Abstract:
:Panton-Valentine leukocidin (PVL) represents an important virulence factor for many strains of Staphylococcus aureus. PVL is an esotoxin causing leucocyte destruction and tissue necrosis. We report on a case of osteomyelitis involving the hip joint with thromblophlebitis complicated by necrotizing pneumonia and life-threatening septic shock. The child required advance respiratory support for 14 days with circulatory support for 7 days in ICU (intensive care unit), surgical draninage via arthrotomy of hip joint and second-line antibiotic treatment for 1 month. Among a wide literature, in Europe over half of Panton-Valentine St. Aureus (PVL-SA) is MSSA. Investigations for PVL are not always available determining an under-recognition of the episodes. Data on prevalence of PVL-SA in Italy are scarce. With this clinical report, we emphasize the recognition of clinical features that must lead to suspect PVL-SA osteomyelitis in children, providing their adequate management.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
ADVANCES IN MUSCULOSKELETAL DISEASES AND INFECTIONS - SOTIMI 2019:.,Cori MS,Ronconi G,Masiello E,Valentini P,Ferriero G,Maccauro G,Ferrara PEsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
53-56issue
3 Suppl. 2eissn
0393-974Xissn
1724-6083pii
8journal_volume
34pub_type
abstract::Intravenous IgG has been adopted as treatment for various immune-related diseases, including immune thrombocytopenic purpura, autoimmune neuropathies, systemic lupus erythematosus, Guillain-Barré syndrome, myasthenia gravis, Kawasaki disease, skin blistering diseases. The intravenous administration of exogenously pool...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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doi:10.23812/EDITORIAL-RONCONI-E-59
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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更新日期:2013-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
doi:
更新日期:2012-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2016-01-01 00:00:00
abstract::To investigate the role played by chemokines in the natural history of human immunodeficiency virus (HIV) infection, we measured the plasma levels of RANTES. MIP-1 alpha and MIP-1 beta in a cohort of patients with primary HIV-1 infection (PHI) followed longitudinally. The cohort included 17 patients with well-document...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
abstract::S6K1 regulation associates a central role with dynamics of sequential phosphorylations at the hydrophobic motif (T412) and activation loop (T252) of the enzyme, such that the hydrophobic motif phosphorylation supposedly brought about by mTOR- kinase, primes the enzyme for PDK1 dependent phosphorylation at the activati...
journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2013-04-01 00:00:00
abstract::Scleroderma is a chronic systemic autoimmune disease (primarily of the skin) characterized by fibrosis (or hardening), vascular alterations and autoantibodies production.There are currently no effective therapies against this devastating and often lethal disorder. Despite the interest for the immunomodulatory effects ...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::It has been postulated that host factors, such as the human leucocyte antigen (HLA) system, may play a predominant role in the pathogenesis of HCV-related extra-hepatic manifestations. This study was performed to investigate the role of HLA- DR and DQ alleles in a group of Italian patients, with HCV infection and asso...
journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件,多中心研究,随机对照试验
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journal_title:Journal of biological regulators and homeostatic agents
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