Abstract:
BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for acute kidney injury (AKI) prediction. However, studies on whether using both plasma NGAL (PNGAL) and urine NGAL (UNGAL) can improve AKI prediction are limited. We investigated the best approach to predict AKI in high-risk patients when using PNGAL and UNGAL together. METHODS:We enrolled 151 AKI suspected patients with one or more AKI risk factors. We assessed the diagnostic performance of PNGAL and UNGAL for predicting AKI according to chronic kidney disease (CKD) status by determining the areas under the receiver operating curve (AuROC). Independent predictors of AKI were assessed using univariate and multivariate logistic regression analyses. RESULTS:In the multivariate logistic regression analysis for all patients (N=151), Model 2 and 3, including PNGAL (P=0.012) with initial serum creatinine (S-Cr), showed a better AKI prediction power (R2=0.435, both) than Model 0, including S-Cr only (R2=0.390). In the non-CKD group (N=135), the AuROC of PNGAL for AKI prediction was larger than that of UNGAL (0.79 vs 0.66, P=0.010), whereas in the CKD group (N=16), the opposite was true (0.94 vs 0.76, P=0.049). CONCLUSIONS:PNGAL may serve as a useful biomarker for AKI prediction in high-risk patients. However, UNGAL predicted AKI better than PNGAL in CKD patients. Our findings provide guidance for selecting appropriate specimens for NGAL testing according to the presence of CKD in AKI high-risk patients.
journal_name
Ann Lab Medjournal_title
Annals of laboratory medicineauthors
Yi A,Lee CH,Yun YM,Kim H,Moon HW,Hur Mdoi
10.3343/alm.2021.41.1.60subject
Has Abstractpub_date
2021-01-01 00:00:00pages
60-67issue
1eissn
2234-3806issn
2234-3814pii
alm-2021-41-1-60journal_volume
41pub_type
杂志文章abstract:BACKGROUND:We developed a single-color multitarget flow cytometry (SM-FC) assay, a single-tube assay with graded mean fluorescence intensities (MFIs). We evaluated the repeatability of SM-FC, and its correlation with multicolor flow cytometry (MFC), to assess its application as a routine FC assay. METHODS:We selected ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2012.32.3.171
更新日期:2012-05-01 00:00:00
abstract::ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here, we describe a case of IgM deficiency discovered during the eva...
journal_title:Annals of laboratory medicine
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journal_title:Annals of laboratory medicine
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abstract:BACKGROUND:The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the poten...
journal_title:Annals of laboratory medicine
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abstract:BACKGROUND:The Automated Fluorescent Immunoassay System (AFIAS) rotavirus assay (Boditech Med Inc., Chuncheon, Korea) is a new rapid antigen test for rotavirus detection. We evaluated the performance of this assay for detecting rotaviruses and their specific genotypes in clinical stool samples. METHODS:AFIAS rotavirus...
journal_title:Annals of laboratory medicine
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abstract:BACKGROUND:Hepatitis E virus (HEV) causes epidemics in developing countries and is primarily transmitted through the fecal-oral route. There have been recent reports on the zoonotic spread of the virus, and several animal species, primarily pigs, have been recognized as reservoirs of HEV. Because of its possible spread...
journal_title:Annals of laboratory medicine
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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abstract::Procalcitonin (PCT) is used as a biomarker for the diagnosis of sepsis, severe sepsis and septic shock. At the same time, PCT has also been used to guide antibiotic therapy. This review outlines the main indications for PCT measurement and points out possible pitfalls. The classic indications for PCT measurement are: ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes six to eight weeks, molecular assays are widely used to determine drug resistance. ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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journal_title:Annals of laboratory medicine
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2012.32.1.57
更新日期:2012-01-01 00:00:00
abstract::Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2020.40.4.312
更新日期:2020-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
abstract::[This corrects the article on p. 439 in vol. 40.]. ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章,已发布勘误
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更新日期:2021-01-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2016.36.4.362
更新日期:2016-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2014.34.5.372
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Mutations in calreticulin (CALR) have been reported to be key markers in the molecular diagnosis of myeloid proliferative neoplasms. In most previous reports, CALR mutations were analyzed by using Sanger sequencing. Here, we report a new, rapid, and convenient system for screening CALR mutations without sequ...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2016.36.4.291
更新日期:2016-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2020.40.5.370
更新日期:2020-09-01 00:00:00
abstract::Coagulase-negative staphylococci (CoNS) are reported to be the leading cause of nosocomial bloodstream infections. Staphylococcus pettenkoferi is a novel member of CoNS that was first isolated from the human blood and bursitis wound in 2002. We have reported cases of 6 S. pettenkoferi strains isolated from blood speci...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2015.35.2.250
更新日期:2015-03-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2015.35.3.321
更新日期:2015-05-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2013.33.4.248
更新日期:2013-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2012.32.6.413
更新日期:2012-11-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2015.35.4.458
更新日期:2015-07-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2016.36.3.223
更新日期:2016-05-01 00:00:00
abstract:Background:Plasma cell myeloma (PCM) is caused by immune dysregulation. We evaluated the expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets in PCM patients according to disease course and cytogenetic abnormalities. This study aimed to find a target group suitable for therapeutic us...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2021-05-01 00:00:00
abstract::Long QT syndrome (LQTS) is an inherited cardiac disease characterized by a prolonged heart rate-corrected QT (QTc) interval. We investigated the genetic causes in patients with prolonged QTc intervals who were negative for pathogenic variants in three major LQTS-related genes (KCNQ1, KCNH2, and SCN5A). Molecular genet...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2018.38.1.54
更新日期:2018-01-01 00:00:00
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journal_title:Annals of laboratory medicine
pub_type: 杂志文章
doi:10.3343/alm.2020.40.1.57
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:ChromID Clostridium difficile agar (IDCd; bioMérieux SA, France) is a recently developed chromogenic medium for rapid and specific isolation of C. difficile. We compared the performance of IDCd with that of Clostridium difficile Selective Agar (CDSA). METHODS:A total of 530 fresh stool specimens were collec...
journal_title:Annals of laboratory medicine
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Annals of laboratory medicine
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更新日期:2016-09-01 00:00:00
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更新日期:2016-01-01 00:00:00