clemens KK,Gilbert JD,Poddar M,Verma Sdoi
10.1016/j.jcjd.2020.09.005subject
Has Abstractpub_date
2020-09-14 00:00:00eissn
1499-2671issn
2352-3840pii
S1499-2671(20)30367-1pub_type
杂志文章,评审abstract：:Low grade inflammation has been linked to risk of type 2 diabetes and atherosclerotic vascular diseases. Obesity and, in particular, abdominal obesity increase the risk of diabetes and atherosclerotic vascular diseases. One of the mechanisms could be low grade inflammation and vascular endothelial dysfunction. Permane...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.07.029
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:Physicians lack clear guidance about adaptation of clinical practice guidelines for elderly institutionalized patients with diabetes. In a large long-term care facility, a diabetes management flow sheet was trialed to determine which clinical parameters were found useful by clinicians in the management of di...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2014.12.001
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:The short version of the Activities-Specific Balance Confidence Scale (ABC-6) is advantageous in busy clinical or research settings because it can be administered in less time than the original 16-item Activities-Specific Balance Confidence Scale (ABC-16). This pilot study examined the convergent, discrimina...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.10.007
更新日期：2017-06-01 00:00:00
abstract：:Cerebral edema (CE) is a rare but potentially fatal complication of diabetic ketoacidosis (DKA) in children with type 1 diabetes. CE is frequently mentioned as being more common in young children. The primary objective of this study was to review the evidence suggesting that younger age is a risk factor for the develo...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2019.04.013
更新日期：2020-02-01 00:00:00
abstract：:Effective glycemic control reduces the risk for diabetes-related complications. However, the majority of patients with type 2 diabetes still do not achieve glycemic targets. Beyond metformin therapy, current practice guidelines for the management of type 2 diabetes recommend individualized treatment based on patient a...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2015.09.001
更新日期：2015-12-01 00:00:00
abstract：:If a disease state is highly prevalent and its consequences are severe, it may be appropriate to seek methods to identify it early to forestall its development and complications. Diabetes mellitus is a proven risk factor for the development of atherosclerosis, although its face and outcome are changing, as shown in co...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2019.08.009
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:This study describes associations between depressive symptoms and indices of obesity in a community sample of adults with prediabetes. The strengths of these associations were compared to those observed in individuals with normal blood glucose levels. METHODS:Cross-sectional data came from the baseline asse...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2018.05.005
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:No research to date has compared the beliefs of adolescents, parents and physicians with respect to type 1 diabetes mellitus self-care perceptions and barriers. This study examined how adolescents with type 1 diabetes, their parents and physicians perceive 4 key diabetes self-care behaviours (testing blood gl...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.02.057
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To enhance the dietary education presented to women with gestational diabetes (GDM) by exploring the reasons and experiences that women with GDM reported in making their food-choice decisions after receipt of dietary education from a healthcare professional. METHODS:Food Choice Map (FCM) semi-structured in-d...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.08.263
更新日期：2014-02-01 00:00:00
abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.jcjd.2017.02.003. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-busines...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.02.003
更新日期：2017-04-05 00:00:00
abstract：:Hyperglycemia is a significant cause of morbidity and mortality, often resulting in adverse outcomes. This review aimed to identify predictors of adverse outcomes, such as repeated hospital visits, hospitalization or death, in patients presenting to the emergency department (ED) with hyperglycemia. Electronic searches...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2018.11.008
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:Hypokalemia, a frequently cited complication of diabetic ketoacidosis (DKA) treatment, can have critical implications, including arrhythmias and death. We assessed the prevalence of hypokalemia and its associated factors in patients with DKA at our tertiary-care centre and identified opportunities to improve...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.10.002
更新日期：2016-06-01 00:00:00
abstract：:The most common presentation of chronic disease is multimorbidity. Disease management strategies are similar across most chronic diseases. Given the prevalence of multimorbidity and the commonality in approaches, fragmented single disease management must be replaced with integrated care of the whole person. The Albert...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2013.04.001
更新日期：2013-08-01 00:00:00
abstract：:Diabetic mastopathy is an uncommon, benign breast condition seen in type 1 and less frequently type 2 diabetic patients. It is characterized by a dense fibrous stromal proliferation of breast tissue, clinically mimicking cancerous masses, thus leading to worrisome investigations. Clinicians and pathologists must disti...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2013.12.008
