Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review.

Abstract:

BACKGROUND:Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising small-vessel vasculitis, with a relapsing and remitting course. Like many autoimmune diseases, the exact aetiology of AAV, and the factors that influence relapse are unknown. Evidence suggests a complex interaction of polygenic genetic susceptibility, epigenetic influences and environmental triggers. This systematic mapping review focuses on the environmental risk factors associated with AAV. The aim was to identify gaps in the literature, thus informing further research. METHODS:Articles that examined any environmental risk factor in AAV disease activity (new onset disease or relapse) were included. Studies had to make explicit reference to AAV, which includes the 3 clinico-pathological phenotypes (GPA, MPA and EGPA), rather than isolated ANCA-positivity. All articles identified were English-language, full manuscripts involving adult humans (>16 years). There was no restriction on publication date and all study designs, except single case reports, were included. The systematic search was performed on 9th December 2019, using the following databases: EMBASE, Medline (Ovid), Cochrane Library, CINAHL and Web of Science. RESULTS:The search yielded a total of 2375 articles. 307 duplicates were removed, resulting in the title and abstract of 2068 articles for screening. Of these, 1809 were excluded. Thus, 259 remained for full-text review, of which 181 were excluded. 78 articles were included in this review. The most notable findings support the role of various pollutants - primarily silica and other environmental antigens released during natural disasters and through farming. Assorted geoepidemiological triggers were also identified including seasonality and latitude-dependent factors such as UV radiation. Finally, infection was tightly associated, but the exact microorganism(s) is not clear - Staphylococcus aureus is the most presently convincing. CONCLUSION:The precise aetiology of AAV has yet to be elucidated. It is likely that different triggers, and the degree to which they influence disease activity, vary by subgroup (e.g. ANCA subtype, geographic region). There is a need for more interoperable disease registries to facilitate international collaboration and hence large-scale epidemiological studies, with novel analytical techniques.

journal_name

Autoimmun Rev

journal_title

Autoimmunity reviews

authors

Scott J,Hartnett J,Mockler D,Little MA

doi

10.1016/j.autrev.2020.102660

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

102660

issue

11

eissn

1568-9972

issn

1873-0183

pii

S1568-9972(20)30235-4

journal_volume

19

pub_type

杂志文章
  • Cellular players in angiogenesis during the course of systemic sclerosis.

    abstract::Vascular endothelial injury in Systemic Sclerosis (SSc) leads to pathological changes in the blood vessels that adversely impact the physiology of many organs, resulting in chronic tissue ischemia. The response to hypoxia induces complex cellular and molecular mechanisms in the attempt to recover endothelial cell func...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.04.016

    authors: Cipriani P,Marrelli A,Liakouli V,Di Benedetto P,Giacomelli R

    更新日期:2011-08-01 00:00:00

  • Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients.

    abstract:OBJECTIVE:Low dose (10-25 mg/week) methotrexate is widely used for the management of systemic inflammatory diseases, and is considered to be relatively safe. Toxicity due to low dose MTX has been reported but is poorly characterized. We describe the clinical features, risk factors, and outcomes of low dose MTX toxicity...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.08.027

    authors: Kivity S,Zafrir Y,Loebstein R,Pauzner R,Mouallem M,Mayan H

    更新日期:2014-11-01 00:00:00

  • Role of MHC Class II genes in the pathogenesis of pemphigoid.

    abstract::Pemphigoid (Pg) is an autoimmune subepidermal blistering disease that affects the elderly population. The phenotype can be Bullous Pemphigoid (BP), which primarily involves the skin, or Mucous Membrane Pemphigoid (MMP), which primarily involves mucus membranes. Ocular Cicatricial Pemphigoid (OCP) and Oral Pemphigoid (...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.07.002

    authors: Zakka LR,Reche P,Ahmed AR

    更新日期:2011-11-01 00:00:00

  • Adrenal insufficiency in systematic lupus erythematosus (SLE) and antiphospholipid syndrome (APS): A systematic review.

    abstract:BACKGROUND:Adrenal insufficiency (AI) is associated with high morbidity and mortality. The aim of this systematic review was to enhance diagnostic approaches and summarize therapeutic strategies in the management of AI in patients with systematic lupus erythematosus (SLE) or antiphospholipid syndrome (APS). METHODS:A ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2018.06.014

    authors: Lee KH,Lee H,Lee CH,Kim JY,Kim JM,Kim SS,Jeong S,Hwang IS,Kim N,Kim NE,Shin S,Shin D,Song JS,Shin DH,Kim JD,Kim J,Lee YS,Kang H,Kim DH,Moon SH,Rho WS,Lee JY,Kronbichler A,Shin JI

