Abstract：
:ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins. ADAM9 influences the developmental process, inflammation, and degenerative diseases. Recently, increasing evidence has shown that ADAM9 plays an important role in tumor biology. Overexpression of ADAM9 has been found in several cancer types and is correlated with tumor aggressiveness and poor prognosis. In addition, through either proteolytic or non-proteolytic pathways, ADAM9 promotes tumor progression, therapeutic resistance, and metastasis of cancers. Therefore, comprehensively understanding the mechanism of ADAM9 is crucial for the development of therapeutic anti-cancer strategies. In this review, we summarize the current understanding of ADAM9 in biological function, pathophysiological diseases, and various cancers. Recent advances in therapeutic strategies using ADAM9-related pathways are presented as well.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chou CW,Huang YK,Kuo TT,Liu JP,Sher YPdoi
10.3390/ijms21207790subject
Has Abstractpub_date
2020-10-21 00:00:00issue
20issn
1422-0067pii
ijms21207790journal_volume
21pub_type
杂志文章,评审abstract：:Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by devastating alterations to the cardiac conduction system as well as the structure of the atria. AF can lead to decreased cardiac function, heart failure, and other complications. Long non-coding RNAs (lncRNAs) have been shown t...
journal_title：International journal of molecular sciences
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更新日期：2020-07-30 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-03-07 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-12-09 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-01-12 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-04-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-14 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms19041008
更新日期：2018-03-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-05-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms131114219
更新日期：2012-11-05 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112269
更新日期：2017-10-28 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20174166
更新日期：2019-08-26 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-07-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2011-01-20 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-07-12 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-12-23 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-07-16 00:00:00
abstract：BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21249765
更新日期：2020-12-21 00:00:00
