Rate of Occult Neck Nodal Metastasis in Parotid Cancer: A Meta-Analysis.

Abstract:

BACKGROUND:The risk for occult neck nodal metastasis in carcinoma of the parotid gland is inconclusive. Therefore, addressing a negative neck prophylactically and the extent to do so remain controversial. This systematic review aimed to determine the rate of occult nodal metastasis for each neck level, and consequently, to elucidate the proper extent of elective neck dissection (END). METHODS:A meta-analysis of all studies that included patients with a diagnosis of parotid malignancies who underwent an END was performed. The risk for occult nodal metastasis was calculated for each neck level separately. RESULTS:The search strategy identified 124 papers from January 1980 to December 2019 in the various databases. Nine retrospective studies (n =548) met the inclusion criteria. The risk for occult neck nodal metastasis ranged from 0.0 to 9.43% with a random-effect model of 2.2% for level 1 (n =459), from 3.4 to 28.38% with a random-effect model of 16.51% for level 2 (n =548), from 0.0 to 21.63% with a random-effect model of 4.23% for level 3 (n =518), from 0.0 to 17.02% with a fixed-effect model of 0.39% for level 4 (n =310), and from 0.0 to 11.63% with a fixed-effect model of 1.7% for level 5 (n =417). CONCLUSION:The rate of occult neck nodal metastasis in parotid malignancies is low, with neck level 2 the most commonly involved. The results of this meta-analysis prevented the authors from substantiating the appropriate extent of an END in parotid cancer.

journal_name

Ann Surg Oncol

authors

Warshavsky A,Rosen R,Muhanna N,Ungar O,Nard-Carmel N,Abergel A,Fliss DM,Horowitz G

doi

10.1245/s10434-020-09331-7

subject

Has Abstract

pub_date

2020-11-11 00:00:00

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-020-09331-7

pub_type

杂志文章,评审
  • Cytoreductive surgery under aminolevulinic acid-mediated photodynamic diagnosis plus hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from ovarian cancer and primary peritoneal carcinoma: results of a phase I trial.

    abstract:BACKGROUND:We conducted a phase I clinical trial to evaluate the sensitivity, specificity, and safety of cytoreductive surgery (CRS) under aminolevulinic acid-mediated photodynamic diagnosis (ALA-PDD) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on 20 patients with peritoneal carcinomatosis (PC) from ovarian ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3901-5

    authors: Liu Y,Endo Y,Fujita T,Ishibashi H,Nishioka T,Canbay E,Li Y,Ogura S,Yonemura Y

    更新日期:2014-12-01 00:00:00

  • Trends in the surgical treatment of gastric adenocarcinoma.

    abstract:BACKGROUND:In past decade, the treatment of gastric adenocarcinoma has evolved as a result of the publication of two seminal randomized controlled trials. We aimed to examine treatment trends for resectable gastric cancer (stage I-III) using the National Cancer Data Base (NCDB). Our hypothesis was that the use of chemo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3314-x

    authors: Raigani S,Hardacre JM,Kim J,Ammori JB

    更新日期:2014-02-01 00:00:00

  • Treatment trends and factors associated with survival in T1aN0 and T1bN0 breast cancer patients.

    abstract:BACKGROUND:Breast conservation therapy (BCT) and adjuvant hormonal therapy for estrogen-receptor positive breast cancers have become standard of care. Our objectives were to evaluate trends in the surgical management and adjuvant therapy for early-stage breast cancer and to identify factors predicting survival. METHOD...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9441-5

    authors: Kennedy T,Stewart AK,Bilimoria KY,Patel-Parekh L,Sener SF,Winchester DP

    更新日期:2007-10-01 00:00:00

  • Readmission After Pancreaticoduodenectomy: The Influence of the Volume Effect Beyond Mortality.

