Abstract:
Objectives:Residual hip dysplasia is the most common underlying condition leading to secondary osteoarthritis (OA) of the hip. Subchondral bone alterations in OA secondary to hip dysplasia (HD-OA) are poorly investigated. The aim of the present study was to analyse the microarchitecture, bone remodelling and pathological alterations of subchondral bone in femoral heads from patients with HD-OA. Methods:Subchondral bone specimens were extracted from both weight-bearing and non-weight-bearing regions of femoral heads from 20 patients with HD-OA and 20 patients with osteoporotic femoral neck fracture, during hip replacement surgery. Micro-CT and histological examination were performed to assess the microarchitecture and histopathological changes. Results:The weight-bearing subchondral bone showed significantly more sclerotic microarchitecture and higher bone remodelling level in HD-OA as compared with osteoporosis. In the non-weight-bearing region, the two diseases shared similar microarchitectural characteristics, but higher bone remodelling level was detected in HD-OA. Distinct regional differences were observed in HD-OA, whereas the two regions exhibited similar characteristics in osteoporosis. In addition, HD-OA displayed more serious pathological alterations, including subchondral bone cyst, metaplastic cartilaginous tissue, bone marrow oedema and fibrous tissue, especially in the weight-bearing region. Conclusions:Osteoarthritic deteriorations of subchondral bone induced by hip dysplasia spread throughout the whole joint, but exhibit region-dependent variations, with the weight-bearing region more seriously affected. Biomechanical stress might exert a pivotal impact on subchondral bone homeostasis in hip dysplasia. The translational potential of this article:The histomorphometric findings in the project indicate an early intervention for the development of hip dysplasia in clinic.
journal_name
J Orthop Translatjournal_title
Journal of orthopaedic translationauthors
Li G,Chen L,Zheng Q,Ma Y,Zhang C,Zheng MHdoi
10.1016/j.jot.2019.10.014subject
Has Abstractpub_date
2019-11-20 00:00:00pages
190-197eissn
2214-031Xissn
2214-0328pii
S2214-031X(19)30226-8journal_volume
24pub_type
杂志文章abstract:Background and objective:Restoring the shoulder function is a crucial demand of patients with rotator cuff (RC) tears. Most preclinical studies only focused on biological and mechanical measurements. Functional assessment was less investigated in the preclinical studies. This study aims to review the literature of shou...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2020.02.012
更新日期:2020-03-23 00:00:00
abstract:Background:The purposes of this study were to develop a machine learning-based implant recognition program and to verify its accuracy. Methods:Postoperative anteroposterior (AP) X-rays (≥300 dpi) were collected of patients who underwent total hip arthroplasty. X-rays with a wire or plate added and those without a true...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.11.004
更新日期:2019-12-20 00:00:00
abstract::Stem cells are considered to be one of the greatest potential treatments to cure degenerative diseases. Stem cells injection for knee osteoarthritis (OA) is still a relatively new treatment and has not yet gained popularity. So, the effectiveness, safety and potential of mesenchymal stem cells (MSCs) for knee OA treat...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2020.03.015
更新日期:2020-04-27 00:00:00
abstract::Collapse of the femoral head is the most significant pathogenic complication arising from osteonecrosis of the femoral head. It is related to the disruption of the maintenance of cartilage and bone, and results in an impaired function of the vascular component. A method for predicting the collapse of the femoral head ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2016.11.002
更新日期:2017-01-10 00:00:00
abstract::Tendinopathy is a common disease of the musculoskeletal system, particularly in athletes and sports amateurs. In this review, we will present evidence for the critical role of inflammatory mediators and immunocytes in the pathogenesis of tendinopathy and the efficacy of current antiinflammatory therapy and regenerativ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2018.03.003
更新日期:2018-04-14 00:00:00
abstract::Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle-induced osteolysis. These pathological conditions are associated with inflammatory responses, suggesting the contribution of inflammation to bo...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2017.05.002
更新日期:2017-05-23 00:00:00
