Tranexamic acid is associated with decreased transfusion, hospital length of stay, and hospital cost in simultaneous bilateral total knee arthroplasty.

Abstract:

:Tranexamic acid (TXA) reduces blood loss and transfusion rates in unilateral total knee arthroplasty (TKA), but there is limited data regarding its efficacy in bilateral TKA. This study reports the impact TXA has on clinical outcomes and hospital cost of care in simultaneous, primary bilateral TKA. The 449 patients were retrospectively reviewed. Primary outcomes included the rates of allogeneic and autologous blood transfusion. Secondary outcomes included hospital length of stay (HLOS), post-hospital discharge disposition, 30-day thromboembolic events (TEE), and mean hospital cost of care. Total direct medical costs were obtained from an institutional research database and adjusted to nationally representative unit costs in 2013 inflation-adjusted dollars. Our study revealed that in patients undergoing simultaneous bilateral TKA, TXA use was associated with reduced allogeneic (OR 0.181, 95% CI 0.090-0.366, p<0.001) and combined allogeneic and autologous transfusion rates (OR 0.451, 95% CI 0.235-0.865, p=0.017). TXA was associated with a HLOS reduction of 0.9 days (β-coefficient -0.582, 95% CI -1.008- -0.156, p=0.008), an increased likelihood of hospital discharge over skilled nursing facility (SNF) (OR 2.25, 95% CI 1.117-4.531, p=0.023) and reduced total hospital cost of care by 6.45% (p<0.001), room and board costs by 11.76% (p<0.001), and transfusion costs by 81.65% (p<0.001). In conclusion, TXA use in bilateral TKA is associated with lower blood transfusion rates, reduced hospital length of stay, reduced cost of hospital care and skilled nursing facility avoidance.

journal_name

Bosn J Basic Med Sci

authors

D'Souza R,Duncan C,Whiting D,Brown M,Warner M,Smith H,Kremers H,Stewart T

doi

10.17305/bjbms.2020.5060

subject

Has Abstract

pub_date

2020-10-27 00:00:00

eissn

1512-8601

issn

1840-4812

pub_type

杂志文章
  • MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers.

    abstract::Spermatogenesis is a tightly controlled, multi-step process in which mature spermatozoa are produced. Disruption of regulatory mechanisms in spermatogenesis can lead to male infertility, various diseases of male reproductive system, or even cancer. The spermatogenic impairment in infertile men can be associated with d...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2018.3477

    authors: Khawar MB,Mehmood R,Roohi N

    更新日期:2019-02-12 00:00:00

  • Treatment benefits on metabolic syndrome with diet and physical activity.

    abstract::The research has included 422 patients aged between 25 to 60, of whom 341 were men and 81 women. The purpose of research was to determine impact of diet and physical activity in the treatment of metabolic syndrome during the six month period. Processing of results through descriptive and discriminative analysis have i...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2718

    authors: Dragusha G,Elezi A,Dragusha S,Gorani D,Begolli L

    更新日期:2010-05-01 00:00:00

  • Treatment options for thoracolumbar spine fractures.

    abstract::A decision for operative versus nonoperative management of thoracolumbar fractures should NEVER be based solely on one factor. Only after a thorough physical, neurological, and spinal examination, and an assessment of a patient's prior activity, social and educational background and patient's expectations, one should ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2005.3279

    authors: Karaiković EE,Pacheco HO

    更新日期:2005-05-01 00:00:00

  • Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia.

    abstract::The glutathione S-transferase (GST) genes encode enzymes that mediate the detoxification of xenobiotics by catalyzing the conjugation of glutathione (GSH) to xenobiotic substrates. The aim of the current study is to investigate the association between GSTT1 and GSTM1 polymorphisms and chronic myeloid leukemia (CML) am...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4176

    authors: Muddathir ARM,Abdallah EI,Khabour OF,Abdelgader RE,Elgari MM

    更新日期:2019-04-15 00:00:00

  • Lung 99mTc-MIBI scintigraphy: impact on diagnosis of solitary pulmonary nodule.