    abstract:BACKGROUND:As increased focus is placed on quality of care in surgery, readmission is an increasingly important metric by which hospital and surgeon quality is measured. For complex pancreatic surgery, we hypothesized that increased pancreaticoduodenectomy (PD) volume may mitigate readmission rates. METHODS:The Univer...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4451-1

    authors: Sutton JM,Wilson GC,Wima K,Hoehn RS,Cutler Quillin R 3rd,Hanseman DJ,Paquette IM,Sussman JJ,Ahmad SA,Shah SA,Abbott DE

    更新日期:2015-11-01 00:00:00

  • Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.

    abstract:BACKGROUND:0.6-12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large, international, multicenter, case-control study, we compared the clinicopathologic features ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-011-2058-8

    authors: Murali R,Goumas C,Kricker A,From L,Busam KJ,Begg CB,Dwyer T,Gruber SB,Kanetsky PA,Orlow I,Rosso S,Thomas NE,Berwick M,Scolyer RA,Armstrong BK,GEM Study Group.

    更新日期:2012-03-01 00:00:00

  • Endoscopic therapy for Barrett's esophagus: a review of its emerging role in optimal diagnosis and endoluminal therapy.

    abstract::Barrett's esophagus (BE) is a premalignant lesion known to sequentially progress to esophageal adenocarcinoma. Management of BE has changed significantly over the last 5 years with the development of endoscopic resection and ablation, which has replaced esophagectomy as the treatment of choice in BE with high-grade dy...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-011-2163-8

    authors: Dunki-Jacobs EM,Martin RC

    更新日期:2012-05-01 00:00:00

  • Hypoxic single-pass isolated hepatic perfusion of hypotonic Cisplatin: safety study in the pig.

    abstract:BACKGROUND:Isolated hepatic perfusion (IHP) of chemotherapy has been proposed to deliver high doses of drug while avoiding systemic toxicity. Hypotonic cisplatin has a high in vitro activity on human colon cancer cells. We studied the safety of a 30-min hypoxic single-pass IHP with hypotonic cisplatin. METHODS:A preli...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0775-z

    authors: Ortega-Deballon P,Facy O,Consolo D,Magnin G,Tixier H,Simonet M,Rat P,Chauffert B

    更新日期:2010-03-01 00:00:00

  • Most pancreatic cancer resections are R1 resections.

    abstract:BACKGROUND:Curative resection has been shown to be one of the key factors influencing survival of pancreatic ductal adenocarcinoma (PDAC) patients. Although general guidelines for the processing of pancreatic specimens have been established, there is currently no widely accepted standardized protocol for pathological e...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-9839-8

    authors: Esposito I,Kleeff J,Bergmann F,Reiser C,Herpel E,Friess H,Schirmacher P,Büchler MW

    更新日期:2008-06-01 00:00:00

  • Young-onset rectal cancer: presentation, pattern of care and long-term oncologic outcomes compared to a matched older-onset cohort.

    abstract:BACKGROUND:Recent population-based studies have highlighted a disproportionate increase in the incidence of rectal cancer among adults younger than aged 50 years. To determine whether different intervention and surveillance strategies might be needed for younger patients, the patterns of care and oncologic outcomes amo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1674-7

    authors: You YN,Dozois EJ,Boardman LA,Aakre J,Huebner M,Larson DW

    更新日期:2011-09-01 00:00:00

  • Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough?

    abstract:BACKGROUND:Guidelines regarding specific resection margins for primary Merkel cell carcinoma (MCC) are not well established. The current National Comprehensive Cancer Network (NCCN) guidelines recommend 1- to 2-cm resection margins. This study aimed to determine the impact of margin width on local recurrence (LR), dise...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6688-y

    authors: Perez MC,de Pinho FR,Holstein A,Oliver DE,Naqvi SMH,Kim Y,Messina JL,Burke E,Gonzalez RJ,Sarnaik AA,Cruse CW,Wuthrick EJ,Harrison LB,Sondak VK,Zager JS

