Abstract:
:Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving mediator (SPM) concentrations are linked with both DMARD responsiveness and disease pathotype. Machine learning analysis demonstrates that baseline plasma concentrations of resolvin D4, 10S, 17S-dihydroxy-docosapentaenoic acid, 15R-Lipoxin (LX)A4 and n-3 docosapentaenoic-derived Maresin 1 are predictive of DMARD responsiveness at 6 months. Assessment of circulating SPM concentrations 6-months after treatment initiation establishes that differences between responders and non-responders are maintained, with a decrease in SPM concentrations in patients resistant to DMARD therapy. These findings elucidate the potential utility of plasma SPM concentrations as biomarkers of DMARD responsiveness in RA.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Gomez EA,Colas RA,Souza PR,Hands R,Lewis MJ,Bessant C,Pitzalis C,Dalli Jdoi
10.1038/s41467-020-19176-zsubject
Has Abstractpub_date
2020-10-27 00:00:00pages
5420issue
1issn
2041-1723pii
10.1038/s41467-020-19176-zjournal_volume
11pub_type
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