Abstract:
:The wound healing process is characterized by varied biological and molecular cascades including inflammation, tissue proliferation, and remodeling phase. To augment and maintain these cascades, an all-natural matrix system is proposed. Biocompatible biopolymers, sodium alginate and gelatin, were employed to prepare microfibers via extrusion-gelation into a physical crosslinking solution. Curcumin, an anti-inflammatory, anti-oxidant and wound healing agent, was loaded into the fibers as a natural bioactive compound. Curcumin-loaded composite microfibers and blank microfibers were fabricated using biopolymers such as sodium alginate and gelatin. The formulation batches were coded as A1G9-A10G0 according to the varied concentrations of sodium alginate and gelatin. The molecular transitions within the composite microfibers were characterized using FTIR and were further corroborated using molecular mechanics analysis. In mechanical properties tensile strength and elongation-at-break (extensibility) were ranging between 1.08 ± 0.01 to 3.53 ± 0.41 N/mm2 and 3.89 ± 0.18 to 0.61 ± 0.03%. The morphological analysis confirmed the formation and fabrication of the microfibers. In addition, physical evaluation including matrix degradation and entrapment efficiency was performed to give a comparative account of various formulations. The water uptake capacity of the blank and curcumin-loaded composite fibers was found to be in the range of 30.77 ± 2.17 to 100.00 ± 5.99 and 22.34 ± 1.11 to 56.34 ± 4.68, respectively. Composite microfibers presented a cumulative release of 85% in 72 h, confirming the prolonged release potential of the composite fibers. The drug release followed an anomalous (non-Fickian) release behavior asserting the role of degradation and diffusion. In an in vivo full-thickness cutaneous wound model, the composite microfibers provided higher degree of contraction 96.89 ± 3.76% as compared to the marketed formulation (Vicco turmeric cream). In conclusion, this all-natural, alginate-gelatin-curcumin composite has the potential to be explored as a cost-effective wound healing platform.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Sharma A,Mittal A,Puri V,Kumar P,Singh Idoi
10.1007/s13205-020-02453-5subject
Has Abstractpub_date
2020-11-01 00:00:00pages
464issue
11eissn
2190-572Xissn
2190-5738pii
2453journal_volume
10pub_type
杂志文章相关文献
3 Biotech文献大全abstract::The present study investigated the role of colchicine in the treatment of RSV infection. Treatment of BEAS-2B cells following RSV infection with colchicine caused a significant decrease in the number of viral plaques. In RSV-infected BEAS-2B cells' treatment with colchicine leads to a significant up-regulation of both...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1917-z
更新日期:2019-11-01 00:00:00
abstract::The molecular physiology of milk production of two important dairy species; Sahiwal cows (Bos indicus) and Murrah buffaloes (Bubalus bubalis) are not fully understood due to constraints in obtaining mammary tissue samples because of sacred and ethical reasons. The present study suggests the use of milk-derived mammary...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1642-7
更新日期:2019-03-01 00:00:00
abstract::Pectin derived from plant waste sources is currently focused as an economical and eco-friendly approach. Optimization of pectin extraction from muskmelon peel by response surface methodology (RSM) was investigated in this study. Box-Behnken Design (BBD) was used to identify the optimal level of the extraction variable...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0655-3
更新日期:2017-05-01 00:00:00
abstract::Nine (9) different date palm (Phoenix dactylifera L.) cultivars from UAE, which differ in their flower timings were selected to determine the polymorphism and genetic relationship between these cultivars. Hereditary differences and interrelationships were assessed utilizing inter-simple sequence repeat (ISSR) and dire...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1108-3
更新日期:2018-02-01 00:00:00
abstract::Metatranscriptomics, a subset of metagenomics, provides valuable information about the whole gene expression profiling of complex microbial communities of an ecosystem. Metagenomic studies mainly focus on the genomic content and identification of microbes present within a community, while metatranscriptomics provides ...