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:East African (EA) women are a subpopulation who are at very high risk for gestational diabetes (GDM) and poor obstetric outcomes, but little is known about the care experiences of this understudied group. The objective of this study was to document the impact of a diagnosis of GDM and the perceptions of diab...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2018.01.013
更新日期：2018-12-01 00:00:00
abstract：:We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.02.007
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:To investigate the content, quality and popularity of information about type 2 diabetes available on YouTube. METHODS:We searched YouTube with the terms Diabetes, Diabetes type 2, Diabetes South Asians, Diabetes Punjabi and Diabetes Hindi to identify videos concerning type 2 diabetes. A team of health-care ...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.10.056
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:The balanced school day (BSD) is an alternative elementary school schedule whereby children have 2 20-minute eating periods instead of 1 20-minute lunch, as is found in the traditional schedule (TS). We assessed the glycated hemoglobin (A1C) levels of children with type 1 diabetes in the TS vs. the BSD becaus...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.07.005
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:Examining the diets of people living with type 2 diabetes may improve understanding of how diet affects disease progression. We derived dietary patterns in adults living with type 2 diabetes and explored associations among patterns, sociodemographic variables and cardiometabolic risk factors. METHODS:Dietar...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.11.006
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVES:To determine the long-term effects of changing the amount or source of dietary carbohydrate on quality of life (QOL), symptoms and dietary satisfaction in people with type 2 diabetes. METHODS:Subjects with diabetes treated by diet alone (n=162) were randomly assigned to high-carbohydrate/high-glycemic-index...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcjd.2016.08.223
更新日期：2017-04-01 00:00:00
abstract：:Diabetes mellitus is a disabling, chronic cardiovascular and medical disease with a tremendous health, social and economic burden in our ageing communities. It has a prevalence of 10% to 30% in people older than 65 years of age, and more than half of all subjects with diabetes in the United States are older than 60 ye...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.jcjd.2015.09.004
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVES:New-onsetdiabetes after transplant (NODAT) is a major contributor to cardiovascular disease after transplantation. Kidney transplantation (KT) recipients have low levels of exercise capacity. Resistance training (RT) might be of special benefit in this population because underlying disease and immunosuppress...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.08.014
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:With the expanding armamentarium of noninsulin therapies for type 2 diabetes mellitus, the use of insulin with various oral agents is becoming more common. In this study, we assessed the efficacy and cardiovascular (CV) safety of the dipeptidyl peptidase-4 inhibitor linagliptin as add-on to insulin in patient...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcjd.2015.06.010
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine whether perinatal outcomes differ between Caucasian and Asian subgroups of women with gestational diabetes mellitus (GDM) through use of standard vs ethnicity-specific birthweight curves. METHODS:This retrospective cohort study included 537 women with GDM, within the et...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2019.06.006
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVES:Individuals with type 1 diabetes try to manage the risk of exercise-induced hypoglycemia by either pre-exercise/pre-meal bolus insulin dose reductions and/or consuming additional carbohydrates during exercise. Both strategies have proven to be effective in offsetting hypoglycemia, but it remains unclear whic...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2020.03.003
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:To describe trends in blood glucose test strip (TS) utilization and cost in Saskatchewan. METHODS:A retrospective analysis of TS use between January 1, 1996, and December 31, 2013, was conducted using population-based health administrative databases in Saskatchewan. The prescription drug database was used t...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.01.004
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:The Goal Oriented controL of Diabetes in the Elderly populatioN (GOLDEN) Program assessed the management of older persons with type 2 diabetes in Canadian primary care. METHODS:Data were extracted from the records of 833 consecutively identified persons 65 years of age or older who had type 2 diabetes and we...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2017.03.003
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in p...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2015.01.004
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:The objective of the study was to describe the demographic and clinical characteristics of MedsCheck Diabetes (MCD) recipients in Ontario between program launch on September 1, 2010, and March 31, 2014. METHODS:This cohort study leveraged linked administrative claims data. Trends in MCD claims and recipient...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章
doi：10.1016/j.jcjd.2016.12.001
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:To investigate the support needs of elderly patients with diabetes and to classify elderly patients with diabetes living alone on the basis of support needs. METHODS:Support needs were derived from a literature review of relevant journals and interviews of outpatients as well as expert nurses in the field o...
journal_title：Canadian journal of diabetes
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcjd.2015.09.005
更新日期：2016-02-01 00:00:00
