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Memory in low-grade glioma patients treated with radiotherapy or Temozolomide. A correlative analysis of EORTC study 22033-26033.

Abstract：

BACKGROUND:EORTC study 22033-26033 showed no difference in progression-free survival between high-risk low-grade glioma receiving either radiotherapy (RT) or Temozolomide (TMZ) chemotherapy alone as primary treatment. Considering the potential long-term deleterious impact of radiotherapy on memory functioning, this study aims to determine whether TMZ is associated with less impaired memory functioning. METHODS:Using the Visual Verbal Learning Test (VVLT), memory functioning was evaluated at baseline and subsequently every 6 months. Minimal compliance for statistical analyses was set at 60%. Conventional indices of memory performance (VVLT Immediate Recall, Total Recall, Learning Capacity, and Delayed Recall) were used as outcome measures. Using a mixed linear model memory functioning was compared between treatment arms and over time. RESULTS:Neuropsychological assessment was performed in 98 patients ( 53 RT, 46 TMZ). At 12 months compliance had dropped to 66%, restricting analyses to baseline, 6 months, and 12 months. At baseline, patients in either treatment arm did not differ in memory functioning, gender, age, or educational level. Over time, patients in both arms showed improvement in Immediate Recall (p = 0.017) and total number of words recalled (Total Recall; p < 0.001, albeit with delayed improvement in radiotherapy patients (group by time; p = 0.011). Memory functioning was not associated with radiotherapy gross, clinical, or planned target volumes. CONCLUSION:In patients with high-risk low-grade glioma there is no indication that in the first year after treatment radiotherapy has a deleterious effect on memory function when compared to TMZ chemotherapy.

journal_name

Neuro Oncol

journal_title

Neuro-oncology

authors

Klein M,Drijver AJ,van den Bent MJ,Bromberg JC,Hoang-Xuan K,Taphoorn MJB,Reijneveld JC,Ben Hassel M,Vauleon E,Eekers DBP,Tzuk-Shina T,Lucas A,Freixa SV,Golfinopoulos V,Gorlia T,Hottinger AF,Stupp R,Baumert BG

doi

10.1093/neuonc/noaa252

subject

Has Abstract

pub_date

2020-11-01 00:00:00

eissn

1522-8517

issn

1523-5866

pii

5948535

pub_type

杂志文章

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Memory in low-grade glioma patients treated with radiotherapy or Temozolomide. A correlative analysis of EORTC study 22033-26033.