Abstract:
:Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable reestablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de- and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Snaidero N,Schifferer M,Mezydlo A,Zalc B,Kerschensteiner M,Misgeld Tdoi
10.1038/s41467-020-18632-0subject
Has Abstractpub_date
2020-09-29 00:00:00pages
4901issue
1issn
2041-1723pii
10.1038/s41467-020-18632-0journal_volume
11pub_type
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