    更新日期:2018-10-01 00:00:00

  • Current issues in adjuvant treatment of stage II colon cancer.

    abstract:BACKGROUND:Adjuvant chemotherapy with 5-fluorouracil modulated by folinic acid, combined with oxaliplatin, has now become an accepted standard of care for patients with stage III colon cancer. In contrast, the use of adjuvant therapy for stage II patients remains controversial, and the identification of reliable progno...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/ASO.2006.07.003

    authors: André T,Sargent D,Tabernero J,O'Connell M,Buyse M,Sobrero A,Misset JL,Boni C,de Gramont A

    更新日期:2006-06-01 00:00:00

  • Intraoperative Ultrasound-Guided Lumpectomy Versus Mammographic Wire Localization for Breast Cancer Patients After Neoadjuvant Treatment.

    abstract:BACKGROUND:Intraoperative ultrasound (IOUS)-guided lumpectomy in early breast cancer has shown advantages over other techniques. However, the use of IOUS has been less explored after neoadjuvant treatment (NAT). This study aimed to compare IOUS- and wire localization (WL)-guided surgery in breast cancer patients after ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4935-z

    authors: Rubio IT,Esgueva-Colmenarejo A,Espinosa-Bravo M,Salazar JP,Miranda I,Peg V

    更新日期:2016-01-01 00:00:00

  • Development and evaluation of a checklist to support decision making in cancer multidisciplinary team meetings: MDT-QuIC.

    abstract:BACKGROUND:The quality of decision-making in cancer multidisciplinary team (MDT) meetings is variable, which can result in suboptimal clinical decision making. We developed MDT-QuIC, an evidence-based tool to support clinical decision making by MDTs, which was evaluated by key users. METHODS:Following a literature rev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-2187-0

    authors: Lamb BW,Sevdalis N,Vincent C,Green JS

    更新日期:2012-06-01 00:00:00

  • Preoperative aspartate aminotransferase to platelet ratio is an independent prognostic factor for hepatitis B-induced hepatocellular carcinoma after hepatic resection.

    abstract:BACKGROUND:There is conflicting evidence concerning platelet status and hepatocellular carcinoma (HCC) prognosis. We evaluated the prognostic value of platelet-based indices, including platelet count, platelet/lymphocyte ratio (PLR), and aspartate aminotransferase to platelet ratio index (APRI) in HCC after hepatic res...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3771-x

    authors: Shen SL,Fu SJ,Chen B,Kuang M,Li SQ,Hua YP,Liang LJ,Guo P,Hao Y,Peng BG

    更新日期:2014-11-01 00:00:00

  • Lobe-Specific Lymph Node Dissection for Clinical Early-Stage (cIA) Peripheral Non-small Cell Lung Cancer Patients: What and How?

    abstract:OBJECTIVE:We investigated the possible lobe-specific lymph node (LN) metastasis pattern of early-stage peripheral non-small cell lung cancers (NSCLC) and define the extent of lobe-specific LN dissection for them. METHODS:We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07926-3

    authors: Deng HY,Zhou J,Wang RL,Jiang R,Zhu DX,Tang XJ,Zhou Q

    更新日期:2020-02-01 00:00:00

  • Perspectives on the Costs of Cancer Care: A Survey of the American Society of Breast Surgeons.

    abstract:BACKGROUND:Cancer treatment costs are not routinely addressed in shared decisions for breast cancer surgery. Thus, we sought to characterize cost awareness and communication among surgeons treating breast cancer. METHODS:We conducted a self-administered, confidential electronic survey among members of the American Soc...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07594-3

    authors: Greenup RA,Rushing CN,Fish LJ,Lane WO,Peppercorn JM,Bellavance E,Tolnitch L,Hyslop T,Myers ER,Zafar SY,Hwang ES

    更新日期:2019-10-01 00:00:00

  • The illusion of the learning phase for lymphatic mapping.