    abstract::Most of today available non-invasive procedures cannot clearly determinate between benign and malignant solitary pulmonary nodules (SPN). The purpose of the study was to assess the possibility of using 99mTc labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) to differentiate benign from malignant SPN. Sixty pati...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2011.2570

    authors: Nikoletic K,Lucic S,Peter A,Kolarov V,Zeravica R,Srbovan D

    更新日期:2011-08-01 00:00:00

  • Inhibition of Neutral red photolysis with different antioxidants.

    abstract::Neutral red is a dye the azine structure which has been used as an acido-base indicator and a dye in histochemistry. In 1960 Goldhaber introduced Neutral red into the medium of resorbing bone cultures to localize the osteoclast in the living cultures. Using time-lapse microcinematography in order to follow the osteocl...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2007.3091

    authors: Rimpapa Z,Sofić E,Sapcanin A,Toromanović J,Tahirović I

    更新日期:2007-02-01 00:00:00

  • Bladder outlet obstruction number: a good indicator of infravesical obstruction in patients with benign prostatic enlargement?

    abstract::The objective of our study was to evaluate bladder outlet obstruction number (BOON) in order to predict infravesical obstruction in patients with benign prostatic enlargement (BPE). Two hundred patients with proven BPE from daily urological practice at the Urology Department of the Sarajevo University Clinical Centre ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2012.2459

    authors: Aganovic D,Spahovic H,Prcic A,Hadziosmanovic O

    更新日期:2012-08-01 00:00:00

  • MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).

    abstract::MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2376

    authors: Tong F,Ying Y,Pan H,Zhao W,Li H,Zhan X

    更新日期:2018-08-01 00:00:00

  • In which regions is breast-feeding safer from the impact of toxic elements from the environment?

    abstract::Owing to its unique nutritional and immunological characteristics, breast milk is the most important food source for infants. But, children are at greater risk for exposure to environmental toxicants from breast milk. The aim of this study was to evaluate the influence of environmental pollution on essential and toxic...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2011.2556

    authors: Cinar N,Ozdemir S,Yucel O,Ucar F

    更新日期:2011-11-01 00:00:00

  • Analysis of risk factors, localization and 30-day prognosis of intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage is the deadliest, most disabling and least treatable form of stroke despite progression in medical science. The aim of the study was to analyze the frequency, risk factors, localization and 30-day prognosis in patients with intracerebral hemorrhage. We analyzed 352 patients with intracerebral ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2964

    authors: Smajlović D,Salihović D,C Ibrahimagić O,Sinanović O,Vidović M

    更新日期:2008-05-01 00:00:00

  • Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells.

    abstract::C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the production of atherosclerosis-re-lated factors in cultured human coronary...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4711

    authors: Zhang Y,Cao H

    更新日期:2020-11-02 00:00:00

  • Femoro-popliteal bypass above knee with saphenous vein vs synthetic graft.

    abstract::There is still debate whether sintethic graft (polytetrafluoroethylene or Dacron) is equivalent to vein as bypass graft material for the above-knee femoropopliteal bypass. Therefore, we performed prospective randomized trial to compare vein with polytetrafluoroethylene/dacron for femoropopliteal bypasses with the dist...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.17305/bjbms.2008.2899

    authors: Solaković E,Totić D,Solaković S

    更新日期:2008-11-01 00:00:00

  • Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia.

    abstract::Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between bipolar disorder a...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2012.2446

    authors: Oruč L,Kapur-Pojskić L,Ramić J,Pojskić N,Bajrović K

    更新日期:2012-11-01 00:00:00

  • Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.

    abstract::Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Mature epithelial tissues originate from different embryonic germ layers. The objective of this research was to explore the presence and localization of TFF3 peptide in mouse embryonic epithelia and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.1838

    authors: Bijelić N,Belovari T,Tolušić Levak M,Baus Lončar M

    更新日期:2017-08-20 00:00:00

  • Does dental caries affect dental development in children and adolescents?

