Myelin replacement triggered by single-cell demyelination in mouse cortex.

Abstract:

:Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable reestablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de- and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.

journal_name

Nat Commun

journal_title

Nature communications

authors

Snaidero N,Schifferer M,Mezydlo A,Zalc B,Kerschensteiner M,Misgeld T

doi

10.1038/s41467-020-18632-0

subject

Has Abstract

pub_date

2020-09-29 00:00:00

pages

4901

issue

1

issn

2041-1723

pii

10.1038/s41467-020-18632-0

journal_volume

11

pub_type

杂志文章
  • Mutualism increases diversity, stability, and function of multiplex networks that integrate pollinators into food webs.

    abstract::Ecosystems are composed of complex networks of many species interacting in different ways. While ecologists have long studied food webs of feeding interactions, recent studies increasingly focus on mutualistic networks including plants that exchange food for reproductive services provided by animals such as pollinator...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15688-w

    authors: Hale KRS,Valdovinos FS,Martinez ND

    更新日期:2020-05-01 00:00:00

  • High-performance reconstruction of microscopic force fields from Brownian trajectories.

    abstract::The accurate measurement of microscopic force fields is crucial in many branches of science and technology, from biophotonics and mechanobiology to microscopy and optomechanics. These forces are often probed by analysing their influence on the motion of Brownian particles. Here we introduce a powerful algorithm for mi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07437-x

    authors: Pérez García L,Donlucas Pérez J,Volpe G,V Arzola A,Volpe G

    更新日期:2018-12-04 00:00:00

  • Molecular determinants of nephron vascular specialization in the kidney.

    abstract::Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we employ high-throughput bulk and...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12872-5

    authors: Barry DM,McMillan EA,Kunar B,Lis R,Zhang T,Lu T,Daniel E,Yokoyama M,Gomez-Salinero JM,Sureshbabu A,Cleaver O,Di Lorenzo A,Choi ME,Xiang J,Redmond D,Rabbany SY,Muthukumar T,Rafii S

    更新日期:2019-12-13 00:00:00

  • MIS-11 duration key to disappearance of the Greenland ice sheet.

    abstract::Palaeo data suggest that Greenland must have been largely ice free during Marine Isotope Stage 11 (MIS-11). However, regional summer insolation anomalies were modest during this time compared to MIS-5e, when the Greenland ice sheet likely lost less volume. Thus it remains unclear how such conditions led to an almost c...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms16008

    authors: Robinson A,Alvarez-Solas J,Calov R,Ganopolski A,Montoya M

    更新日期:2017-07-06 00:00:00

  • Transformation from crystalline precursor to perovskite in PbCl2-derived MAPbI3.

    abstract::Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05937-4

    authors: Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

    更新日期:2018-08-27 00:00:00

  • Fibre-optic metadevice for all-optical signal modulation based on coherent absorption.

    abstract::Recently, coherent control of the optical response of thin films in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to all-optical image processing. Here, we show that integration of metamaterial and optical fibre technologies all...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02434-y

    authors: Xomalis A,Demirtzioglou I,Plum E,Jung Y,Nalla V,Lacava C,MacDonald KF,Petropoulos P,Richardson DJ,Zheludev NI

    更新日期:2018-01-12 00:00:00

  • Giant enhancement in vertical conductivity of stacked CVD graphene sheets by self-assembled molecular layers.

    abstract::Layer-by-layer-stacked chemical vapour deposition (CVD) graphene films find applications as transparent and conductive electrodes in solar cells, organic light-emitting diodes and touch panels. Common to lamellar-type systems with anisotropic electron delocalization, the plane-to-plane (vertical) conductivity in such ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6461

    authors: Liu Y,Yuan L,Yang M,Zheng Y,Li L,Gao L,Nerngchamnong N,Nai CT,Sangeeth CS,Feng YP,Nijhuis CA,Loh KP

    更新日期:2014-11-20 00:00:00

  • Manipulation of B-cell responses with histone deacetylase inhibitors.

    abstract::Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7838

    authors: Waibel M,Christiansen AJ,Hibbs ML,Shortt J,Jones SA,Simpson I,Light A,O'Donnell K,Morand EF,Tarlinton DM,Johnstone RW,Hawkins ED

    更新日期:2015-04-27 00:00:00

  • Potential climate engineering effectiveness and side effects during a high carbon dioxide-emission scenario.

