Abstract：
:Patients with acute lymphoblastic leukemia (ALL) are characterized by an unfavorable outcome in the majority of adult cases. Several clinical trials have confirmed the usefulness of a pediatric-type therapy applied to adult patients. Adults present with higher risk features at diagnosis that predispose them to chemotherapy resistance and disease relapse after an initial achievement of complete remission. The recent introduction of novel immune-targeted therapies, including monoclonal antibodies (MoAbs) targeting B cell-associated antigens such as CD19 (blinatumumab) and CD22 (inotuzumab), tyrosine kinase inhibitors targeting BCR-ABL1 tyrosine kinase, bispecific antibodies and chimeric antigen receptor T- cell therapy (CAR-T), circumvent B-ALL cell chemo-refractoriness through novel mechanisms of action, potentially eradicating minimal residual disease (MRD) and enabling more patients to receive allogeneic hematopoietic stem cell transplantation and to achieve a better clinical outcome.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Lanza F,Maffini E,Saraceni F,Massari E,Rondoni M,Daghia G,Olivieri A,Cerchione C,Martinelli Gdoi
10.23736/S0026-4806.20.07031-7subject
Has Abstractpub_date
2020-10-01 00:00:00pages
478-490issue
5eissn
0026-4806issn
1827-1669pii
S0026-4806.20.07031-7journal_volume
111pub_type
杂志文章,评审相关文献
MINERVA MEDICA文献大全abstract：:A case of myelofibrosis developing in a peripheral leukaemia-type situation after splenectomy is presented. An examination of the hypotheses on the pathogenesis of myeloid metaplasia during myelofibrosis lead to the proposition that it may be caused by the "seeding" of medullary precursors in the spleen. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1983-10-13 00:00:00
abstract：:Determination of serum bile acids has long been regarded as the most sensitive indicator of liver function. An assessment was made of the clinical applicability of RIA evaluation of two of these acids, cholylglycine (CG) and sulpholithochocholyglycine (SLGG), on an empty stomach and 2hr after a cholecystokinetic meal ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-01-28 00:00:00
abstract：AIM:Authors performed a Laboratory assessment for thrombophilia risk factors in a group of patients with previous deep venous thrombosis. METHODS:123 consecutive patients were considered. The following parameters were investigated by using commercially available methods: PT, aPTT, TT, Fibrinogen, D-Dimer, Anti thrombi...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:The double-blind, between-patient experimental technique was employed to investigate the anti-inflammatory, antalgic and myorelaxant activity of a new synthetic compound, parsalmide. 30 patients suffering from arthrosic and inflammatory arthropathies in various sites and in newly acute phase, were treated with the sub...
journal_title：Minerva medica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1976-10-31 00:00:00
abstract：INTRODUCTION:The aim of this study was to determine the role of Prognostic Nutritional Index in predicting gastric cancer. EVIDENCE ACQUISITION:Studies were searched in PubMed, EMBASE and ISI Web of Science. The hazard ratios and 95% confidence interval for survival estimate were extracted from the articles and the po...
journal_title：Minerva medica
pub_type： 杂志文章,meta分析
doi：
更新日期：2016-10-01 00:00:00
abstract：:Haemodynamic balance was assessed in relation to platelet-vessel homeostasis in the microcirculation in a group of 15 migraine sufferers and 15 healthy subjects. The results support the hypothesis of a relationship between the typical recurrence of migraine attacks and the chronobiological performance of the haemodyna...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-07-31 00:00:00
abstract：:The short-term (30 days) effects of lithium carbonate on ADH secretion, urinary enzyme secretion (specific markers of tubular damage), fractional excretion of sodium, calcaemia, calciuria and fractional reabsorption of phosphate, plasma and urinary Ca, urea and creatinine clearance were assessed in 15 female patients ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-02-28 00:00:00
abstract：:A 48-year-old female with a history of accentuated dyspnea, pleural thickening in anteromedial portion with left patchy parenchymal shadowing invading adjoining parasternal structure of the rib cage, presented 13 months later marked superclavicular, anterior mediastinic and parahilar left lymphadenopathy. Open surgica...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：:12 patients with normal QRS either in basal condition or during atrial pacing, undergone on single premature atrial stimulation, showed several types of intraventricular aberrancies. These have been revalued with atrial premature stimulation introduced over a progressively increasing frequency of fixed atrial stimulat...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1978-03-24 00:00:00
abstract：:The authors notice a prevalence of P. falciparum in eight observed cases of imported malaria and confirm the increasing polychemioresistance of plasmodium and its prophylactic and therapeutic problems. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:The prevalence of coronary artery disease is lower in women than in men. Ovarian estrogen is believed to decrease the risk of coronary heart disease. Today, there is an increasing demand for estrogen replacement not only for amelioration of menopausal subjective symptoms but also for the prophylactic action of estroge...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:The efficacy and tolerability of a new macrolide, Myocamycine, were assessed in the anti-infectious prophylaxis of lacerations and contusions and in the treatment of already infected wounds or phlegmons. A total of 175 patients were treated. Side effects induced the suspension of treatment in 8% of cases while the dru...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1987-11-15 00:00:00
abstract：:The results of preliminary research designed to prepare a method for using mouth measurements to identify alveolar air trapping phenomena which cannot be detected by normal techniques are reported. With a present rapid thermoconductivity CO2/He analyser, it was shown that even after the completion of a standard He was...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1977-03-31 00:00:00
abstract：:103 patient suffering from thyroid solitary nodule have been examined with gray-scale ultrasonography. 79 patients have been histologically confirmed. Research has been done with multi-transducer computerized water-bath equipment ( OCTOSON ). The results are discussed and a classification of the thyroid solitary nodul...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-05-12 00:00:00
abstract：:Atherosclerosis risk factor, 8,5% two, 2,7% three and 0,6% four.rs have been investigated in 194 males and 135 female, 25 years old. Elevated lipids were found in 7,3% of the sample; "labile" and stable hypertension in 2,7%; diabetes mellitus in 2,7% and overweight in 19%. 19% of the subjects smoked more than 20 cigar...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
abstract：:Twenty-three patients with orthopedic and traumatic disorders, mostly hospitalized, were treated with proglumetacin, 450 mg/day, during 5-45 days. Proglumetacin resulted to be a good analgesic and anti-inflammatory drug. Tolerance was good or excellent in all patients but one. Proglumetacin appears to be drug particul...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1983-06-23 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate, by Stress-Exercise Electrocardiography (SE), the presence of Coronary Artery Disease (CAD) in patients with asymptomatic or symptomatic carotid stenosis, who had no history of myocardial ischemia. MATERIALS, METHODS AND RESULTS:133 patients with significant carotid...