    abstract::Although a link between dietary changes, caries, and dental development has been observed, the literature provides little insight about this relationship. The aim of our study was to investigate the association between dental caries and dental development in a clinical sample of Albanian children and adolescents. In t...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2841

    authors: Dhamo B,Elezi B,Kragt L,Wolvius EB,Ongkosuwito EM

    更新日期:2018-05-20 00:00:00

  • Epileptic psychoses - evaluation of clinical aspects.

    abstract::Epileptic psychoses as the most complex psychopathological phenomena represent unexplored states for prognosis. Clinical trials, conveyed in order to found risk factors still are not consistent in their conclusions. By this research results of all biological, clinical, psychological and social, as well as demographic ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2007.3069

    authors: Fiseković S,Burnazović L

    更新日期:2007-05-01 00:00:00

  • Insulin resistance and C-reactive protein in preeclampsia.

    abstract::Preeclampsia is referred to as the "disease of the theories" because of the multiple hypotheses proposed to explain is occurrence. Despite considerable research, the causes of preeclampsia remain unclear. Preeclampsia is likely to be multifactorial in origin, and recent research has focused on endothelial dysfunction ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2813

    authors: Stefanović M,Vukomanović P,Milosavljević M,Kutlesić R,Popović J,Tubić-Pavlović A

    更新日期:2009-08-01 00:00:00

  • Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.

    abstract::The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hyperte...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.17305/bjbms.2014.2295

    authors: Liu P,Zhang H,Tang Y,Sheng C,Liu J,Zeng Y

    更新日期:2014-02-01 00:00:00

  • The importance of using peritoneal equlibration test for the peritoneal transport type characterization in continuous ambulatory peritoneal dialysis patients.

    abstract::The aim of this study was to analyze the importance of the peritoneal equilibration test (PET) in evaluation of the peritoneal membrane transport status in patients treated with continuous ambulatory peritoneal dialysis (CAPD). The study included 30 adult continuous ambulatory peritoneal dialysis (CAPD) patients, 16 m...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2645

    authors: Uncanin S,Rasić S,Rebić D,Dzemidzić J,Muslimović A,Begović B,Herenda V

    更新日期:2010-04-01 00:00:00

  • Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus.

    abstract::This is the first study performed in population from Bosnia & Herzegovina (BH), in which we analysed a significance of genetic variations in drug-metabolising enzyme, cytochrome P450 (CYP), in pathogenesis of Type 2 diabetes. We have determined allele frequencies for CYP2C9*2, CYP2C19*2, and CYP2D6*4 in diabetic patie...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2662

    authors: Semiz S,Dujic T,Ostanek B,Prnjavorac B,Bego T,Malenica M,Marc J,Causevic A

    更新日期:2010-11-01 00:00:00

  • High Ki-67 expression is associated with prolactin secreting pituitary adenomas.

    abstract::Pituitary adenomas represent the third most common primary intracranial tumor in neurosurgical practice. To understand the biological behaviour of the pituitary adenomas previous studies have determined the tumor proliferation rate using monoclonal antibodies targeted against the Ki-67 antigen. The aim of this study w...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.1750

    authors: Bălinişteanu B,Cîmpean AM,Ceauşu AR,Corlan AS,Melnic E,Raica M

    更新日期:2017-05-20 00:00:00

  • Injection pressure as a marker of intraneural injection in procedures of peripheral nerves blockade.

    abstract::The blockade of peripheral nerves carries a certain risk of unwanted complications, which can follow after unintentional intraneural injection of a local anesthetic. Up till today, the research of measuring injection pressure has been based on animal models, even though the histological structure of periphery nerve is...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3107

    authors: Vucković I,Dilberović F,Kulenović A,Divanović KA,Voljevica A,Kapur E

    更新日期:2006-11-01 00:00:00

  • Echocardiographic evaluation of cardiac function in female patients with thyroid disorders.