    abstract::The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4304

    authors: Keller DP,Feng EY,Oschlies A

    更新日期:2014-02-25 00:00:00

  • Photoswitchable fatty acids enable optical control of TRPV1.

    abstract::Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8118

    authors: Frank JA,Moroni M,Moshourab R,Sumser M,Lewin GR,Trauner D

    更新日期:2015-05-22 00:00:00

  • Dual loss of human POLQ and LIG4 abolishes random integration.

    abstract::Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its mino...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms16112

    authors: Saito S,Maeda R,Adachi N

    更新日期:2017-07-11 00:00:00

  • Nanoscale geochemical and geomechanical characterization of organic matter in shale.

    abstract::Solid organic matter (OM) plays an essential role in the generation, migration, storage, and production of hydrocarbons from economically important shale rock formations. Electron microscopy images have documented spatial heterogeneity in the porosity of OM at nanoscale, and bulk spectroscopy measurements have documen...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-02254-0

    authors: Yang J,Hatcherian J,Hackley PC,Pomerantz AE

    更新日期:2017-12-19 00:00:00

  • Global patterns of the leaf economics spectrum in wetlands.

    abstract::The leaf economics spectrum (LES) describes consistent correlations among a variety of leaf traits that reflect a gradient from conservative to acquisitive plant strategies. So far, whether the LES holds in wetland plants at a global scale has been unclear. Using data on 365 wetland species from 151 studies, we find t...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18354-3

    authors: Pan Y,Cieraad E,Armstrong J,Armstrong W,Clarkson BR,Colmer TD,Pedersen O,Visser EJW,Voesenek LACJ,van Bodegom PM

    更新日期:2020-09-09 00:00:00

  • Regional boreal biodiversity peaks at intermediate human disturbance.

    abstract::The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2145

    authors: Mayor SJ,Cahill JF Jr,He F,Sólymos P,Boutin S

    更新日期:2012-01-01 00:00:00

  • Massive yet grossly underestimated global costs of invasive insects.

    abstract::Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms12986

    authors: Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

    更新日期:2016-10-04 00:00:00

  • Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates.

    abstract::Two-Photon Microscopy has become an invaluable tool for biological and medical research, providing high sensitivity, molecular specificity, inherent three-dimensional sub-cellular resolution and deep tissue penetration. In terms of imaging speeds, however, mechanical scanners still limit the acquisition rates to typic...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-15618-w

    authors: Karpf S,Riche CT,Di Carlo D,Goel A,Zeiger WA,Suresh A,Portera-Cailliau C,Jalali B

    更新日期:2020-04-28 00:00:00

  • Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence.

    abstract::Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01025-1

    authors: Yeung CT,Yim KH,Wong HY,Pal R,Lo WS,Yan SC,Yee-Man Wong M,Yufit D,Smiles DE,McCormick LJ,Teat SJ,Shuh DK,Wong WT,Law GL

    更新日期:2017-10-24 00:00:00

  • Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)-H bonds with alkynes.

    abstract::Transition metal-catalyzed enantioselective Sonogashira-type oxidative C(sp3)-C(sp) coupling of unactivated C(sp3)-H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C(sp3)-H bond functionalization and the inhibition of readily occurring ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-13705-1

    authors: Zhang ZH,Dong XY,Du XY,Gu QS,Li ZL,Liu XY

    更新日期:2019-12-12 00:00:00

  • Nanosecond electron pulses in the analytical electron microscopy of a fast irreversible chemical reaction.

    abstract::We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11669-w

    authors: Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

    更新日期:2019-08-13 00:00:00

  • Integrating geological archives and climate models for the mid-Pliocene warm period.

    abstract::The mid-Pliocene Warm Period (mPWP) offers an opportunity to understand a warmer-than-present world and assess the predictive ability of numerical climate models. Environmental reconstruction and climate modelling are crucial for understanding the mPWP, and the synergy of these two, often disparate, fields has proven ...

    journal_title:Nature communications

    pub_type: 杂志文章,评审

    doi:10.1038/ncomms10646

    authors: Haywood AM,Dowsett HJ,Dolan AM

    更新日期:2016-02-16 00:00:00

  • Selectively exciting quasi-normal modes in open disordered systems.

