Follow-up in the field of reproductive medicine: an ethical exploration.

Abstract:

RESEARCH QUESTION:What ethical implications, issues and concerns play a role in conducting follow-up studies of children born after assisted reproductive technologies (ART)? DESIGN:Literature study and relevant experiences of academic medical centres in Brussels, Belgium, and Maastricht, the Netherlands were used to identify and analyse the most pertinent ethical implications, issues and concerns. RESULTS:According to recommendations from the European Society of Human Reproduction and Embryology, follow-up (ideally long term) of children conceived through medically assisted reproduction (MAR) should be an integral part of introducing new ART. With potentially risky new ART on the horizon, these recommendations need to be taken more seriously. Apart from practical barriers, such as funding, challenges for follow-up include securing active involvement of families of children conceived through MAR, starting with parents of young children, and ideally involving consenting adolescents and adults during a large part of their lives, possibly even into the next generation. CONCLUSIONS:From an ethical viewpoint, the most pertinent issues include the proportionality of the inevitable burdens and risks for families of children conceived through MAR, and the implications of the principle of respect for autonomy. The proportionality requirement is most critical when it concerns incompetent children, who should not be included in research with more than minimal burdens and risks if there is no reasonable expectation of benefit for themselves. With respect for autonomy, we argue that, when seeking voluntary consent for participating in follow-up studies that meet the condition of proportionality, professionals may encourage members of families of children conceived through MAR to partake in follow-up research.

journal_name

Reprod Biomed Online

authors

Jans V,Dondorp W,Bonduelle M,de Die C,Mertes H,Pennings G,de Wert G

doi

10.1016/j.rbmo.2020.08.033

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1144-1150

issue

6

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(20)30466-1

journal_volume

41

pub_type

杂志文章
  • A prospective randomized controlled trial of Wallace and Rocket embryo transfer catheters.

    abstract::The aim of this study was to compare the efficacy of two embryo transfer catheters: Wallace and Rocket Embryon in an IVF programme of a tertiary referral university centre. A total of 308 patients undergoing embryo transfer were prospectively randomized to either a transfer with the Wallace catheter or a transfer with...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/s1472-6483(10)60243-x

    authors: El-Shawarby SA,Ravhon A,Skull J,Ellenbogen A,Trew G,Lavery S

    更新日期:2008-10-01 00:00:00

  • Effect of donor cell age on the efficiency of nuclear transfer in rabbits.

    abstract::The ability of rabbit fibroblasts of different ages to be reprogrammed following nuclear transfer (NT) to aged recipient oocytes was evaluated. The rate of NT blastocysts reconstructed with presumptive G1 stage morula cells or fetal fibroblasts was significantly higher (41.5% and 51.4%) than was those of cloned embryo...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)61912-8

    authors: Galat V,Lagutina I,Mezina M,Prokofiev MI,Zakhartchenko V

    更新日期:2002-01-01 00:00:00

  • Screening oocytes by polar body biopsy.

    abstract::Preimplantation genetic aneuploidy screening performed by polar body biopsy has become a frequently used method, especially as in several countries only preconceptional genetic diagnosis is allowed. To penetrate the zona pellucida, mechanical, chemical and laser-assisted techniques have been introduced. In this paper,...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)62023-8

    authors: Dawson A,Griesinger G,Diedrich K

    更新日期:2006-07-01 00:00:00

  • Artificial oocyte activation improves cycles with prospects of ICSI fertilization failure: a sibling oocyte control study.

    abstract:RESEARCH QUESTION:Does artificial oocyte activation improve clinical outcomes for patients at risk of intracytoplasmic sperm injection (ICSI) fertilization failure? DESIGN:In this study, sibling oocytes from patients with previous ICSI failure or severe teratozoospermia were divided equally into two groups, half for a...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2019.03.216

    authors: Li J,Zheng X,Lian Y,Li M,Lin S,Zhuang X,Chen L,Liu P,Qiao J

    更新日期:2019-08-01 00:00:00

  • Testicular tissue cryopreservation is the preferred method to preserve spermatogonial stem cells prior to transplantation.