    更新日期:2019-01-01 00:00:00

  • Insights into IL-37, the role in autoimmune diseases.

    abstract::Autoimmune diseases are characterized by the impaired function and the destruction of tissues that are caused by an immune response in which aberrant antibodies are generated and attack the body's own cells and tissues. Interleukin (IL) -37, a new member of the IL-1 family, broadly reduces innate inflammation as well ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2015.08.006

    authors: Xu WD,Zhao Y,Liu Y

    更新日期:2015-12-01 00:00:00

  • The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility.

    abstract::Type 1 diabetes (T1D) and the autoimmune thyroid diseases (AITD) are the most common autoimmune endocrine diseases. Both are organ-specific T-cell mediated diseases. Abundant epidemiological data support a strong genetic basis for both T1D and AITD. Furthermore, both diseases commonly occur in the same individuals and...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-9972(03)00080-6

    authors: Levin L,Tomer Y

    更新日期:2003-10-01 00:00:00

  • Rett syndrome: An autoimmune disease?

    abstract::Rett syndrome (RTT) is a devastating neurodevelopmental disease, previously included into the autistic spectrum disorders, affecting almost exclusively females (frequency 1:10,000). RTT leads to intellective deficit, purposeful hands use loss and late major motor impairment besides featuring breathing disorders, epile...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2016.01.011

    authors: De Felice C,Leoncini S,Signorini C,Cortelazzo A,Rovero P,Durand T,Ciccoli L,Papini AM,Hayek J

    更新日期:2016-04-01 00:00:00

  • Juvenile idiopathic arthritis.

    abstract::One of the most enigmatic problems in rheumatology has been juvenile idiopathic arthritis (JIA). Firstly, the classification has often depended on clinical features that have variations between patients. Secondly, there are different classification schemes in usage and there are few objective serologic tests that help...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2005.09.011

    authors: Borchers AT,Selmi C,Cheema G,Keen CL,Shoenfeld Y,Gershwin ME

    更新日期:2006-04-01 00:00:00

  • Epidemiological and ethical aspects of multiplex autoantibody testing.

    abstract::Arrays are one of the technologies able to detect autoantibodies by measuring simultaneously many thousands of markers from a unique biological sample. The main purpose of a diagnostic test is making an early and accurate diagnosis. From a statistical point of view, multiple testing increases the probability of false ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.01.008

    authors: Bidoli E,Villalta D,Ethical Committee of Pordenone Hospital, Italy.,Battistin M,Bidoli E,Cammarota A,Ciccone M,Fedato R,Lodi B,Marchesini F,Molaro G,Ostardo E,Rellini G,Sartori R,Schinella D

    更新日期:2007-06-01 00:00:00

  • Rituximab treatment for IgA vasculitis: A systematic review.

    abstract:BACKGROUND:Immunoglobulin A vasculitis (IgAV) is a systemic small vessel vasculitis for which treatment of severe cases is usually based on glucocorticoids and other conventional immunosuppressive drugs. The role of rituximab for resistant or refractory cases has been explored in isolated case reports and small series....

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2020.102490

    authors: Hernández-Rodríguez J,Carbonell C,Mirón-Canelo JA,Diez-Ruiz S,Marcos M,Chamorro AJ

    更新日期:2020-04-01 00:00:00

  • Treatment of Raynaud's phenomenon.

    abstract::Raynaud's phenomenon is an episodic vasospasm of the peripheral arteries, causing pallor followed by cyanosis and redness with pain and sometimes paraesthesia, and, rarely, ulceration of the fingers and toes. Primary or idiopathic Raynaud's phenomenon (Raynaud's disease) occurs without an underlying disease. Secondary...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2008.07.002

    authors: García-Carrasco M,Jiménez-Hernández M,Escárcega RO,Mendoza-Pinto C,Pardo-Santos R,Levy R,Maldonado CG,Chávez GP,Cervera R

    更新日期:2008-10-01 00:00:00

  • The effect of non-TNF-targeted biologics and small molecules on insulin resistance in inflammatory arthritis.

    abstract::Inflammatory arthritides are chronic diseases characterised by an increase in cardiovascular risk, largely attributable to the synergy between high-grade systemic inflammation and an elevated prevalence of traditional cardiovascular risk factors. Amongst the latter, insulin resistance and type 2 diabetes (T2D) play a ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2017.11.030

    authors: Ursini F,Russo E,Ruscitti P,Giacomelli R,De Sarro G

    更新日期:2018-04-01 00:00:00

  • Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders.