journal_title:3 Biotech
pub_type: 杂志文章,评审
doi:10.1007/s13205-020-2057-1
更新日期:2020-02-01 00:00:00
abstract::In this study, we systemically investigated the positions and orientations of matrix attachment regions (MARs) in expression vectors to fully explore the mechanism for improving transgene expression. We constructed 14 vectors that incorporated human β-globin MARs into pIRES-eGFP backbone vectors. The MARs flanked the ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1971-6
更新日期:2019-11-01 00:00:00
abstract::The present study was evaluated to test the potential of plant growth-promoting actinobacteria in increasing seed mineral density of chickpea under field conditions. Among the 19 isolates of actinobacteria tested, significant (p < 0.05) increase of minerals over the uninoculated control treatments was noticed on all t...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-016-0458-y
更新日期:2016-12-01 00:00:00
abstract::Chemically unique environment of endophytes makes them to have various adaptive mechanisms for survival. One of such mechanisms involves the production of pharmacologically significant plant-specific metabolites. In the present study, 26 endophytic fungi were isolated from stem of Bacopa monnieri (L.) Wettst. plants. ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0788-4
更新日期:2017-07-01 00:00:00
abstract::Parthenium hysterophorus is a noxious weed in America, Asia, Africa and Australia. This weed is considered to be a cause of allergic respiratory problems, contact dermatitis, mutagenicity in human and livestock. Crop production is drastically reduced owing to its allelopathy. Also aggressive dominance of this weed thr...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-011-0007-7
更新日期:2011-07-01 00:00:00
abstract::Hydrogen production by biological route is a potentially sustainable alternative. Nowadays, energy production from sustainable sources has become urgent for several countries as well as for international policies. In this perspective, hydrogen has gained substantial global attention as clean, sustainable, and versatil...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1676-x
更新日期:2019-04-01 00:00:00
abstract::Genetic polymorphism amid plant species is a crucial factor for plant improvement and maintaining their biodiversity. Evaluation of genetic diversity amongst plant species is significant to deal with the environmental stress conditions and their effective involvement in the breeding programs. Hence, in present study, ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1736-2
更新日期:2019-06-01 00:00:00
abstract::Kalopanax septemlobus is a medicinal woody species of the family Araliaceae, and the pharmaceutical properties of saponins obtained from K. septemlobus suggest that K. septemlobus has the potential to be a crude drug and dietary health supplement. In this study, we established cell suspension culture of K. septemlobus...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1090-9
更新日期:2018-01-01 00:00:00
abstract::We have isolated three novel strains of Trichoderma (two T. harzianum and one T. atroviride) from wild mushroom and tree bark, and evaluated their biocontrol potential against Sclerotium delphinii infecting cultivated cotton seedlings. T. harzianum strain CICR-G, isolated as a natural mycoparasite on a tree-pathogenic...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-013-0150-4
更新日期:2014-06-01 00:00:00
abstract::In the present study, the growth conditions and accumulation of ectoines (ectoine and hydroxyectoine) by Paludifilum halophilum DSM 102817T under salt stress conditions have been investigated. The productivity assay of this strain for ectoines revealed that the highest cellular content was reached in the minimal gluco...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02512-x
更新日期:2020-12-01 00:00:00
abstract::A high-salt-tolerant strain, Meyerozyma guilliermondii, has been isolated from activated sludge which has a great effect in the treatment of high-salt wastewater. To identify the salt tolerance mechanism of the strain, transcriptome sequencing and fluorescence quantitative PCR were used to analyse and compare the thal...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-019-1817-2
更新日期:2019-07-01 00:00:00
abstract::The bacterial strain producing thermostable, alklophilic alpha-amylase was identified as Bacillus amyloliquefaciens KCP2 using 16S rDNA gene sequencing data (NCBI Accession No: KF112071). Medium components were optimized through the statistical approach for the synthesis of alpha-amylase by the organism under solid-st...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-014-0213-1
更新日期:2015-04-01 00:00:00
abstract::Today, the role of nanotechnology in human life is undeniable as a broad range of industries, particularly food and medicine sectors, have been dramatically influenced. Nanomaterials can contribute to food safety by forming new nano-sized ingredients with modified physicochemical characteristics. Nanotechnologies can ...
