The effect of antivirals on COVID-19: a systematic review.

abstract：:Ceftobiprole is among the first of a new generation of cephalosporins with activity against aerobic Gram-negative bacilli, which extends to cefepime-sensitive Pseudomonas aeruginosa, and activity against Gram-positive organisms, which includes methicillin-resistant Staphylococcus aureus. Ceftobiprole is currently unde...

journal_title：Expert review of anti-infective therapy

authors： Schirmer PL,Deresinski SC

更新日期：2009-09-01 00:00:00

abstract：:Sertaconazole is an imidazole-type antifungal agent that has shown considerable in vitro activity against pathogenic fungi. Various studies carried out in animal models, clinical and toxicologic trials have confirmed the value of sertaconazole in the topical treatment of superficial mycoses in dermatology and gynecolo...

journal_title：Expert review of anti-infective therapy

authors： Carrillo-Muñoz AJ,Giusiano G,Ezkurra PA,Quindós G

更新日期：2005-06-01 00:00:00

abstract：:Tuberculosis continues to be a major health problem worldwide, affecting millions of people each year. Accurate and rapid diagnosis is key to controlling the disease, yet the traditional tests for TB produce results that are either inaccurate or take too long to be definitive. A fast and reliable diagnostic method tha...

journal_title：Expert review of anti-infective therapy

authors： Al-Zamel FA

更新日期：2009-11-01 00:00:00

abstract：:Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seede...

journal_title：Expert review of anti-infective therapy

authors： Dahlén G,Ebenfelt A

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Multidrug-resistant (MDR) and extensively-drug-resistant (XDR) Gram-negative bacteria have emerged as a major threat to human health globally. This has resulted in the 're-discovery' of some older antimicrobials and development of new agents, however resistance has also rapidly emerged to these agents. Are...

journal_title：Expert review of anti-infective therapy

authors： Sherry N,Howden B

更新日期：2018-04-01 00:00:00

abstract：:Introduction: Neonatal sepsis remains a serious and potentially fatal illness. Intrapartum antibiotic prophylaxis (IAP) prevents group B streptococcal (GBS) early-onset sepsis. The optimal duration of IAP (adequate IAP) to reduce vertical transmission of GBS has been debated. Understanding the mechanism of action of I...

journal_title：Expert review of anti-infective therapy

authors： Berardi A,Spada C,Vaccina E,Boncompagni A,Bedetti L,Lucaccioni L

更新日期：2020-01-01 00:00:00

abstract：:The development of HIV-1 integrase strand transfer inhibitors (INSTIs) has been a major therapeutic breakthrough in the management of HIV-1 infection. The first HIV-1 integrase inhibitor, raltegravir, was licensed in 2007 and was subsequently approved for use in treatment-naive patients. Since then, newer members of t...

journal_title：Expert review of anti-infective therapy

authors： Lampiris HW

更新日期：2012-01-01 00:00:00

abstract：:Invasive candidiasis, including candidemia (IC/C), is a major cause of morbidity and mortality among hospitalized patients. While incidence is higher in intensive care units, the majority of cases of candidemia are documented in medical wards. Although Candida albicans is still the most frequently isolated species, IC...

journal_title：Expert review of anti-infective therapy

authors： Tagliaferri E,Menichetti F

更新日期：2015-06-01 00:00:00

abstract：:In susceptible patients, invasive aspergillosis has a high incidence and a mortality of up to 80%. The diagnosis of this condition is difficult, especially in the early stages of the disease and, as a consequence, antifungal therapy, despite its expense and toxicity, is often initiated empirically. Until recently, the...

journal_title：Expert review of anti-infective therapy

authors： Doffman SR,Agrawal SG,Brown JS

更新日期：2005-08-01 00:00:00

abstract：:Cryptosporidiosis, the disease caused by protozoa of the genus Cryptosporidium, represents a major public health problem in both developing and developed countries. The infection can be severe and life threatening among immunocompromised individuals, particularly in AIDS patients and in those with primary immunodefici...

journal_title：Expert review of anti-infective therapy

authors： Cacciò SM,Pozio E

更新日期：2006-06-01 00:00:00

abstract：:The emergence of multidrug-resistant tuberculosis strains and the coinfection with HIV, together with advances in immunology, have led to renewed interest regarding ways to exploit the immune responses against Mycobacterium tuberculosis therapeutically. Here we review the fundamentals of tuberculosis therapy in view o...

journal_title：Expert review of anti-infective therapy

authors： Achkar JM,Casadevall A,Glatman-Freedman A

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:The emergence and spread of antibiotic resistance among pathogenic bacteria drives the search for alternative antimicrobial therapies. Bacteriocins represent a potential alternative to antibiotic treatment. In contrast to antibiotics, bacteriocins are peptides or proteins that have relatively narrow spectr...

journal_title：Expert review of anti-infective therapy

authors： Bosák J,Hrala M,Micenková L,Šmajs D

更新日期：2020-09-22 00:00:00

abstract：:Lopinavir is a protease inhibitor (PI) for the treatment of HIV infection that was specifically designed to overcome the shortcomings of earlier agents in this class. It is the only PI coformulated with ritonavir, whose pharmacological boosting effect results in a highly potent, well-tolerated, clinically effective an...

journal_title：Expert review of anti-infective therapy

authors： Tan D,Walmsley S

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units. METHODS:This was a retrospective matched case-control study of patients admi...

journal_title：Expert review of anti-infective therapy

authors： Aleidan FAS,Alkhelaifi H,Alsenaid A,Alromaizan H,Alsalham F,Almutairi A,Alsulaiman K,Abdel Gadir AG

