Abstract:
INTRODUCTION:The potential effect of adipokines on the development of AF is yet to be established. The aim of this study was to investigate the association of baseline serum adipokines with 1) the presence of AF at baseline and 2) future risk of AF development. MATERIAL AND METHODS:The current study is a sub-analysis of the prospective, randomised AVOCADO (Aspirin Vs./Or Clopidogrel in Aspirin-resistant Diabetics inflammation Outcomes) trial. The AVOCADO study included patients with type 2 DM burdened with at least two additional cardiovascular risk factors and receiving acetylsalicylic acid. In patients included in the current analysis adipokines and inflammatory biomarker levels were measured. Information on the subsequent AF diagnosis was collected after a median of 5.4 years of follow-up. RESULTS:A total of 273 patients with type 2 DM (median age 68 years; 52% male) were included in the initial analysis comparing patients with and without AF at baseline. Patients with diagnosed AF (12%) had higher levels of serum resistin [8.5 (5.8-10.5) vs. 6.9 (5.6-8.7) ng/mL; p = 0.034], adiponectin [6.9 (5.6-8.7) vs. 2.7 (1.8-4.2) ng/mL; p = 0.032], and N-terminal pro-B-type natriuretic peptide [336 (148-473) vs. 108 [45-217]; p < 0.001) than non-AF patients. There were no significant differences in serum leptin, IL-6, and TNF-alpha concentrations between the two groups. From subjects without known AF at study entry, 19% developed AF at follow-up. In logistic regression analysis, baseline adipokine levels did not predict AF development. CONCLUSION:In type 2 DM, patients with AF have higher resistin and adiponectin concentrations than patients with no AF. None of the studied adipokines proved a predictor of future AF development.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Peller M,Kapłon-Cieślicka A,Rosiak M,Tymińska A,Ozierański K,Eyileten C,Kondracka A,Mirowska-Guzel D,Opolski G,Postuła M,Filipiak KJdoi
10.5603/EP.a2019.0059subject
Has Abstractpub_date
2020-01-01 00:00:00pages
34-41issue
1eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/64672journal_volume
71pub_type
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journal_title:Endokrynologia Polska
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doi:
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journal_title:Endokrynologia Polska
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journal_title:Endokrynologia Polska
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doi:
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journal_title:Endokrynologia Polska
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doi:
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journal_title:Endokrynologia Polska
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更新日期:2013-01-01 00:00:00
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journal_title:Endokrynologia Polska
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更新日期:2018-01-01 00:00:00
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journal_title:Endokrynologia Polska
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doi:
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更新日期:2007-05-01 00:00:00
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journal_title:Endokrynologia Polska
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doi:
更新日期:2007-09-01 00:00:00
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