    abstract::Transmission through disordered samples can be controlled by illuminating a sample with waveforms corresponding to the eigenchannels of the transmission matrix (TM). But can the TM be exploited to selectively excite quasi-normal modes and so control the spatial profile and dwell time inside the medium? We show in micr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07180-3

    authors: Davy M,Genack AZ

    更新日期:2018-11-09 00:00:00

  • Resonant catalysis of thermally activated chemical reactions with vibrational polaritons.

    abstract::Interaction between light and matter results in new quantum states whose energetics can modify chemical kinetics. In the regime of ensemble vibrational strong coupling (VSC), a macroscopic number [Formula: see text] of molecular transitions couple to each resonant cavity mode, yielding two hybrid light-matter (polarit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12636-1

    authors: Campos-Gonzalez-Angulo JA,Ribeiro RF,Yuen-Zhou J

    更新日期:2019-10-15 00:00:00

  • Geographic population structure analysis of worldwide human populations infers their biogeographical origins.

    abstract::The search for a method that utilizes biological information to predict humans' place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an effort to achieve this goal but with limited success. While biogeographical algorithms using next-generation seq...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms4513

    authors: Elhaik E,Tatarinova T,Chebotarev D,Piras IS,Maria Calò C,De Montis A,Atzori M,Marini M,Tofanelli S,Francalacci P,Pagani L,Tyler-Smith C,Xue Y,Cucca F,Schurr TG,Gaieski JB,Melendez C,Vilar MG,Owings AC,Gómez R,Fuji

    更新日期:2014-04-29 00:00:00

  • Single-molecule study of oxidative enzymatic deconstruction of cellulose.

    abstract::LPMO (lytic polysaccharide monooxygenase) represents a unique paradigm of cellulosic biomass degradation by an oxidative mechanism. Understanding the role of LPMO in deconstructing crystalline cellulose is fundamental to the enzyme's biological function and will help to specify the use of LPMO in biorefinery applicati...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01028-y

    authors: Eibinger M,Sattelkow J,Ganner T,Plank H,Nidetzky B

    更新日期:2017-10-12 00:00:00

  • Radical cascade reaction of alkynes with N-fluoroarylsulfonimides and alcohols.

    abstract::Cascade reactions initiated by radical addition to alkynes are synthetically very attractive because they enable access to highly complex molecular skeletons in only few synthetic steps under usually mild conditions. Here we report a general radical cascade reaction of alkynes, N-fluoroarylsulfonimides and alcohols, e...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms8011

    authors: Zheng G,Li Y,Han J,Xiong T,Zhang Q

    更新日期:2015-04-22 00:00:00

  • SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.

    abstract::Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6108

    authors: Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

    更新日期:2014-10-30 00:00:00

  • A single NaK channel conformation is not enough for non-selective ion conduction.

    abstract::NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03179-y

    authors: Shi C,He Y,Hendriks K,de Groot BL,Cai X,Tian C,Lange A,Sun H

    更新日期:2018-02-19 00:00:00

  • Odour concentration-dependent olfactory preference change in C. elegans.

    abstract::The same odorant can induce attractive or repulsive responses depending on its concentration in various animals including humans. However, little is understood about the neuronal basis of this behavioural phenomenon. Here we show that Caenorhabditis elegans avoids high concentrations of odorants that are attractive at...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1750

    authors: Yoshida K,Hirotsu T,Tagawa T,Oda S,Wakabayashi T,Iino Y,Ishihara T

    更新日期:2012-03-13 00:00:00

  • Identity crisis in alchemical space drives the entropic colloidal glass transition.

    abstract::A universally accepted explanation for why liquids sometimes vitrify rather than crystallize remains hotly pursued, despite the ubiquity of glass in our everyday lives, the utilization of the glass transition in innumerable modern technologies, and nearly a century of theoretical and experimental investigation. Among ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07977-2

    authors: Teich EG,van Anders G,Glotzer SC

    更新日期:2019-01-08 00:00:00

  • The footprint of column collapse regimes on pyroclastic flow temperatures and plume heights.

    abstract::The gravitational collapse of eruption columns generates ground-hugging pyroclastic density currents (PDCs) with highly variable temperatures, high enough to be a threat for communities surrounding volcanoes. The reasons for such great temperature variability are debated in terms of eruptive versus transport and empla...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-10337-3

    authors: Trolese M,Cerminara M,Esposti Ongaro T,Giordano G

    更新日期:2019-06-06 00:00:00