    abstract::The aim of this study was to assess echocardiographic changes in female patients with untreated dysfunctional thyroid states and whether the therapy aimed to normalize the thyroid dysfunction could lead to improvement in cardiac systolic and diastolic function. The study included 90 female subjects who performed contr...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2704

    authors: Hadzović-Dzuvo A,Kucukalić-Selimović E,Nakas-Ićindić E,Rasić S,Begić A,Al Tawil D,Valjevac A,Avdagić N,Lepara O

    更新日期:2010-05-01 00:00:00

  • Frequency and characteristics of side effects associated with antidepressant drugs.

    abstract::Depression is among the most common of chronic health problems. WHO report predicts that depression will be the leading cause of disability in the industrial world by the year 2020. To be successful, treatment for the patients suffering from depression must be continued until complete recovery, but most patients do no...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2002.3575

    authors: Kusturica J,Zulić I,Loga-Zec S,Mulabegović N,Loga S,Kapić E

    更新日期:2002-12-01 00:00:00

  • Trends of incidence and prognosis of upper tract urothelial carcinoma.

    abstract::The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.5345

    authors: Wu J,Chen S,Wu X,Mao W,Wang Y,Xu B,Zheng D,Chen M

    更新日期:2020-12-18 00:00:00

  • Significance of specificity of Tinetti B-POMA test and fall risk factor in third age of life.

    abstract::As for the third age, psychophysical abilities of humans gradually decrease, while the ability of adaptation to endogenous and exogenous burdens is going down. In 1987, "Harada" et al. (1) have found out that 9.5 million persons in USA have difficulties running daily activities, while 59% of them (which is 5.6 million...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2006.3210

    authors: Avdić D,Pecar D

    更新日期:2006-02-01 00:00:00

  • Fixed combination lisinopril plus hydro-chlorothiazide in the treatment of essential arterial hypertension: an opened, multi-centre, prospective clinical trial.

    abstract::The aim of this trial was to examine the efficacy and safety of antihypertensive fixed combination lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd) in the treatment of essential arterial hypertension. In our trial we included 297 patients, aged 54.65+/-9.6 years, with treated or untreated hypertension and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.17305/bjbms.2007.3031

    authors: Gerc V,Begović B,Vehabović M,Voronkov LG,Vataman E,Musić L,Buksa M,Kusljugić Z,Ilyash MG,Ena LM,Tchelujko VI,Dyaduk AI,Bagrij AE,Andrievskaja SA,Vehabović A,Knezević B,Hima F

    更新日期:2007-11-01 00:00:00

  • Changes in serum homocysteine level follow two different trends in patients during early post myocardial infarction period.

    abstract::The evolution of homocysteine (Hcy) changes after acute myocardial infarction is still not elucidated. Serum Hcy concentration has been shown to increase between acute and convalescent period after myocardial infarction and stroke. Also a decrease in serum Hcy during acute phase was observed. It is still not clear whe...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2837

    authors: Valjevac A,Dzubur A,Nakas-Ićindić E,Hadzović-Dzuvo A,Zaćiragić A,Lepara O,Arslanagić A

    更新日期:2009-05-01 00:00:00

  • Neurostructural correlates of strength decrease following total knee arthroplasty: A systematic review of the literature with meta-analysis.

    abstract::Recent literature suggests that alterations in both neural and structural components of the neuromuscular system are major determinants of knee extensor muscle weakness after total knee arthroplasty (TKA). Therefore, the goal of this study was to investigate the maximal voluntary strength (MVS), voluntary muscle activ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,meta分析

    doi:10.17305/bjbms.2019.3814

    authors: Paravlic AH,Kovač S,Pisot R,Marusic U

    更新日期:2020-02-05 00:00:00

  • Transcranial Doppler sonography as diagnostic method.

    abstract::Having in mind the fact that cerebrovascular disease (CVB) takes today in medicine, in spite of diagnostic and therapeutic modernisation, the third place of mortality causes in the world (behind cordial and malignant diseases, but in front of depressions), and the second place of invalidity cause (right after trauma) ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2002.3585

    authors: Delilović-Vranić J

    更新日期:2002-12-01 00:00:00