    abstract:BACKGROUND:We provide a statistical analysis of the learning phase for sentinel node biopsy. METHODS:Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02557365

    authors: Tanis PJ,Nieweg OE,Hart AA,Kroon BB

    更新日期:2002-03-01 00:00:00

  • Prognosis and Circumferential Margin in Patients with Resected Hilar Cholangiocarcinoma.

    abstract:BACKGROUND:Resection margin status is a known prognosticator in patients who undergo resection for hilar cholangiocarcinoma. However, the influence of an isolated positive circumferential margin on clinical outcome is unclear. METHODS:Patients with resected de novo hilar cholangiocarcinoma from two European hepatobili...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09105-1

    authors: Stremitzer S,Stift J,Laengle J,Schwarz C,Kaczirek K,Jones RP,Quinn LM,Fenwick SW,Diaz-Nieto R,Poston GJ,Malik HZ

    更新日期:2020-09-10 00:00:00

  • Effect of growth hormone on tumor and host in an animal model.

    abstract:BACKGROUND:The relative effects of growth hormone on tumor versus host growth and protein metabolism are not known. This study examines the influence of recombinant rat growth hormone (r-rGH) on host and tumor growth, host body composition, and protein synthesis of tumor and host in tumor-bearing rats. METHODS:After l...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303570

    authors: Wolf RF,Ng B,Weksler B,Burt M,Brennan MF

    更新日期:1994-07-01 00:00:00

  • Cancer antigen 125 associated with multiple benign and malignant pathologies.

    abstract:BACKGROUND:Cancer antigen (CA) 125 tumor-associated antigen is a high molecular glycoprotein used for follow-up of epithelial ovarian cancer. The test is often requested as a differential diagnosis in patients with pleural or peritoneal fluid. This study analyzes the prevalence of CA-125 increases in a population of pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/aso.2003.05.015

    authors: Miralles C,Orea M,España P,Provencio M,Sánchez A,Cantos B,Cubedo R,Carcereny E,Bonilla F,Gea T

    更新日期:2003-03-01 00:00:00

  • Management of locoregional and systemic recurrence of breast cancer: to stage or not to stage and how.

    abstract::The surveillance of breast cancer patients after potentially curative treatment may result in the identification of locoregional or distant recurrence. While many patients expect frequent imaging studies to monitor for recurrence, there are no data supporting aggressive imaging surveillance beyond mammography. However...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3180-6

    authors: Leitch AM

    更新日期:2013-10-01 00:00:00

  • Functional down-regulation of beta1 and beta2 integrins of lamina propria lymphocytes (LPL) and tumor-infiltrating lymphocytes (TIL) in colorectal cancer patients.

    abstract::Integrins play an important role in various lymphocyte functions. In this study, we isolated lamina propria lymphocytes (LPL) and tumor-infiltrating lymphocytes (TIL) from normal and malignant tissues in patients with colorectal cancer, and examined the expression of beta1 and beta2 integrins on these lymphocytes quan...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-999-0500-y

    authors: Kitayama J,Tuno N,Nakayama H,Shibata Y,Muto T,Nagawa H

    更新日期:1999-07-01 00:00:00

  • Immediate Reconstruction in Inflammatory Breast Cancer: Challenging Current Care.

    abstract:BACKGROUND:Inflammatory breast cancer (IBC) is an aggressive disease that is treated with trimodality therapy consisting of neoadjuvant chemotherapy, surgery, and post-mastectomy radiation therapy (PMRT). Traditionally, modified radical mastectomy without reconstruction has been the operation of choice for patients wit...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5554-z

    authors: Simpson AB,McCray D,Wengler C,Crowe JP,Djohan R,Tendulkar R,O'Rourke C,Grobmyer SR,Valente SA

    更新日期:2016-12-01 00:00:00

  • Complications After Major Surgery for Duodenopancreatic Neuroendocrine Tumors in Patients with MEN1: Results from a Nationwide Cohort.