    abstract:RESEARCH QUESTION:Which cryopreservation method better protects reproductive potential: the cryopreservation of a testicular cell suspension (TCS) or the cryopreservation of testicular tissue (TET)? DESIGN:Two cryopreservation strategies for spermatogonial stem cells (SSCs) were compared in a mouse model: cryopreserva...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2019.10.016

    authors: Onofre J,Kadam P,Baert Y,Goossens E

    更新日期:2020-02-01 00:00:00

  • New evidence of the presence of endometriosis in the human fetus.

    abstract::The aetiology of endometriosis, a gynaecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity, is still open to debate. Research has recently found evidence for endometriosis in human female fetuses at different gestational ages. This paper reports a new case...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2010.04.002

    authors: Signorile PG,Baldi F,Bussani R,D'Armiento M,De Falco M,Boccellino M,Quagliuolo L,Baldi A

    更新日期:2010-07-01 00:00:00

  • Live birth in women with multiple sclerosis receiving assisted reproduction.

    abstract:RESEARCH QUESTION:Multiple sclerosis is predominant in women during the childbearing years and, in case of problems with conceiving naturally, assisted reproductive technology (ART) becomes relevant. The efficacy of ART treatment in women with multiple sclerosis has not previously been studied. Our aim was to examine t...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2020.01.013

    authors: Jølving LR,Larsen MD,Fedder J,Nørgård BM

    更新日期:2020-05-01 00:00:00

  • Apoptosis in the human ovary.

    abstract::Programmed cell death or apoptosis is an essential component of human ovarian function and development. During early fetal life approximately 7 x 10(6) oocytes are formed in the human ovary. However, the number of oocytes is dramatically reduced already before birth through apoptotic cell death. In reproductive life, ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)62052-4

    authors: Vaskivuo TE,Tapanainen JS

    更新日期:2003-01-01 00:00:00

  • Fundamentals of cryobiology in reproductive medicine.

    abstract::The aim of this review will be to provide a basic understanding of the biophysical processes that accompany the application of cryopreservation in reproductive medicine. The ability to store cells in 'suspended animation' outside the body has become a keystone practice in the development of many modern clinical therap...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)61780-4

    authors: Fuller B,Paynter S

    更新日期:2004-12-01 00:00:00

  • Safety and efficacy of the minilaparotomy for myomectomy: a systematic review and meta-analysis of randomized and non-randomized controlled trials.

    abstract::Myomectomy is the most frequent reproductive surgery to preserve, improve fertility, or both. The present study was designed to assess the safety and efficacy of minilaparotomy for myomectomy through a systematic review of randomized and non-randomized controlled trials with a meta-analysis. All available studies comp...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.rbmo.2015.01.013

    authors: Palomba S,Fornaciari E,Falbo A,La Sala GB

    更新日期:2015-05-01 00:00:00

  • How common is polycystic ovary syndrome in recurrent miscarriage?

    abstract::The association between polycystic ovary syndrome (PCOS) and recurrent miscarriage (RM) has been long established, but the relative importance of this condition as a cause of RM is far from clear. Previous studies on the prevalence of PCOS in RM have been hampered by a lack of objective and universally accepted criter...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2009.06.003

    authors: Cocksedge KA,Saravelos SH,Metwally M,Li TC

    更新日期:2009-10-01 00:00:00

  • Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review.

    abstract::Gonadotrophin-releasing hormone (GnRH) antagonists suppress gonadotrophin secretion resulting in dramatic reduction in treatment cycle duration. Assuming comparable clinical outcomes, these benefits may justify changing the standard long GnRH agonist protocol to GnRH antagonist regimens. To evaluate the evidence, data...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)61059-0

    authors: Al-Inany HG,Abou-Setta AM,Aboulghar M

    更新日期:2007-05-01 00:00:00

  • Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

    abstract::The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a nega...