journal_title：Minerva medica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The action of alpha-mercaptopropionylglycine has been studied in 27 subjects occupationally exposed to lead. In addition to improved efficiency of liver function, the results show a tendency to normalization of the various porphyrinic metabolism parameters considered. A significant increase was observed in erythrocyte...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1979-09-26 00:00:00
abstract：BACKGROUND:To study the effect of melatonin on myocardial injury of septic rats through regulating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. METHODS:Healthy rats were selected as the samples and divided into blank group, sepsis group and sepsis + melatonin gr...
journal_title：Minerva medica
pub_type： 杂志文章
doi：10.23736/S0026-4806.20.06626-4
更新日期：2020-07-17 00:00:00
abstract：:Personal experience with acute enzymatic pancreatitis in 113 cases observed, over 11 years, at the Santa Croce Hospital Surgical Division is described. Only 58 cases (51,3%) were submitted to surgery and the remaining 55 cases (48,7%) were treated with medical therapy. A mortality of 16,8% was observed. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1977-05-05 00:00:00
abstract：:Personal clinical experience in 36 psychiatric patients with true or masqued depression, receiving a combined treatment of acupuncture (in traditional and auricolar suprarenalic points), "vital" drugs (DPA 300-900 mg/die; l-glutamine 250-500 mg/die) and psycho-drugs (amitryptiline 50 mg/die; clomipramine 10-30 mg/die;...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1977-07-07 00:00:00
abstract：:The value of serum ferritin assays in the diagnosis and staging of non-microcytoma bronchial cancer is assessed. It is pointed out that the marker is only minimally specific and sensitive in the diagnostic phase as well as being only slightly indicative in the staging of NSCLC. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-12-15 00:00:00
abstract：:Description of a clinical case diagnosed in the first hours of life in apparently well newborn. Diagnostic suspicion by palpation and transillumination. Absence of any subjective sign. Inspective symptom the light scrotal swelling. The neonate received an immediate surgical exploration with subsequent orchiectomy. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Electroacupuncture was used in the treatment of 50 cases of tropic ulcer of the lower extremities, including 34 following phlebitis, by stimulation with a Roccia VTM apparatus at voltages and frequencies up to the patient's tolerance threshold. The needles stimulation was maintained for a maximum of 7 hr. A cure was o...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1980-12-22 00:00:00
abstract：:Investigation of the abdomen by ultrasounds must now be included among routine tools in abdominal diseases. All abdominal organs, with the exception of the intestine with its gas content, are open to investigation with this technique which combines harmlessness and rapidity with its unique possibility of making differ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-06-16 00:00:00
abstract：BACKGROUND:Anthracyclines combined with paclitaxel are one of the most active schedules in patients with advanced breast cancer: response rates range from 40 to 80%, considering all metastatic sites (visceral and soft tissues). We performed a non-randomized phase II trial with anthracyclines/paclitaxel combination to e...
journal_title：Minerva medica
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:Despite significant risk reduction with statin therapy, there remains a residual cardiovascular risk. It has been seen that aggressive statin therapy in high risk patients may not lower the low-density lipoprotein cholesterol to goal in up to 40% of patients. Niacin is a potent high-density lipoprotein cholesterol-rai...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4806.18.05826-3
更新日期：2019-02-01 00:00:00
abstract：:A rare complication of calculous cholecystitis (calculous that had migrated from the gallbladder and held in a circumscribed peritoneal sac with no fistula between this and the gallbladder) was observed in a woman who had been suffering from dropsy of the gallbladder with calculi for some 13 years. The most recent lit...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-04-28 00:00:00
abstract：: ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：10.23736/S0026-4806.19.06147-0
更新日期：2019-10-01 00:00:00
abstract：: ...
journal_title：Minerva medica
pub_type： 信件
doi：10.23736/S0026-4806.19.05976-7
更新日期：2019-10-01 00:00:00