    abstract:BACKGROUND:Little is known about complications after major duodenopancreatic surgery for duodenopancreatic neuroendocrine tumors (dpNETs) in multiple endocrine neoplasia type 1 (MEN1). Therefore, the incidence and severity of complications after major surgery for MEN1-related dpNETs were assessed. METHODS:Patients wer...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09496-1

    authors: van Beek DJ,Nell S,Vorselaars WMCM,Bonsing BA,van Eijck CHJ,van Goor H,Nieveen van Dijkum EJ,Dejong CHC,Valk GD,DutchMEN Study Group (DMSG).,Borel Rinkes IHM,Vriens MR

    更新日期:2021-01-31 00:00:00

  • Sentinel lymph node mapping for thick (>or=4-mm) melanoma: should we be doing it?

    abstract:BACKGROUND:Thick (>or=4-mm) primary melanomas are believed to be associated with a high incidence of occult distant metastases. The use of sentinel lymph node (SLN) mapping and biopsy in the treatment lesions has been questioned. METHODS:A retrospective review of a computerized database identified 114 patients who und...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/aso.2003.03.055

    authors: Carlson GW,Murray DR,Hestley A,Staley CA,Lyles RH,Cohen C

    更新日期:2003-05-01 00:00:00

  • Impact of tumor grade on prognosis in pancreatic cancer: should we include grade in AJCC staging?

    abstract:BACKGROUND:AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1071-7

    authors: Wasif N,Ko CY,Farrell J,Wainberg Z,Hines OJ,Reber H,Tomlinson JS

    更新日期:2010-09-01 00:00:00

  • Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration.

    abstract:BACKGROUND:Male breast cancer accounts for less than 1% of all breast cancers, yet males have a worse prognosis than females with breast cancer. METHODS:Using the 1988-2003 Surveillance, Epidemiology, and End Results Program data, we conducted a retrospective, population-based cohort study to investigate stage-specifi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1468-3

    authors: Gnerlich JL,Deshpande AD,Jeffe DB,Seelam S,Kimbuende E,Margenthaler JA

    更新日期:2011-07-01 00:00:00

  • Clinical and socioeconomic factors influence treatment decisions in Graves' disease.

    abstract:BACKGROUND:Definitive treatment of Graves' disease includes radioactive iodine (RAI) and thyroidectomy, but utilization varies. We hypothesize that, in addition to clinical reasons, there are socioeconomic factors that influence whether a patient undergoes thyroidectomy or RAI. METHODS:Patients treated for Graves' dis...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4095-6

    authors: Elfenbein DM,Schneider DF,Havlena J,Chen H,Sippel RS

    更新日期:2015-04-01 00:00:00

  • Intraoperative imprint cytology examination of sentinel lymph nodes after neoadjuvant chemotherapy in breast cancer patients.

    abstract:BACKGROUND:Intraoperative imprint cytology (IC) is one of several accurate, proven methods to detect tumor cells in sentinel lymph nodes (SLN) from patients with operable breast cancer. In patients treated with neoadjuvant chemotherapy (NAC), studies have demonstrated the feasibility and accuracy of SLN biopsy procedur...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0952-0

    authors: Gimbergues P,Dauplat MM,Durando X,Abrial C,Le Bouedec G,Mouret-Reynier MA,Cachin F,Kwiatkowski F,Tchirkov A,Dauplat J,Penault-Llorca F

    更新日期:2010-08-01 00:00:00

  • Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis.

    abstract:BACKGROUND:Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. METHODS:The cohort study included Kaiser Permanente members who were long-term (≥5 years) rectal...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6017-x

    authors: Alavi M,Wendel CS,Krouse RS,Temple L,Hornbrook MC,Bulkley JE,McMullen CK,Grant M,Herrinton LJ

    更新日期:2017-11-01 00:00:00