Abstract：
:Multi-Drug Resistant (MDR) Pseudomonas aeruginosa is one of the most important bacterial pathogens that causes infection with a high mortality rate due to resistance to different antibiotics. This bacterium prompts extensive tissue damage with varying factors of virulence, and its biofilm production causes chronic and antibiotic-resistant infections. Therefore, due to the non-applicability of antibiotics for the destruction of P. aeruginosa biofilm, alternative approaches have been considered by researchers, and phage therapy is one of these new therapeutic solutions. Bacteriophages can be used to eradicate P. aeruginosa biofilm by destroying the extracellular matrix, increasing the permeability of antibiotics into the inner layer of biofilm, and inhibiting its formation by stopping the quorum-sensing activity. Furthermore, the combined use of bacteriophages and other compounds with anti-biofilm properties such as nanoparticles, enzymes, and natural products can be of more interest because they invade the biofilm by various mechanisms and can be more effective than the one used alone. On the other hand, the use of bacteriophages for biofilm destruction has some limitations such as limited host range, high-density biofilm, sub-populate phage resistance in biofilm, and inhibition of phage infection via quorum sensing in biofilm. Therefore, in this review, we specifically discuss the use of phage therapy for inhibition of P. aeruginosa biofilm in clinical and in vitro studies to identify different aspects of this treatment for broader use.
journal_name
Ann Clin Microbiol Antimicrobjournal_title
Annals of clinical microbiology and antimicrobialsauthors
Chegini Z,Khoshbayan A,Taati Moghadam M,Farahani I,Jazireian P,Shariati Adoi
10.1186/s12941-020-00389-5subject
Has Abstractpub_date
2020-09-30 00:00:00pages
45issue
1issn
1476-0711pii
10.1186/s12941-020-00389-5journal_volume
19pub_type
杂志文章,评审abstract：BACKGROUND:Penicillium sp., other than P. marneffei, is an unusual cause of invasive disease. These organisms are often identified in immunosuppressed patients, either due to human immunodeficiency virus or from immunosuppressant medications post-transplantation. They are a rarely identified cause of infection in immun...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-4-21
更新日期：2005-12-21 00:00:00
abstract：BACKGROUND:Hepatotoxicity is one of the most serious complications of highly active antiretroviral therapy (HAART). The aim of this report is to analyse an HIV infected patient on HAART including nevirapine and taking antidepressive agents, with acute toxic hepatitis. CASE PRESENTATION:A 39 year old patient diagnosed ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-1-1
更新日期：2002-09-16 00:00:00
abstract：BACKGROUND:Disinfection, antisepsis and sterilization (DAS) practices are of critical importance in hospital practice. This study aims to investigate the daily DAS practices of private hospitals in Istanbul, Turkey. METHODS:The DAS practices of 155 private hospitals in Istanbul province were investigated using a quest...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-015-0073-5
更新日期：2015-03-19 00:00:00
abstract：BACKGROUND:Empiric antimicrobial therapy (EAMT) using imipenem/colistin is commonly prescribed as a first line therapy in critically ill patients with severe sepsis. We aimed to assess the appropriateness of prescribing imipenem/colistin as EAMT in ICU patients. METHODS:A 3-year observational prospective study include...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-018-0292-7
更新日期：2018-11-16 00:00:00
abstract：:Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-11-6
更新日期：2012-03-11 00:00:00
abstract：BACKGROUND:Multidrug resistant Pseudomonas aeruginosa harbours integrons and other mobile genetic elements such as plasmids and transposons, which easily disseminate antibiotic resistance genes among clinical strains of P. aeruginosa. METHODOLOGY:Plasmid extraction of 54 clinical isolates of P. aeruginosa was carried ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-12-29
更新日期：2013-10-21 00:00:00
abstract：INTRODUCTION:The aim of this study was to show the emergence of the qnrD gene among fluoroquinolone-resistant Morganella morganii isolate. The occurrence of mutations in DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC,parE) genes was also investigated in this strain. METHODOLOGY:95 clinical Enterobacteria were s...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-014-0034-4
更新日期：2014-08-09 00:00:00
abstract：BACKGROUND:Carbapenemase-producing Klebsiella pneumoniae (CPKP) strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the circulating clones and analyze the clinical and molecular characteristics of CPKP in our hospital. METHODS:A total of 74 carbapenemase producers col...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-015-0109-x