abstract:Background/Objective:The purpose of this study was to evaluate supraspinatus tenocyte viability and metabolism in explants exposed to various local anaesthetics and corticosteroids. Our hypothesis was that the tendons exposed to these common injectates would have significantly decreased cell viability and metabolism co...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2016.08.002
更新日期:2016-09-28 00:00:00
abstract:Purpose:Young and physically active patients have mainly received metal-on-metal (MoM) total hip arthroplasty (THA) and resurfacing hip arthroplasty (RHA). However, the correlation between daily physical activity (PA) levels, serum-ion concentrations of chromium and cobalt and pseudotumours formation of patients who un...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2018.11.001
更新日期:2018-12-17 00:00:00
abstract:Background:A promising approach of bone repair is to use stem cells, such as mesenchymal stem cells (MSCs). Seeking available source of MSCs still remains a great challenge in tissue engineering and cell therapy. Peripheral blood (PB) emerges as an alternative source of MSCs which can be easily acquired with minimal in...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.02.003
更新日期:2019-03-07 00:00:00
abstract:Background:The microbiomechanical properties of the meniscus influence the cell response to the surrounding biomechanical environment and are beneficial to understand meniscus repairing and healing. To date, however, this information remains ambiguous. This study aims to characterise the microbiomechanical properties ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.06.003
更新日期:2019-08-08 00:00:00
abstract::The medical system of Hong Kong has been heavily affected by COVID-19. Adaptations are necessary to continue clinical care, education, and research, while minimising the risk of infection of our staff and students. Here, we report our early experience in response to the challenge posed by the COVID-19 pandemic. The t...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2020.08.001
更新日期:2020-11-01 00:00:00
abstract:Objective:The aim of the study is to explore the clinical effect of a dynamic condylar screw (DCS) system, medial anatomical buttress plate (MABP), and autogenous iliac bone graft through the Watson-Jones approach in the treatment of femoral neck nonunion. Methods:This prospective study included 15 patients (12 men an...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.04.004
更新日期:2019-04-28 00:00:00
abstract::[This corrects the article DOI: 10.1016/j.jot.2017.02.001.]. ...
journal_title:Journal of orthopaedic translation
pub_type: 已发布勘误
doi:10.1016/j.jot.2017.12.005
更新日期:2018-02-03 00:00:00
abstract::Lumbar laminectomy often results in failed back surgery syndrome. Most scholars support the three-dimensional theory of adhesion: Fibrosis surrounding the epidural tissues is based on the injured sacrospinalis behind, fibrous rings and posterior longitudinal ligaments. Approaches including using the minimally invasive...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2018.02.001
更新日期:2018-03-07 00:00:00
abstract:Objective:Variation of the solute diffusion within articular cartilage is an important feature of osteoarthritis (OA) progression. For in vitro study of monitoring of the diffusion process, it is essential to simulate physiological conditions as much as possible. Our objective was to investigate the effects of loading ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.10.013
更新日期:2019-11-20 00:00:00
abstract:Background/Objective:Artificial bone models (ABMs) are used in orthopaedics for research of biomechanics, development of implants and educational purposes. Most of the commercially available ABMs approximate the morphology of Europeans, but they may not depict the Asian anatomy. Therefore, our aim was to develop the fi...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.10.004
更新日期:2019-11-04 00:00:00
abstract:Background/Objective:Hydrogen gas cavity is formed during in vivo degradation of magnesium implants. In many studies, the gas cavity is mostly punctured out subcutaneously. However, this procedure becomes inapplicable in certain internal surgeries; therefore, the effect of this gas cavity is worth further assessment. ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2015.08.003
更新日期:2015-08-20 00:00:00
abstract:Background/objective:In anterior cruciate ligament reconstruction, a tendon graft, anchored by interference screws (IFSs), is frequently used as a replacement for the damaged ligament. Generally, IFSs are classified as being either metallic or polymeric. Metallic screws have sharp threads that lacerate the graft, prev...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.09.003
更新日期:2019-10-14 00:00:00
