当前位置： SCI文献检索 > INTERNATIONAL ORTHOPAEDICS期刊下所有文献 > High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture.

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture.

Abstract：

PURPOSE:The platelet-to-lymphocyte ratio (PLR) has been extensively studied in various diseases. However, the relationship between PLR and hip fracture remains unknown. The aim of this study was to evaluate whether PLR would be an independent prognostic factor in elderly hip fracture patients. METHODS:Between January 2014 and December 2018, a retrospective cohort study was conducted in a orthopaedic centre, China. A total of 460 hip fracture patients were included. PLR was calculated as the ratio of platelet to lymphocyte counts and divided into high PLR group (≥ 189) and low PLR group (< 189) by using the receiver operating characteristic (ROC) curve. The relationship between PLR and one year all-cause mortality rate was assessed by univariate and multivariate Cox proportional hazard models. Further subgroup analysis stratified by different clinical and biological characteristics was performed to make the results more accurate. RESULTS:After a median follow-up of 32.0 months (range, 12.0-75.4), 92 patients (mortality rate: 20.0%) died within one year. PLR was significantly higher in dead patients compared with alive patients (p < 0.05), and high PLR group also had a high mortality rate (32.21% vs. 14.15%, p < 0.001). After multivariate adjustment, high PLR remained an independent predictor for one year all-cause mortality (adjusted hazard ratio (HR) 1.56, 95% confidence interval (CI) 1.02-2.41, p = 0.041). Moreover, advanced age (HR 1.05, 95% CI 1.01-1.08), male (HR 1.62, 95% CI 1.06-2.45), CCI ≥ 2 (HR 2.83, 95% CI 1.64-4.89), conservative treatment (HR 5.94, 95% CI 3.71-9.73), low haemoglobin level (HR 1.02, 95% CI 1.01-1.04), and low albumin level (HR 1.07, 95% CI 1.02-1.13) were independent risk factors for survival. Furthermore, subgroup analysis results were consistent with the main findings in most stratified groups. CONCLUSION:This study highlights that high PLR (≥ 189) is associated with increased one year all-cause mortality in elderly hip fracture patients. As PLR is a simple indicator that can be calculated from the blood routine test, it can be easily performed in usual clinical practice.

journal_name

Int Orthop

journal_title

International orthopaedics

authors

Wang Z,Wang H,Yang L,Jiang W,Chen X,Liu Y

doi

10.1007/s00264-020-04833-1

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

13-21

issue

eissn

0341-2695

issn

1432-5195

pii

10.1007/s00264-020-04833-1

journal_volume

pub_type

杂志文章

在线工具

High platelet-to-lymphocyte ratio predicts poor survival of elderly patients with hip fracture.