Cellular immunotherapy in breast cancer: The quest for consistent biomarkers.

Abstract:

:Breast cancer is the most common malignancy in women worldwide, with a relatively high proportion of patients experiencing resistance to standard treatments. Cellular immunotherapy (CI), which is based on the extraction, modification, and re-infusion of the patient's immune cells, is showing promising results in these patients. Among CI possible approaches, adoptive cell therapy (ACT) and dendritic cell (DC) vaccination are the most comprehensively explored in both primary/translational research studies and clinical trials. ACT may include the use of tumor-infiltrating lymphocytes (TILs), T cell receptor (TCR)-, or chimeric antigen receptor (CAR)-engineered T-cells. There are indications suggesting that a biomarker-based approach might be beneficial in effectively selecting breast cancer patients for CI. Here, we sought to provide the current knowledge of CI in breast cancer, focusing on candidate biomarkers, ongoing clinical trials, limitations, and immediate future perspectives.

journal_name

Cancer Treat Rev

journal_title

Cancer treatment reviews

authors

Venetis K,Invernizzi M,Sajjadi E,Curigliano G,Fusco N

doi

10.1016/j.ctrv.2020.102089

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

102089

eissn

0305-7372

issn

1532-1967

pii

S0305-7372(20)30127-4

journal_volume

90

pub_type

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