Abstract:
BACKGROUND:Increasing physical activity (PA) and reducing sedentary behaviour (SB) have been associated with healthy ageing, but their effects when adjusted for reverse causation and selection bias remain unclear. METHODS:A deficits accumulation (DA) index based on the number and severity of 51 health deficits (0-100%) was calculated at baseline and three biannual follow-up visits, in a representative cohort of 3 228 community-dwelling older adults in Spain. Average differences in DA index by previous recreational PA, household PA, mentally-active SB and passive SB were estimated using marginal structural models with inverse probability of exposure and censoring weights. RESULTS:Compared with participants with previous recreational PA of 10-19.9 metabolic equivalent hours/week (MET-hours/week), average differences in DA index (95% confidence intervals) were 0.19 (-1.09, 1.48), 0.69 (-0.23, 1.61), -0.66 (-1.34, 0.02), -0.87 (-1.59, -0.13) and -0.55 (-1.37, 0.28) for 0, 0.1-9.9, 20-29.9, 30-39.9 and ≥40 MET-hours/week, respectively (P for trend = 0.006). Household PA showed no effect on subsequent DA after adjusting for reverse causation. Women, but not men, who spent 7-14.9, 15-20.9 and ≥21 h/week on mentally active SB had DA decreases of 0.09 (-1.00, 1.19), 1.08 (-0.28, 2.45) and 2.17 (0.58, 3.75), respectively, compared with 1-6.9 h/week (P for trend = 0.005); whereas women who spent 3-3.9, 4-4.9 and ≥5 h/day on passive SB showed DA increases of 0.41 (-0.52, 1.35), 1.35 (0.13, 2.57) and 2.13 (0.78, 3.47), respectively, compared with 2-2.9 h/day (P for trend = 0.001). CONCLUSIONS:The proposed methodology allows estimation of the causal effects of PA and SB on ageing, by simulating a random assignment in which all subjects have the same probability of exposure.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
García-Esquinas E,Ortolá R,Martínez-Gómez D,Damián J,Prina M,Rodríguez-Artalejo F,Pastor-Barriuso Rdoi
10.1093/ije/dyaa228subject
Has Abstractpub_date
2020-11-05 00:00:00eissn
0300-5771issn
1464-3685pii
5956331pub_type
杂志文章abstract:BACKGROUND:Small-for-gestational-age (SGA) birth is commonly used as a proxy for fetal growth restriction, but also includes constitutionally small infants. Genetic factors account for almost half of the risk of SGA birth. We estimated perinatal risks of SGA birth using both population-based and within-sibling analyses...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy196
更新日期:2019-02-01 00:00:00
abstract::Kersa HDSS was established in 12 sub-districts of Kersa district, Eastern Hararge, Oromia Region, Ethiopia. The site is principally rural with two small towns (Kersa and Weter). The baseline census was conducted in 2007 and since then has been updated every 6 months, with registration of demographic and health events....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv284
更新日期:2016-02-01 00:00:00
abstract::Mortality rates from ischaemic heart disease (IHD) in Australia for the period 1969-78 have been analysed by place of residence, occupation and country of birth. Large variations were found among subpopulations. Throughout the period IHD mortality was lowest among professional and farming occupations and highest among...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.1.25
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:During the past decades a widening of the relative gap in death rates between upper and lower socioeconomic groups has been reported for several European countries. Although differential mortality decline for cardiovascular diseases has been suggested as an important contributory factor, it is not known what...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/dyg209
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Child feeding recommendations include breastfeeding beyond 12 months, however, some researchers have reported increased rates of malnutrition in breastfed toddlers. A negative association between growth and breast-feeding may reflect reverse causality; that is, the outcome (growth) is a determinant of the pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.2.349
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contri...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyg107
更新日期:2003-10-01 00:00:00
abstract::Seemingly contradictory data support controversies concerning the relationships between food intake and illnesses. The present study of 1035 adults, aged 30-39 years, shows that (1) daily energy intake is not higher in obese than in non-obese people, (2) obesity is more prevalent in social groups where energy intake i...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.3.571
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:In 2009, there were 8273 local screening laboratories, 254 confirmatory laboratories, 35 provincial confirmatory central laboratories and 1 National AIDS Reference Laboratory (NARL) in China. These laboratories were located in Center for Disease Control and Prevention (CDC) facilities, hospitals, blood donat...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq224
更新日期:2010-12-01 00:00:00
abstract::Aboriginal communities have a high prevalence of upper and lower respiratory tract disease. One thousand two hundred and eighty seven West Australian Aborigines and 265 non-Aborigines were examined. Twenty nine per cent of Aborigines had lower respiratory tract abnormalities. Amongst 635 Aboriginal children less than ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.1.105
更新日期:1983-03-01 00:00:00
abstract::Cardiovascular disease risk factor and mortality data collected since the 1978 Conference on the Decline in Coronary Heart Disease Mortality were reviewed. Risk factor and disease trends were generally parallel and compatible with current hypotheses of cause and prevention. A few discrepancies between risk factors and...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Computerized record linkage is commonly used in cohort studies to ascertain the study outcome, and as such its accuracy classifying the outcome can be described using the standard epidemiological terms of sensitivity and positive predictive value (PPV). METHOD:We describe a 'duplicate method' to calculate t...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/31.6.1246
更新日期:2002-12-01 00:00:00
abstract::In 1983 and 1984, surveys were conducted in four Chinese population samples, urban and rural for both Beijing and Guangzhou, as part of PRC-USA collaborative research in cardiovascular and cardiopulmonary epidemiology. Serum total cholesterol (TC), HDL-cholesterol (HDL-C), and triglycerides (TG) were measured in 4280 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.5.893
更新日期:1992-10-01 00:00:00