    abstract::Parkinson's disease, Alzheimer's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated in the down-stream events following deposition of misfolde...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2008.04.010

    authors: Neff F,Wei X,Nölker C,Bacher M,Du Y,Dodel R

    更新日期:2008-06-01 00:00:00

  • Anti-neuronal antibodies in patients with HCV-related mixed cryoglobulinemia.

    abstract::Mixed cryoglobulinemia (MC) is an immunological disorder characterized by immune-complex-mediated systemic vasculitis involving small vessels, which may present with renal, cutaneous, rheumatologic, and/or neurological manifestations. Until recently, the possible appearance of anti-neuronal autoantibodies in periphera...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2008.07.027

    authors: Alpa M,Ferrero B,Cavallo R,Naretto C,Menegatti E,Di Simone D,Napoli F,La Grotta R,Rossi D,Baldovino S,Sena LM,Roccatello D

    更新日期:2008-10-01 00:00:00

  • The role of nailfold capillaroscopy in the assessment of internal organ involvement in systemic sclerosis: A critical review.

    abstract::Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the disease. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature, aiding in distinguishing diff...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2017.05.019

    authors: Soulaidopoulos S,Triantafyllidou E,Garyfallos A,Kitas GD,Dimitroulas T

    更新日期:2017-08-01 00:00:00

  • Adaptive immune regulation in autoimmune diabetes.

    abstract::Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2015.11.008

    authors: Ferretti C,La Cava A

    更新日期:2016-03-01 00:00:00

  • Clinical and genetic aspects of Blau syndrome: a 25-year follow-up of one family and a literature review.

    abstract::Blau syndrome (BS) is a rare familial disease transmitted as an autosomal dominant trait, characterized by arthritis, uveitis, skin rash and granulomatous inflammation. Until now BS has been observed in 136 persons belonging to 28 families as well as in 4 sporadic cases. The gene responsible for BS has recently been i...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2008.07.034

    authors: Punzi L,Furlan A,Podswiadek M,Gava A,Valente M,De Marchi M,Peserico A

    更新日期:2009-01-01 00:00:00

  • Safety and efficacy of oral direct inhibitors of thrombin and factor Xa in antiphospholipid syndrome.

    abstract:BACKGROUND:Long-term anticoagulation is recommended in antiphospholipid syndrome with thrombosis in order to prevent recurrences. While the current mainstay relies on vitamin K antagonists, their long-term maintenance may remain challenging. OBJECTIVES:To report on the safety and the efficacy of oral direct inhibitors...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2015.03.007

    authors: Noel N,Dutasta F,Costedoat-Chalumeau N,Bienvenu B,Mariette X,Geffray L,Sene D,Chaidi RB,Michot JM,Fain O,Darnige L,Ankri A,Cacoub P,Piette JC,Saadoun D

    更新日期:2015-08-01 00:00:00

  • Integrins: a flexible platform for endothelial vascular tyrosine kinase receptors.

    abstract::Compared to lower metazoans, vertebrates built up an exclusively new set of adhesion-related genes involved in the tissue development and in their functions. They include a large variety of extracellular matrix proteins and their heterodimeric integrin adhesive receptors. Integrins control the adhesive state of the ce...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.03.007

    authors: Napione L,Cascone I,Mitola S,Serini G,Bussolino F

    更新日期:2007-11-01 00:00:00

  • Catastrophic antiphospholipid (Asherson's) syndrome and genetic thrombophilic disorders in obstetrics.

    abstract::Catastrophic antiphospholipid syndrome (CAPS) (Asherson's Syndrome), is a life-threatening condition characterized by a rapidly progressive thromboses resulting in a multiorgan dysfunction syndrome (MODS), evidence of systemic inflammatory response syndrome (SIRS) in the presence of antiphospholipid antibodies. CAPS d...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2006.06.011

    authors: Makatsariya A,Asherson RA,Bitsadze V,Baimuradova S,Akinshina S

    更新日期:2006-12-01 00:00:00

  • Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues.

    abstract::Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors. It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2018.01.004

    authors: Stagi S,Rigante D

    更新日期:2018-03-01 00:00:00

  • Human FoxP3+ regulatory T cells in systemic autoimmune diseases.

    abstract::Since the characterization of CD4(+)CD25(+) regulatory T (Treg) cells in mice, significant progress has been made in the definitions of the phenotype and the function of human Treg cells in health and in pathological conditions. Recent advances in the field leading to a better molecular definition of Treg subsets in h...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2011.05.004

    authors: Miyara M,Gorochov G,Ehrenstein M,Musset L,Sakaguchi S,Amoura Z

    更新日期:2011-10-01 00:00:00

  • T cell immunity in autoimmune hepatitis.