abstract:Background/Objective:Osteoarthritis is a common chronic disease of the joints characterised by the degeneration of articular cartilages and subchondral bone. The most common diagnostic imaging used clinically is X-ray; however, it cannot directly image cartilage. Magnetic resonance imaging (MRI) is well suited for cart...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2015.07.003
更新日期:2015-08-28 00:00:00
abstract:Background:Prosthetic joint infection (PJI) is the most serious total joint arthroplasty (TJA) complication despite several aseptic and antiseptic preventive measures. There is no clear evidence or even consensus, whether antibiotic-loaded bone cement (ALBC) should be used, in addition to systemic short-term routine an...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2020.04.005
更新日期:2020-05-08 00:00:00
abstract:Background/Objective:In a rat meniscal tear model of osteoarthritis (OA), a full-thickness cut in the medial meniscus leads to joint instability and progressive development of knee OA. This study evaluated in vivo high-resolution three-dimensional magnetic resonance imaging (3D MRI) in demonstrating the knee joint stru...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2015.06.002
更新日期:2015-06-23 00:00:00
abstract::The top issue in tissue engineering is how to obtain more seed cells quickly and to preserve their characteristic morphology during in vitro expansion culture of cells. Microcarriers can help to amplify cell numbers and maintain the appropriate phenotype for tissue repair and restoration of function. In addition, micr...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2015.02.003
更新日期:2015-03-13 00:00:00
abstract:Background:Abnormal bone formation in subchondral bone resulting from uncoupled bone remodeling is considered a central feature in osteoarthritis (OA) pathogenesis. H-type vessels can couple angiogenesis and osteogenesis. We previously revealed that elevated H-type vessels in subchondral bone were correlated with OA an...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2020.04.008
更新日期:2020-05-19 00:00:00
abstract:Objective:The antibacterial activity of copper (Cu)-alloy biomaterials has shown a great potential in clinical application. Here, we evaluated the osteogenesis and antibacterial effects of Ti6Al4V-6.5wt%Cu alloy in an in vivo model of infected bone defects and determine their responsible proteins and pathways using pro...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2020.10.004
更新日期:2020-12-28 00:00:00
abstract::Corporate establishment of US Food & Drug Administration approved pulsed electromagnetic fields (PEMFs) for clinical applications has been achieved. However, optimization of PEMFs for improvement in efficacy for current indications, in addition to the expansion into new indications, is not trivial. Moving directly int...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章,评审
doi:10.1016/j.jot.2017.02.006
更新日期:2017-03-31 00:00:00
abstract:Object:To compare the clinical and radiological outcomes of O-arm navigation assisted percutaneous pedicle fixation and open freehand pedicle fixation in treatment of AO type A3 thoracolumbar burst fractures (TBFs) without neurological deficit. Methods:This retrospective study involved 72 patients with type A3 TBFs wh...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2019.11.002
更新日期:2019-12-05 00:00:00
abstract:Objectives:Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellular and molecular level, osteoarthritis (OA) is characterised by alterat...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2017.12.004
更新日期:2018-01-02 00:00:00
abstract:Background:Despite intensive research, regeneration of articular cartilage largely remains an unresolved medical concern as the clinically available modalities still suffer from long-term inconsistent data, relatively high failure rates and high prices of more promising approaches, such as cell therapy. In the present ...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2018.08.003
更新日期:2018-09-09 00:00:00
abstract:Objectives:To evaluate the biomechanical performance of the Femoral Neck System (FNS) versus the Hansson Pin System (Hansson Pins) with two parallel pins in a Pauwels II femoral neck fracture model with posterior comminution. Methods:Forty-degree Pauwels II femoral neck fractures AO 31-B2.1 with 15° posterior wedge we...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2020.06.002
更新日期:2020-07-22 00:00:00
abstract:Background:Osteoarthritis (OA) is the most common degenerative joint disorder. Inflammatory cytokine plays an important role in OA progression. Previous studies have demonstrated that ginsenoside Rb1 would prevent inflammation and apoptosis in chondrocytes. However, we have not found any animal study reporting that Rb1...
journal_title:Journal of orthopaedic translation
pub_type: 杂志文章
doi:10.1016/j.jot.2016.03.001
更新日期:2016-03-31 00:00:00