Abstract：
:Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established hypoxia-inducible factor (HIF)-EPO axis and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Watts D,Gaete D,Rodriguez D,Hoogewijs D,Rauner M,Sormendi S,Wielockx Bdoi
10.3390/ijms21218131subject
Has Abstractpub_date
2020-10-30 00:00:00issue
21issn
1422-0067pii
ijms21218131journal_volume
21pub_type
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