    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章

    doi:10.1016/j.rbmo.2016.02.004

    authors: Markoff A,Kurahashi H,Grandone E,Bogdanova N

    更新日期:2016-05-01 00:00:00

  • The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment.

    abstract::Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/j.rbmo.2013.06.014

    authors: Lewis SE,John Aitken R,Conner SJ,Iuliis GD,Evenson DP,Henkel R,Giwercman A,Gharagozloo P

    更新日期:2013-10-01 00:00:00

  • Failure mode and effects analysis of witnessing protocols for ensuring traceability during IVF.

    abstract::Traceability of cells during IVF is a fundamental aspect of treatment, and involves witnessing protocols. Failure mode and effects analysis (FMEA) is a method of identifying real or potential breakdowns in processes, and allows strategies to mitigate risks to be developed. To examine the risks associated with witnessi...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2015.06.018

    authors: Rienzi L,Bariani F,Dalla Zorza M,Romano S,Scarica C,Maggiulli R,Nanni Costa A,Ubaldi FM

    更新日期:2015-10-01 00:00:00

  • Multiple pregnancies after assisted reproduction--international comparison.

    abstract::The high incidence of multiple pregnancies after application of techniques for assisted reproduction is a phenomenon of major concern worldwide. High order multiples in particular have to be regarded as a serious adverse event. However, data show that in Europe, although the situation varies from country to country, m...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)62252-3

    authors: Felberbaum RE

    更新日期:2007-01-01 00:00:00

  • Circulatory metastin/kisspeptin-1 in polycystic ovary syndrome: a systematic review and meta-analysis with diagnostic test accuracy.

    abstract:RESEARCH QUESTION:A close association between Kisspeptin-1 (KISS-1) and reproductive physiology has been reported, but the results on circulatory KISS-1 are ambiguous in patients with polycystic ovary syndrome (PCOS). A systematic review and meta-analysis were conducted to evaluate the association between KISS-1 and PC...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.rbmo.2019.04.018

    authors: Varikasuvu SR,Prasad VS,Vamshika VC,Satyanarayana MV,Panga JR

    更新日期:2019-10-01 00:00:00

  • Prediction of pituitary down-regulation by evaluation of endometrial thickness in an IVF programme.

    abstract::The aim of this retrospective study was to determine whether pituitary down-regulation after gonadotrophin-releasing hormone analogue (GnRHa) administration can be accurately predicted by transvaginal ultrasonographic measurement of endometrial thickness in the presence of menstruation. All cycles of an IVF/intracytop...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)61109-1

    authors: Dogan MM,Uygur D,Alkan RN,Batioglu S,Mollamahmutoglu L

    更新日期:2004-05-01 00:00:00

  • Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF.

    abstract::This report aimed to examine the effects of atosiban on pregnancy outcome after IVF-embryo transfer. A prospective, randomized, placebo-controlled clinical study was performed. A total of 180 women undergoing intracytoplasmic sperm injection who had top-quality embryos were randomly allocated into treatment and contro...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.rbmo.2010.04.009

    authors: Moraloglu O,Tonguc E,Var T,Zeyrek T,Batioglu S

    更新日期:2010-09-01 00:00:00

  • Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

    abstract::The aneuploidy rates in expanded blastocysts biopsied on days 5 and 6 development were assessed in women undergoing IVF followed by array comparative genomic hybridization. This study included 1171 expanded blastocysts from 465 patients. Among the 465 patients, 215 and 141 underwent embryo biopsy on day 5 and day 6 (4...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2016.06.005

    authors: Piccolomini MM,Nicolielo M,Bonetti TC,Motta EL,Serafini PC,Alegretti JR

    更新日期:2016-09-01 00:00:00

  • Prolonged blastomere movement induced by the delay of pronuclear fading and first cell division adversely affects pregnancy outcomes after fresh embryo transfer on Day 2: a time-lapse study.

    abstract:RESEARCH QUESTION:What is the incidence, origin and clinical significance of blastomere movement after the first cell division in the human embryo? DESIGN:A total of 1096 embryos, cultured in the EmbryoScope+ ® time-lapse system and subjected to a single fresh cleaved embryo transfer, were retrospectively analysed. Ty...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2018.12.014

    authors: Ezoe K,Ohata K,Morita H,Ueno S,Miki T,Okimura T,Uchiyama K,Yabuuchi A,Kobayashi T,Montag M,Kato K

    更新日期:2019-05-01 00:00:00

  • Reproductive outcomes in recipients are not associated with oocyte donor body mass index up to 28 kg/m2: a cohort study of 2722 cycles.

    abstract::The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (L...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2017.07.019

    authors: Martínez F,Kava-Braverman A,Clúa E,Rodríguez I,Gaggiotti Marre S,Coroleu B,Barri PN

