Pattern regulation in a regenerating jellyfish.

Abstract:

:Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning mechanisms during regeneration. Here we show that an interplay between mechanical forces, cell migration and proliferation allows jellyfish fragments to regain shape and functionality rapidly, notably by efficient restoration of the central feeding organ (manubrium). Fragmentation first triggers actomyosin-powered remodeling that restores body umbrella shape, causing radial smooth muscle fibers to converge around 'hubs' which serve as positional landmarks. Stabilization of these hubs, and associated expression of Wnt6, depends on the configuration of the adjoining muscle fiber 'spokes'. Stabilized hubs presage the site of the manubrium blastema, whose growth is Wnt/β-catenin dependent and fueled by both cell proliferation and long-range cell recruitment. Manubrium morphogenesis is modulated by its connections with the gastrovascular canal system. We conclude that body patterning in regenerating jellyfish emerges mainly from local interactions, triggered and directed by the remodeling process.

journal_name

Elife

journal_title

eLife

authors

Sinigaglia C,Peron S,Eichelbrenner J,Chevalier S,Steger J,Barreau C,Houliston E,Leclère L

doi

10.7554/eLife.54868

subject

Has Abstract

pub_date

2020-09-07 00:00:00

issn

2050-084X

pii

54868

journal_volume

9

pub_type

杂志文章

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