journal_title:3 Biotech
pub_type: 杂志文章,评审
doi:10.1007/s13205-020-02409-9
更新日期:2020-10-01 00:00:00
abstract::Glycoprotein D (gD) of Herpes Simplex Virus-2 is used as an antigen in various anti-herpes subunit vaccines owing to its involvement in binding the host cell receptors for host infectivity. However, most of these monomeric protein based candidates have shown low immunogenicity in animal models. To enhance the immunoge...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-02452-6
更新日期:2020-11-01 00:00:00
abstract::Bacterial strains associated with entomopathogenic nematodes (EPNs) Rhabditis (Oscheius) spp. were isolated from infected cadavers of Galleria mellonella. The obtained 18 isolates were subdivided into nine phylogenetically different genera based on comparative sequence analysis of their 16S rRNA genes. The isolates we...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-015-0326-1
更新日期:2016-06-01 00:00:00
abstract::An efficient regeneration system via a combined pathway of organogenesis and somatic embryogenesis was developed for date palm (Phoenix dactylifera L.) cv. Mejhoul. Adventitious buds were obtained from shoot-tip explants with a frequency of 53.3% after 9 months of culture: 6 months on half-strength Murashige and Skoog...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1235-x
更新日期:2018-04-01 00:00:00
abstract::The complex nature of marine biodiversity is partially responsible for the lack of studies in Indian ascidian species, which often target a small number of novel biomolecules. We performed untargeted metabolomics using gas chromatography-mass spectrometry (GC-MS) in two invasive ascidian species to investigate the int...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1273-4
更新日期:2018-05-01 00:00:00
abstract::Current study describes the green, environmental friendly, and cost-effectiveness technique for the preparation of MgO nanoparticles (NPs) via white button mushroom aqueous extract. The synthesized MgO NPs were characterized using equipments such as X-ray diffraction, dynamic light scattering (DLS), scanning electron ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0894-3
更新日期:2017-08-01 00:00:00
abstract::Long-term production in commercial straw biogas plants has been rare in China due to inefficiencies in the logistics stream. Biomass densification could be a potential solution to this issue. Therefore, we conducted a study to evaluate whether biomass densification is a more efficient and sustainable option. We perfor...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-0914-3
更新日期:2017-10-01 00:00:00
abstract::Phosphoglucomutase (PGM) is a key enzyme in glycolysis and gluconeogenesis, regulating both glycogen and trehalose metabolism in insects. In this study, we explored the potential function of phosphoglucomutase (PGM) using RNA interference technology in Nilaparvata lugens, the brown planthopper. PGM1 and PGM2 were foun...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-2053-5
更新日期:2020-02-01 00:00:00
abstract::Significant efforts are being directed towards the improvement of rice using genetic manipulations. A good and reproducible system for recovering fertile Indica rice plants is imperative. The aim of this study was to study the influence of initial cell density on growth dynamics of suspension cultures. The cultures we...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1213-3
更新日期:2018-04-01 00:00:00
abstract::In the current study, the production of novel glutaminase free l-asparaginase from a new microbial source (Pseudomonas resinovorans IGS-131) is reported. Optimization of l-asparaginase production using conventional and statistical optimization techniques resulted in an enzyme yield of 37.63 IU/mL, which was 3.45-fold ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-020-2135-4
更新日期:2020-04-01 00:00:00
abstract::Lysine-rich (Lys-rich) proteins encoded by AGP17, AGP18, and AGP19 genes are cell wall-associated glycopeptides related to sexual reproduction in flowering plants. This subclass belongs to classical arabinogalactan proteins (AGPs) widely studied in model plants like Arabidopsis. In this study, we identified the CaAGP1...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-017-1031-z
更新日期:2018-01-01 00:00:00
abstract::Cyclodextrin glucanotransferase (CGTase, EC. 2.1.1.19) produced using new alkaliphile Microbacterium terrae KNR 9 has been purified to homogeneity in a single step by the starch adsorption method. The specific activity of the purified CGTase was 45 U/mg compared to crude 0.9 U/mg. This resulted in a 50-fold purificati...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-016-0495-6
更新日期:2016-12-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer in the world. Tobacco chewing is implicated with most of the cases of HNSCC but this type of cancer is increasing in non-tobacco chewers as well. This study was instigated to provide comprehensive variant and gene-level data in HNSC...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-014-0267-0
更新日期:2015-10-01 00:00:00
abstract::In this work we evaluated methanolic extracts from different parts (leaves, seeds, fruit peel and pulp) of Chamaerops humilis L. for antioxidant activity and the ability to inhibit enzymes linked with neurodegenerative diseases: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (TYR). The total ...
journal_title:3 Biotech
pub_type: 杂志文章
doi:10.1007/s13205-018-1110-9
更新日期:2018-02-01 00:00:00