    更新日期:2017-12-01 00:00:00

  • Intended parents' motivations and information and support needs when seeking extraterritorial compensated surrogacy.

    abstract::Cross-border reproductive care (CBRC) is becoming increasingly common. Little is known about the motivations and information and support needs of people who cross borders to access surrogacy. This study aimed to explore: how those considering or undertaking extraterritorial surrogacy reach their decision; what other a...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2015.08.008

    authors: Hammarberg K,Stafford-Bell M,Everingham S

    更新日期:2015-11-01 00:00:00

  • History of oocyte cryopreservation.

    abstract::The potential advantages of being able to cryopreserve oocytes have been apparent for many decades. Technical difficulties associated with the unique properties of the mammalian oocyte initially retarded rapid development in this area but recent advances have overcome many of the problems. A stage has now been reached...

    journal_title:Reproductive biomedicine online

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.rbmo.2010.10.018

    authors: Gook DA

    更新日期:2011-09-01 00:00:00

  • Advanced oocyte cryopreservation will not undermine the practice of ethical egg sharing.

    abstract::The fear that the ethics and practice of egg sharing will be undermined by the growing success of oocyte cryopreservation is not based on published evidence. Separate contracts and directed counselling of donors and recipients as required by law in the UK provide protection against potential pitfalls with egg sharing....

    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章

    doi:10.1016/s1472-6483(10)60997-2

    authors: Ahuja KK,Simons EG

    更新日期:2006-03-01 00:00:00

  • Maternal serum markers in predicting successful outcome in expectant management of missed miscarriage.

    abstract::The aim of this study was to evaluate the use of biological serum markers, available routinely in most hospital clinical laboratories, in predicting successful outcomes of expectant management in women presenting with a missed miscarriage. This is a single centre observational prospective study over a 16-month period....

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2016.09.004

    authors: Memtsa M,Jauniaux E,Gulbis B,Nyrhinen NC,Jurkovic D

    更新日期:2017-01-01 00:00:00

  • A zygote is not an embryo: ethical and legal considerations.

    abstract::In spite of several past attempts at defining the point at which conception can be considered completed, resulting in the formation of an embryo, the existing definitions are still contradictory. In the absence of clear terminology, the application of laws aimed at the protection of early human life may have inadequat...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)62103-7

    authors: Tesarik J,Greco E

    更新日期:2004-07-01 00:00:00

  • Comparison of the psychological evaluation test and classical psychoanalysis in infertile women.

    abstract::This study aims to compare a psychological evaluation test to classical psychoanalysis in infertile women. Two hundred women were submitted to the Psychological Evaluation Test (PET). The sum of the scores for the responses ranged from 15 to 60 points, with scores >/=30 points being defined as 'psycho-emotional maladj...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)60492-0

    authors: Franco JG Jr,Silva PG,Achê RS,Baruffi RR,Mauri AL,Petersen CG,Felipe V,Vagnini L,Oliveira JB

    更新日期:2004-01-01 00:00:00

  • Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique.

    abstract::This paper presents the Danish 10-year experience (1999-2009) with cryopreservation (n=386) and autotransplantation of ovarian tissue (n=18). Before applying the technique to humans, the method was thoroughly tested and validated. The cryoprotectant solution was chosen after histological evaluation of mouse and human ...

    journal_title:Reproductive biomedicine online

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.rbmo.2010.10.015

    authors: Rosendahl M,Schmidt KT,Ernst E,Rasmussen PE,Loft A,Byskov AG,Andersen AN,Andersen CY

    更新日期:2011-02-01 00:00:00

  • Fatty acids of follicular fluid phospholipids and triglycerides display distinct association with IVF outcomes.

    abstract:RESEARCH QUESTION:Are triglyceride fatty acids in the follicular fluid associated with either follicular fluid phospholipid fatty acids or IVF outcomes and, if so, how are they associated? DESIGN:In a prospective cross-sectional study, 70 women undergoing intracytoplasmic sperm injection were recruited. Follicular flu...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2020.09.024

    authors: Zarezadeh R,Nouri M,Hamdi K,Shaaker M,Mehdizadeh A,Darabia M

    更新日期:2020-10-04 00:00:00