MAC5, an RNA-binding protein, protects pri-miRNAs from SERRATE-dependent exoribonuclease activities.

abstract：:γ-Secretase is an intramembrane-cleaving protease responsible for the generation of amyloid-β (Aβ) peptides. Recently, a series of compounds called γ-secretase modulators (GSMs) has been shown to decrease the levels of long toxic Aβ species (i.e., Aβ42), with a concomitant elevation of the production of shorter Aβ spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeo K,Tanimura S,Shinoda T,Osawa S,Zahariev IK,Takegami N,Ishizuka-Katsura Y,Shinya N,Takagi-Niidome S,Tominaga A,Ohsawa N,Kimura-Someya T,Shirouzu M,Yokoshima S,Yokoyama S,Fukuyama T,Tomita T,Iwatsubo T

更新日期：2014-07-22 00:00:00

abstract：:RNA interfering is a eukaryote-specific gene silencing by 20∼23-nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been known as the only slicer while Argonaute3 (AGO3) barely cleaves RNAs. Therefore, the intrinsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park MS,Sim G,Kehling AC,Nakanishi K

更新日期：2020-11-17 00:00:00

abstract：:The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel-Lindau tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

更新日期：2002-08-06 00:00:00

abstract：:By commandeering cellular translation initiation factors, or destroying those dispensable for viral mRNA translation, viruses often suppress host protein synthesis. In contrast, cellular protein synthesis proceeds in human cytomegalovirus (HCMV)-infected cells, forcing viral and cellular mRNAs to compete for limiting ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKinney C,Perez C,Mohr I

更新日期：2012-04-10 00:00:00

abstract：:Social decisions require evaluation of costs and benefits to oneself and others. Long associated with emotion and vigilance, the amygdala has recently been implicated in both decision-making and social behavior. The amygdala signals reward and punishment, as well as facial expressions and the gaze of others. Amygdala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Fagan NA,Toda K,Utevsky AV,Pearson JM,Platt ML

更新日期：2015-12-29 00:00:00

abstract：:Polysomes (S-20) from homogenates of guinea pig liver synthesized serum albumin and a precursor of the fourth component of guinea pig complement (C4) in vitro. The C4 precursor (pro-C4) accounted for approximately 0.2% and albumin 4% of the radiolabeled protein precipitable by trichloroacetic acid and not bound to pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall RE,Colten HR

更新日期：1977-04-01 00:00:00

abstract：:In a field study, we show that a young song sparrow (i) selects his songs from three or four older birds who have neighboring territories, (ii) preferentially learns song types that these tutor neighbors share, and (iii) ultimately sets up his territory next to, or replaces, one of these tutor neighbors. The consequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beecher MD,Campbell SE,Stoddard PK

更新日期：1994-02-15 00:00:00

abstract：:Oscillations in intracellular free calcium concentration ([Ca(2+)](i)) occur spontaneously in immature neurons of the developing cerebral cortex. Here, we show that developing murine cortical neurons exhibit calcium oscillations in response to direct activation of the mGluR5 subtype of the group I metabotropic glutama...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flint AC,Dammerman RS,Kriegstein AR

更新日期：1999-10-12 00:00:00

abstract：:Dynamic signals linking the actin cytoskeleton and cell adhesion receptors are essential for morphogenesis during development and normal tissue homeostasis. Abi1 is a central regulator of actin polymerization through interactions with multiple protein complexes. However, the in vivo role of Abi1 remains to be defined....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring C,Ginsberg MH,Haling J,Pendergast AM

更新日期：2011-01-04 00:00:00

abstract：:Water freezing on solid surfaces is ubiquitous in nature. Even though icing/frosting impairs the performance and safety in many processes, its mechanism remains inadequately understood. Changing atmospheric conditions, surface properties, the complexity of icing physics, and the unorthodox behavior of water are the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung S,Tiwari MK,Poulikakos D

更新日期：2012-10-02 00:00:00

abstract：:Complement receptors (CRs), expressed notably on myeloid and lymphoid cells, play an essential function in the elimination of complement-opsonized pathogens and apoptotic/necrotic cells. In addition, these receptors are crucial for the cross-talk between the innate and adaptive branches of the immune system. CR3 (also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bajic G,Yatime L,Sim RB,Vorup-Jensen T,Andersen GR

更新日期：2013-10-08 00:00:00

abstract：:Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the γδ-TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl SP,Coffey F,Kain L,Zarin P,Dunbrack RL Jr,Teyton L,Zúñiga-Pflücker JC,Kappes DJ,Wiest DL

更新日期：2018-02-20 00:00:00

abstract：:Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)-based, experimental therapeutic to be administered to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Gritli I,Tolcher A,Heidel JD,Lim D,Morgan R,Chmielowski B,Ribas A,Davis ME,Yen Y

更新日期：2014-08-05 00:00:00

abstract：:Noninvasive prenatal testing using fetal DNA in maternal plasma is an actively researched area. The current generation of tests using massively parallel sequencing is based on counting plasma DNA sequences originating from different genomic regions. In this study, we explored a different approach that is based on the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu SC,Chan KC,Zheng YW,Jiang P,Liao GJ,Sun H,Akolekar R,Leung TY,Go AT,van Vugt JM,Minekawa R,Oudejans CB,Nicolaides KH,Chiu RW,Lo YM

