Abstract:
:Chrysanthemum virus B encodes a multifunctional p12 protein that acts as a transcriptional activator in the nucleus and as a suppressor of RNA silencing in the cytoplasm. Here, we investigated the impact of p12 on accumulation of major classes of small RNAs (sRNAs). The results show dramatic changes in the sRNA profiles characterised by an overall reduction in sRNA accumulation, changes in the pattern of size distribution of canonical siRNAs and in the ratio between sense and antisense strands, lower abundance of siRNAs with a U residue at the 5'-terminus, and changes in the expression of certain miRNAs, most of which were downregulated.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Vetukuri RR,Kalyandurg PB,Saripella GV,Sen D,Gil JF,Lukhovitskaya NI,Grenville-Briggs LJ,Savenkov EIdoi
10.1007/s00705-020-04832-ysubject
Has Abstractpub_date
2020-12-01 00:00:00pages
2953-2959issue
12eissn
0304-8608issn
1432-8798pii
10.1007/s00705-020-04832-yjournal_volume
165pub_type
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