更新日期：2016-01-19 00:00:00
abstract：BACKGROUND:Tuberculous spondylitis (Pott's disease) is an ancient human disease. Because it is rare in high-income, tuberculosis (TB) low incidence countries, misdiagnoses occur as sufficient clinical experience is lacking. CASE PRESENTATION:We describe a fatal case of a patient with spinal TB, who was mistakenly irra...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-8-32
更新日期：2009-11-20 00:00:00
abstract：BACKGROUND:Multidrug resistant strains of Acinetobacter baumannii (MDR-AB) have emerged as alarming nosocomial pathogens among patients admitted to Intensive Care Unit and burned patients. The aim of this study was to determine the susceptibility of A. baumannii isolates, the carbapenems resistance patterns bla(OXA-23)...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-014-0038-0
更新日期：2014-09-25 00:00:00
abstract：BACKGROUND:Central line-associated bloodstream infections (CLABs) have long been associated with excess lengths of stay, increased hospital costs and mortality attributable to them. Different studies from developed countries have shown that practice bundles reduce the incidence of CLAB in intensive care units. However,...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,多中心研究
doi：10.1186/1476-0711-12-10
更新日期：2013-05-04 00:00:00
abstract：:Resistance to beta-lactam antibiotics in enteric Gram-negative bacilli may be difficult to detect using standard methods of either Kirby-Bauer disc diffusion (KBDD) or broth dilution for minimal inhibitory concentration (MIC). This difficulty is due to genetic differences in resistance determinants, differences in lev...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-3-13
更新日期：2004-07-15 00:00:00
abstract：:A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to organize the national recommendations for the management of zika virus infection. The focus of this document is the diagnosis, both clinical and laboratorial, and appropriate treatment of the diverse manifestations of thi...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-016-0172-y
更新日期：2016-09-29 00:00:00
abstract：BACKGROUND:Four medicinal plants (Chrozophora hierosolymitana Spreng, Chrysanthemum leucanthemum L., Ephedra gerardiana Wall. ex Stapf, and Quercus dilatata L.) used by indigenous healers to treat various infectious diseases were selected for the present study. The major objective of the present study was isolation and...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-11-11
更新日期：2012-05-03 00:00:00
abstract：BACKGROUND:Diarrhoeal diseases constitute a major public health problem, particularly in the developing world, where the rate of mortality and morbidity is very high. The purpose of this study was to conduct a 2 years and 3 months study in order to determine the prevalence of five enteropathogen diarrheogenic agents in...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-6-17
更新日期：2007-12-28 00:00:00
abstract：BACKGROUND:Urinary tract infections (UTI) can lead to poor maternal and perinatal outcomes. Investigating epidemiology of UTI and antibiotics sensitivity among pregnant women is fundamental for care-givers and health planners. METHODS:A cross sectional study has been conducted at Khartoum north teaching hospital Anten...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-2
更新日期：2011-01-18 00:00:00
abstract：BACKGROUND:Clinical microbiology laboratories have to accurately identify clinical microbes. However, some isolates are difficult to identify by the automated biochemical text platforms, which are called "difficult-to-identify" microbes in this study. Therefore, the ability of 16S ribosomal DNA (16S rDNA) and internal ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-1
更新日期：2014-01-03 00:00:00
abstract：BACKGROUND:Klebsiella pneumoniae is a public health concern because of its ability to develop multidrug resistance and hypervirulent genotypes, of those capsular types K1 and K2 cause community and nosocomial life-threatening infections. This study aimed to determine the antibiotic susceptibility patterns and genotypic...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-020-00349-z
更新日期：2020-03-31 00:00:00
abstract：INTRODUCTION:During clinical use, gastrointestinal endoscopes are grossly contaminated with patient's native flora. These endoscopes undergo reprocessing to prevent infectious transmission upon future use. Endoscopy-associated infections and outbreaks have been reported, with a recent focus on the transmission of multi...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-018-0289-2