更新日期：2014-06-10 00:00:00

abstract：:Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse fundamental processes in the lung. Here we report that the arginine transport protein, cationic amino acid transporter (CAT)2, has a critical role in regulating lung inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothenberg ME,Doepker MP,Lewkowich IP,Chiaramonte MG,Stringer KF,Finkelman FD,MacLeod CL,Ellies LG,Zimmermann N

更新日期：2006-10-03 00:00:00

abstract：:Recombination between unirradiated chromosomes was induced by UV or x-ray irradiation of haploids followed by a mating with heteroallelic diploids of Saccharomyces cerevisiae. The selected event of intragenic recombination did not involve the participation of the irradiated chromosome and apparently was not caused by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fabre F,Roman H

更新日期：1977-04-01 00:00:00

abstract：:Expression of the bacterial RecA protein in plants stimulates homologous recombination in tobacco. Here we show that RecA plays a direct role in DNA strand exchange in vivo. The number of sister chromatid exchanges (SCEs) was increased 2.4-fold over wild type in transgenic tobacco plants expressing a nuclear-targeted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiss B,Schubert I,Köpchen K,Wendeler E,Schell J,Puchta H

更新日期：2000-03-28 00:00:00

abstract：:Developing tools for investigating the cellular activity of glycans will help to delineate the molecular basis for aberrant glycosylation in pathological processes such as cancer. Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu TL,Hanson SR,Kishikawa K,Wang SK,Sawa M,Wong CH

更新日期：2007-02-20 00:00:00

abstract：:Evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with Alzheimer's disease. One of the more prominent effects of cholinergic agonists on hippocampal ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MJ,Rouse ST,Levey AI,Potter LT,Conn PJ

更新日期：1998-09-15 00:00:00

abstract：:The CRR1 (Copper Response Regulator) locus, required for both activating and repressing target genes of a copper- and hypoxia-sensing pathway in Chlamydomonas, encodes a 1,232-residue candidate transcription factor with a plant-specific DNA-binding domain named SBP, ankyrin repeats, and a C-terminal Cys-rich region, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kropat J,Tottey S,Birkenbihl RP,Depège N,Huijser P,Merchant S

更新日期：2005-12-20 00:00:00

abstract：:Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sox HC Jr,Hood L

更新日期：1970-07-01 00:00:00

abstract：:Histidine biosynthesis is an essential process in plants and microorganisms, making it an attractive target for the development of herbicides and antibacterial agents. Imidazoleglycerol-phosphate dehydratase (IGPD), a key enzyme within this pathway, has been biochemically characterized in both Saccharomyces cerevisiae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawson S,Bisson C,Hurdiss DL,Fazal A,McPhillie MJ,Sedelnikova SE,Baker PJ,Rice DW,Muench SP

更新日期：2018-02-20 00:00:00

abstract：:The only major glutamate receptor membrane-associated guanylate kinase scaffolds expressed in the young superficial superior colliculus (SC) are synapse-associated protein 102 (SAP102) and postsynaptic density protein 95 (PSD95). In this, as in all visual brain regions examined, synaptic PSD95 increases rapidly follow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao JP,Murata Y,Constantine-Paton M

更新日期：2013-01-08 00:00:00

abstract：:Data drawn from a global compilation of studies quantitatively confirm the long-articulated contention that erosion rates from conventionally plowed agricultural fields average 1-2 orders of magnitude greater than rates of soil production, erosion under native vegetation, and long-term geological erosion. The general ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery DR

更新日期：2007-08-14 00:00:00

abstract：:The Hawaiian honeycreepers (Drepanidae) represent a superb illustration of evolutionary radiation, with a single colonization event giving rise to 19 extant and at least 10 extinct species [Curnutt, J. & Pimm, S. (2001) Stud. Avian Biol. 22, 15-30]. They also represent a dramatic example of anthropogenic extinction. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benning TL,LaPointe D,Atkinson CT,Vitousek PM

更新日期：2002-10-29 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) obtained from human melanomas can specifically lyse autologous tumor in vitro and mediate tumor regression in vivo. To develop more effective therapeutic reagents and to further understand the T-cell response to tumors, the diversity of T-cell receptors (TCRs) involved in melanoma ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shilyansky J,Nishimura MI,Yannelli JR,Kawakami Y,Jacknin LS,Charmley P,Rosenberg SA

更新日期：1994-03-29 00:00:00

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang X,Gu L,Qi J,Correa S,Zhang G,Belcher AM,Hammond PT

更新日期：2016-05-10 00:00:00

abstract：:Neurons in the cochlear nuclei of duck embryos become responsive to tonal stimuli in an orderly spatial and temporal sequence. Cells responding to lower frequencies are recorded before those responding to higher frequencies. Auditory neurons are spatially arranged according to their characteristic frequencies, indicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konishi M

更新日期：1973-06-01 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Park SH,Pantazides BG,Karpiuk O,Warren MD,Hardy CW,Duong DM,Park SJ,Kim HS,Vassilopoulos A,Seyfried NT,Johnsen SA,Gius D,Yu DS

更新日期：2013-08-13 00:00:00

abstract：:Synapsins are abundant synaptic-vesicle phosphoproteins that are known to regulate neurotransmitter release but whose precise function has been difficult to pinpoint. Here, we use knockout mice to analyze the role of synapsins 1 and 2 in the calyx of Held synapse, allowing precise measurements of neurotransmitter rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun J,Bronk P,Liu X,Han W,Südhof TC

更新日期：2006-02-21 00:00:00