abstract::Coronary heart disease (CHD) is regarded as a disease of developed 'western' societies. Within developed societies, however, CHD is typically a disease of the less affluent socioeconomic classes. This has not always been the case. Forty years ago. CHD was reported to be more common among the upper social classes. In N...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.393
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Recent communications have argued that often it may not be appropriate to analyse cross-sectional studies of prevalent outcomes with logistic regression models. The purpose of this communication is to compare three methods that have been proposed for application to cross sectional studies: (1) a multiplicati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.1.91
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Contact sports have high rates of injury. Protective equipment regulations are widely used as an intervention to reduce injury risk. The purpose of this study was to investigate the injury prevention effect of regulations governing protective equipment in two full-body contact sports. METHODS:Injury rates i...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/31.3.587
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Transforming growth factor-beta1 (TGFbeta1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFbeta1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh102
更新日期:2004-10-01 00:00:00
abstract::Quantitative bias analysis serves several objectives in epidemiological research. First, it provides a quantitative estimate of the direction, magnitude and uncertainty arising from systematic errors. Second, the acts of identifying sources of systematic error, writing down models to quantify them, assigning values to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu149
更新日期:2014-12-01 00:00:00
abstract::Analyses were made of the relation between maternal alcohol consumption before and in early pregnancy and five infant outcome variables: birthweight, crown-heel length, occipitofrontal circumference and the Apgar scores at 1 and 5 minutes. The data were analysed for all centres combined and separately. From tabulation...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/21.supplement_1.s45
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Several studies have shown that inactivated, whole-cell oral cholera vaccines (OCVs) confer both direct protection on vaccinees and herd protection on populations. Because our earlier cluster-randomized effectiveness trial (CRT) in urban Bangladesh failed to detect OCV herd protection, we reanalysed the tria...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyz060
更新日期:2019-08-01 00:00:00
abstract::Methodological issues concerning the collection and analysis of daily morbidity data in community studies in developing countries are discussed. The effects of recall period and inter-observer variation on symptom prevalence are considered in the context of a longitudinal study in The Gambia, in which prevalence fell ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.4.757
更新日期:1994-08-01 00:00:00
abstract::In a population-based cohort study in Southern Brazil, 87.3% of 5914 liveborn infants were followed for over 12 months. The 215 infant deaths occurring in this cohort were studied in relation to birthweight, gestational age and socioeconomic status. Causes of death were ascertained through the review of case notes and...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.2.239
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:A growing body of literature suggests that physical activity may be a protective factor against hip fracture. METHODS:To study the association between hip fracture risk and recreational physical activity at various ages, changes in activity during adult life, occupational physical activity and how risks var...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.2.308
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The Italian Longitudinal Study on Aging (ILSA) evaluates the rates of diabetes, cardiovascular and neurological disorders in a random sample of 5632 Italians aged 65-84 years. METHODS:The ILSA has two components: a first screening phase administered to all participants, that includes a personal interview, p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.5.995
更新日期:1997-10-01 00:00:00
abstract::Geographical variations in the declining rates of ischaemic heart disease (IHD) mortality may provide clues about various environmental risk factors responsible as a mass influence on the population IHD rate. The rate of IHD decline in 18 of 21 NJ counties was 2 to 45% less than the USA national rate of decline. The o...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.1.26
更新日期:1990-03-01 00:00:00
abstract::A person to person outbreak of hepatitis A is described: 90 cases of hepatitis A occurred in a small town in Calabria, southern Italy; all cases were under 18 years of age with the highest age-specific incidence rate in the 6-10 year age group. Transmission was identified by tracing close contacts with other incubatin...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.1.108
更新日期:1986-03-01 00:00:00
abstract::Selection bias remains a more difficult bias to understand than confounding or measurement error. Past definitions have not always been illuminating and a simple method (such as the change-in-estimate method for confounding) has not been available to determine its presence and magnitude in the study sample. A better u...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy138
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Knowing the starting date of the BSE epidemic and its size at the very beginning is crucial to interpret the timing of the nvCJD cases and to forecast the nvCJD epidemic. The first cases occurred in 1985. The models devised by Anderson (back-calculation) and Dealler (age-period-cohort) led to an estimate of ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.3.526
更新日期:1999-06-01 00:00:00
abstract::Mortality rates for cancers of 13 sites in 34 countries were analysed using two data reduction techniques, factor and cluster analysis. Factor analysis identified two independent underlying factors which appear to influence cancer mortality patterns. The first factor, which appears to be related to affluence, may repr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.4.501
更新日期:1987-12-01 00:00:00
abstract::This paper contains part of the results of a repetitive and comprehensive analysis of accidents among bus drivers. In a series of articles different aspects of the aetiology of bus drivers' accidents will be highlighted. The results presented indicate a strong negative association of experience with accident risk, mod...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.1.35
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear. METHODS:We conducted a population-based cohort study via linkage of Swe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt152
更新日期:2014-02-01 00:00:00