更新日期：2018-10-10 00:00:00
abstract：:Stenotrophomonas maltophilia (S. maltophilia) has recently emerged as an important nosocomial pathogen. Treatment of invasive infections caused by this organism is difficult as the bacterium is frequently resistant to a wide range of commonly used antimicrobials. Trimethoprim-sulfamethoxazole (TMP - SXT) is recommende...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-5-23
更新日期：2006-09-18 00:00:00
abstract：BACKGROUND:This study aimed to evaluate in vitro susceptibility to ceftobiprole of clinical strains identified from prosthetic joint infections (PJIs) compared to that of the associations currently recommended for post-operative empirical antibiotic therapy (PEAT) (vancomycin with either cefepime, third-generation ceph...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-020-00351-5
更新日期：2020-03-21 00:00:00
abstract：BACKGROUND:In 2002 we investigated an outbreak comprising 231 patients in Norway, caused by Pseudomonas aeruginosa and linked to the use of contaminated mouth swabs called Dent-O-Sept. Here we describe the extent of contamination of the swabs, and identify critical points in the production process that made the contami...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-6-3
更新日期：2007-03-13 00:00:00
abstract：BACKGROUND:Diarrheal diseases continue to be the major cause of morbidity and mortality among children under 5 years. Salmonella and Shigella specious are the major enteric pathogen causing diarrhea among children worldwide. Examination of stool sample is the most sensitive method to diagnose diarrheal disease in child...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-018-0253-1
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Malaria and HIV/AIDS are the two most common infections in sub-Sahara Africa. There are hypotheses and study reports on the possible association between these two infections, hence the prevalence and outcome of their co-infection in an endemic population will be important in defining healthcare strategies. A...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-015-0064-6
更新日期：2015-03-07 00:00:00
abstract：BACKGROUND:Antibiotic resistance is a defense mechanism, harbored by pathogens to survive under unfavorable conditions. Among several antibiotic resistant microbial consortium, Staphylococcus aureus is one of the most havoc microorganisms. Staphylococcus aureus encodes a unique enzyme 6-hydroxymethyl-7,8-dihydropterin ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/s12941-018-0266-9
更新日期：2018-04-02 00:00:00
abstract：BACKGROUND:The aim of the present work was to evaluate the antibacterial effect of 3,4-DHPEA-EA (methyl-4-(2-(3,4-dihydroxyphenethoxy)-2-oxoethyl)-3-formyl-2-methyl-3,4-dihydro-2H-pyran-5-carboxylate), a derivate of oleuropein, against a range of Gram-positive bacteria, including ATCC strains, food and clinical isolate...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-13-24
更新日期：2014-07-01 00:00:00
abstract：:An 87 -year-old female who was undergoing peritoneal dialysis presented with peritonitis caused by Alcaligenes faecalis and Pantoea agglomerans in consecutive years. With the following report we discuss the importance of these unusual microorganisms in peritoneal dialysis patients. ...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-10-12
更新日期：2011-04-10 00:00:00
abstract：BACKGROUND:Mycetoma is a chronic mutilating disease of the skin and the underlying tissues caused by fungi or bacteria. Although recently included in the list of neglected tropical diseases by the World Health Organization, strategic control and preventive measures are yet to be outlined. Thus, it continues to pose hug...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-018-0287-4
更新日期：2018-08-10 00:00:00
abstract：:Ebola virus disease (EVD) is a potentially fatal haemorrhagic disease of humans. The last and most serious outbreak of Ebola virus (EBOV) started in December 2013 in West Africa and also affected other continents. Animals such as fruit bats and non-human primates are potential sources of EBOV. This review highlights t...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章,评审
doi：10.1186/s12941-015-0089-x
更新日期：2015-05-28 00:00:00
abstract：BACKGROUND:Accurate measurement of the incidence of diarrhoeagenic E. coli in patients with diarrhoea is hindered by the current methods of detection and varies from country to country. In order to improve the diagnosis of diarrhoeagenic E. coli (DEC), we developed a set of multiplex TaqMan real-time PCRs designed to d...
journal_title：Annals of clinical microbiology and antimicrobials
pub_type： 杂志文章
doi：10.1186/1476-0711-9-5
更新日期：2010-01-22 00:00:00