更新日期：2020-09-20 00:00:00

abstract：:The use of combination antiretroviral therapy for the prevention of mother to child transmission of HIV infection has achieved vertical HIV transmission rates of <1%. The use of these drugs is not without risk to the mother and infant. Pregnant women with HIV-infection are at high risk of preterm birth (PTB <37 weeks)...

journal_title：Expert review of anti-infective therapy

authors： Short CE,Taylor GP

更新日期：2014-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection spreads primarily via contact with infected blood and can establish a persistent infection in 80% of infected individuals, progressively causing chronic liver disease that can lead to hepatocellular carcinoma or end-stage liver disease requiring a transplant. There is no vaccine, and ...

journal_title：Expert review of anti-infective therapy

authors： Stamataki Z

更新日期：2010-09-01 00:00:00

abstract：:Invasive yeast infections are a significant cause of morbidity and mortality in patients with defective immune response, such as those with cancer-related immunosuppression, organ transplantation or other immunodeficiencies, and neonates. Hospitalization in the intensive care unit may increase the risk for such infect...

journal_title：Expert review of anti-infective therapy

authors： Garbino J,Katragkou A,Roilides E

更新日期：2007-02-01 00:00:00

abstract：:Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

journal_title：Expert review of anti-infective therapy

authors： Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

更新日期：2013-11-01 00:00:00

abstract：:Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections and a yearly boost. Many experts agree that it is now time for the next...

journal_title：Expert review of anti-infective therapy

authors： Tournier JN,Ulrich RG,Quesnel-Hellmann A,Mohamadzadeh M,Stiles BG

更新日期：2009-03-01 00:00:00

abstract：:Antifungal susceptibility testing should identify in vitro resistance among a normally susceptible population or should detect the development of resistance during therapy. The Clinical and Laboratory Standards Institute (CLSI; formerly the National Committee for Clinical Laboratory Standards [NCCLS]) has developed re...

journal_title：Expert review of anti-infective therapy

authors： Cantón E,Espinel-Ingroff A,Pemán J

更新日期：2009-02-01 00:00:00

abstract：:Cationic antimicrobial peptides are a novel type of antibiotic offering much potential in the treatment of microbial-related diseases. They offer many advantages for commercial development, including a broad spectrum of action and modest size. However, despite the identification or synthetic production of thousands of...

journal_title：Expert review of anti-infective therapy

authors： Hale JD,Hancock RE

更新日期：2007-12-01 00:00:00

abstract：:HIV-associated nephropathy (HIVAN) is the most well-known and aggressive kidney disease in HIV-1-infected patients. A variant of focal segmental glomerulosclerosis, it is characterized by the collapse of the glomerular tuft with podocyte hypertrophy/hyperplasia and foot process effacement, often with concurrent tubula...

journal_title：Expert review of anti-infective therapy

authors： Atta MG,Lucas GM,Fine DM

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations. AREAS COVERED:Unfortunately, data in the pediatric age group remain difficult to interpret. However, epi...

journal_title：Expert review of anti-infective therapy

authors： Principi N,Esposito S

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Pneumocystis jirovecii is a ubiquitous fungus, which causes pneumonia in humans. Diagnosis was hampered by the inability to culture the organism, and based on microscopic examination of respiratory samples or clinical presentation. New assays can assist in the diagnosis and even aid with the emergence of r...

journal_title：Expert review of anti-infective therapy

authors： White PL,Backx M,Barnes RA

更新日期：2017-05-01 00:00:00

abstract：:Hepatitis E, caused by hepatitis E virus, is a disease of global significance, causing 20 million infections each year. Genotypes 1 and 2 have vastly different epidemiological patterns from genotypes 3 and 4. In genotype 1 and 2 endemic areas, most infections and illness occur in persons 15-30 years of age, with pregn...

journal_title：Expert review of anti-infective therapy

authors： Kmush BL,Nelson KE,Labrique AB

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite...

journal_title：Expert review of anti-infective therapy

authors： Rath B,Conrad T,Myles P,Alchikh M,Ma X,Hoppe C,Tief F,Chen X,Obermeier P,Kisler B,Schweiger B

更新日期：2017-06-01 00:00:00

abstract：:In recent decades, the incidence of aspergillosis, candidiasis and clinically important deep mycoses has been increasing, with advances in transplantation medicine and anticancer chemotherapy. Micafungin (FK463, Fujisawa Healthcare) has been developed as a novel type of antifungal agent, which inhibits 1,3-beta-D-gluc...

journal_title：Expert review of anti-infective therapy

authors： Higashiyama Y,Kohno S

更新日期：2004-06-01 00:00:00

abstract：INTRODUCTION:Septic arthritis (SA) is an orthopedic emergency in childhood. It is uncommon in high resource settings. However, an incidence of 5-20 per 100,000 children has been reported in low-income countries. Area covered: The predictive value of serum markers is still under debate and the proposed diagnostic algori...

journal_title：Expert review of anti-infective therapy

authors： Chiappini E,Mastrolia MV,Galli L,De Martino M,Lazzeri S

更新日期：2016-11-01 00:00:00

abstract：:The advent of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV. A wide variety of antiretroviral agents are now available, allowing patients and physicians a choice of effective therapy. However, drug resistance and toxicities are emerging as major treatment challenges in the HAART ...

journal_title：Expert review of anti-infective therapy

authors： Jones R,Gazzard B

更新日期：2006-04-01 00:00:00

abstract：:Since the advent of combined antiretroviral therapy there have been reductions in mortality and morbidity from HIV, transforming the disease into a chronic medical condition where newly diagnosed individuals can expect to live a near-normal life expectancy. When choosing therapy, probably the most important considerat...

journal_title：Expert review of anti-infective therapy

authors： Scourfield A,Waters L,Nelson M

更新日期：2011-11-01 00:00:00