当前位置： SCI文献检索 > ADDICTIVE BEHAVIORS期刊下所有文献 > Medication adherence and rate of nicotine metabolism are associated with response to treatment with varenicline among smokers with HIV.

Medication adherence and rate of nicotine metabolism are associated with response to treatment with varenicline among smokers with HIV.

Abstract：

INTRODUCTION:PLWHA who smoke have shown lower cessation rates within placebo-controlled randomized trials of varenicline. Adherence and rate of nicotine metabolism may be associated with quit rates in such clinical trials. METHODS:This secondary analysis of a randomized placebo-controlled trial of varenicline for smoking among PLWHA (N = 179) examined the relationship between varenicline adherence (pill count, ≥80% of pills), nicotine metabolism (based on the nicotine metabolite ratio; NMR) and end-of-treatment smoking cessation (self-reported 7-day point prevalence abstinence, confirmed with carbon monoxide of ≤ 8 ppm, at the end of treatment; EOT). RESULTS:Combining varenicline and placebo arms, greater adherence (OR = 1.011, 95% CI:1.00-1.02, p = 0.051) and faster nicotine metabolism (OR = 3.08, 95% CI:1.01-9.37, p = 0.047) were related to higher quit rates. In separate models, adherence (OR = 1.009, 95% CI:1.004-1.01, p < 0.001) and nicotine metabolism rate (OR = 2.04, 95% CI:1.19-3.49, p = 0.009) interacted with treatment arm to effect quit rates. The quit rate for varenicline vs. placebo was higher for both non-adherent (19% vs. 5%; χ2[1] = 2.80, p = 0.09) and adherent (35% vs. 15%; χ2[1] = 6.51, p = 0.01) participants, but the difference between treatment arms was statistically significant only for adherent participants. Likewise, among slow metabolizers (NMR < 0.31), the varenicline quit rate was not significantly higher vs. placebo (14% vs. 5%; χ2[1] = 1.17, p = 0.28) but, among fast metabolizers (NMR ≥ 0.31), the quit rate for varenicline was significantly higher vs. placebo (33% vs. 14%; χ2[1] = 4.43, p = 0.04). CONCLUSIONS:Increasing varenicline adherence and ensuring that fast nicotine metabolizers receive varenicline may increase quit rates for PLWHA.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Bauer AM,Hosie Quinn M,Lubitz SF,Flitter A,Ashare RL,Leone FT,Gross R,Hitsman B,Schnoll R

doi

10.1016/j.addbeh.2020.106638

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

106638

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(20)30768-1

journal_volume

112

pub_type

杂志文章

在线工具

Medication adherence and rate of nicotine metabolism are associated with response to treatment with varenicline among smokers with HIV.