    abstract::T cells play a central role in the immunopathogenesis of AIH. Until recently CD4+ T cells were thought to be critical for disease development, increasing evidence has shown that CD8+ T and gammadelta T cells also play a significant role. The predisposition of certain HLA genotypes to AIH as well as the clonal expansio...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2005.01.005

    authors: Ichiki Y,Aoki CA,Bowlus CL,Shimoda S,Ishibashi H,Gershwin ME

    更新日期:2005-06-01 00:00:00

  • Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review.

    abstract::Autoantibodies are a hallmark in the diagnosis of many systemic autoimmune rheumatic diseases (SARD) including idiopathic inflammatory myopathies (IIM). Based on their specificity, autoantibodies in IIM are grouped into myositis specific (MSA) and myositis associated autoantibodies (MAA). Among the MSA, autoantibodies...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.01.022

    authors: Mahler M,Miller FW,Fritzler MJ

    更新日期:2014-04-01 00:00:00

  • Hyperhomocysteinemia, inflammation and autoimmunity.

    abstract::Hyperhomocysteinemia is independently associated with the development of coronary, cerebral and peripheral vascular disease and deep-vein thrombosis in the general population. The evidence that cardiovascular involvement is particularly frequent and advanced in patients affected with several autoimmune diseases (AD), ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2007.03.008

    authors: Lazzerini PE,Capecchi PL,Selvi E,Lorenzini S,Bisogno S,Galeazzi M,Laghi Pasini F

    更新日期:2007-08-01 00:00:00

  • Factors influencing polyautoimmunity in systemic lupus erythematosus.

    abstract:OBJECTIVE:Since characterization of the extent to which particular combinations of autoimmune diseases (ADs) occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms, polyautoimmunity (i.e., ADs co-occurring within patients) in systemic lupus erythematosus (SL...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章

    doi:10.1016/j.autrev.2009.10.001

    authors: Rojas-Villarraga A,Toro CE,Espinosa G,Rodríguez-Velosa Y,Duarte-Rey C,Mantilla RD,Iglesias-Gamarra A,Cervera R,Anaya JM

    更新日期:2010-02-01 00:00:00

  • Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: results from the French nationwide CryoVas survey.

    abstract:OBJECTIVE:Although in most patients induction therapy leads to complete or partial remission, relapses in patients with non-infectious mixed cryoglobulinemia vasculitis (CryoVas) remain a major problem. We aimed to identify predictors of early relapses occurring within the first 12months of treatment in such patients. ...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2013.11.006

    authors: Terrier B,Marie I,Launay D,Lacraz A,Belenotti P,de Saint-Martin L,Quemeneur T,Huart A,Bonnet F,Le Guenno G,Kahn JE,Hinschberger O,Rullier P,Diot E,Lazaro E,Bridoux F,Zénone T,Carrat F,Hermine O,Léger JM,Mariette X

    更新日期:2014-06-01 00:00:00

  • The hereditary autoinflammatory disorders uncovered.

    abstract::There is a thriving interest in the field of hereditary autoinflammatory disorders (HAID), a gamut of heterogeneous conditions deriving from an aberrant orchestration of innate immunity, unified by the common feature of seemingly unprovoked inflammation, which might be systemic or occur in localized niches of the orga...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.08.001

    authors: Rigante D,Vitale A,Lucherini OM,Cantarini L

    更新日期:2014-09-01 00:00:00

  • Autoantibody-mediated atherosclerosis.

    abstract::Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by beta2-GPI and anti-beta2-GPI autoantibodies. Ligands specific for beta2-GPI derived from oxLDL have be...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-9972(02)00084-8

    authors: Matsuura E,Kobayashi K,Koike T,Shoenfeld Y

    更新日期:2002-12-01 00:00:00

  • Autoimmune thyroid disorders.

    abstract::Autoimmune thyroid diseases (AITD) result from a dysregulation of the immune system leading to an immune attack on the thyroid. AITD are T cell-mediated organ-specific autoimmune disorders. The prevalence of AITD is estimated to be 5%; however, the prevalence of antithyroid antibodies may be even higher. The AITD comp...

    journal_title:Autoimmunity reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.autrev.2014.10.016

    authors: Antonelli A,Ferrari SM,Corrado A,Di Domenicantonio A,Fallahi P

    更新日期:2015-02-01 00:00:00