Abstract：
RESEARCH QUESTION:Does the use of preimplantation genetic testing for aneuploidies (PGT-A) improve outcomes in couples with severe male factor infertility (SMFI)? DESIGN:This retrospective cohort study included SMFI cases that underwent blastocyst transfer with/without PGT-A. Inclusion criteria were SMFI (azoospermia and sperm count <1 million/ml), women aged 25-39 years, single vitrified-warmed blastocyst transfer, and no intracavitary pathologies. Patients were divided into PGT-A and non-PGT-A groups. The primary outcome was live birth rate (live birth of an infant after 24 weeks of gestation); secondary outcomes were implantation and clinical pregnancy rates. RESULTS:The study included 266 SMFI cases (90 and 176 in the PGT-A and non-PGT-A groups, respectively). Men and women in the PGT-A group were significantly older than those in the non-PGT-A group. The groups did not differ in terms of male factor categories, sperm collection methods or additional female factors. Live birth rates in the PGT-A and non-PGT-A groups were 55.6% and 51.1%, respectively (odds ratio [OR] 1.19, 95% confidence interval [CI] 0.71-1.98, P = 0.495). The implantation rates were 65.6% and 64.2%, respectively (OR 1.06, 95% CI 0.62-1.80, P = 0.827). The clinical pregnancy rates were 62.2% and 58.0%, respectively (OR 1.19, 95% CI 0.71-2.01, P = 0.502). The use of PGT-A was not an independent factor for live birth (aOR 1.33, 95% CI 0.66-2.70, P = 0.421). Advanced age in women was the only independent factor associated with live birth (aOR 0.46, 95% CI 0.22-0.96, P = 0.041). CONCLUSIONS:The use of PGT-A does not seem to be an independent factor associated with live birth per transfer in couples with SMFI.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Asoglu MR,Celik C,Serefoglu EC,Findikli N,Bahceci Mdoi
10.1016/j.rbmo.2020.06.015subject
Has Abstractpub_date
2020-10-01 00:00:00pages
595-603issue
4eissn
1472-6483issn
1472-6491pii
S1472-6483(20)30340-0journal_volume
41pub_type
杂志文章abstract：:This paper draws on the findings of the first survey of surrogacy arrangements in Human Fertilisation and Embryology Authority (HFEA) licensed fertility clinics since 1998. Given the complex social, ethical and legal issues involved, surrogacy continues to raise debate worldwide and fuel calls for increased domestic p...
journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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abstract：:Quality management according to ISO 9001:2008 guidelines includes infertility care quality assessment and improvement. This study aimed to describe the development process of a questionnaire for infertility management. A literature review, qualitative interviews with experts and patients resulted in a content-valid an...
journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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更新日期：2017-12-01 00:00:00
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journal_title：Reproductive biomedicine online
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doi：10.1016/j.rbmo.2010.02.025
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journal_title：Reproductive biomedicine online
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doi：10.1016/s1472-6483(10)60068-5
更新日期：2009-08-01 00:00:00
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journal_title：Reproductive biomedicine online
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更新日期：2016-06-01 00:00:00
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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更新日期：2019-05-01 00:00:00
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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更新日期：2008-05-01 00:00:00
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
pub_type： 杂志文章,评审
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更新日期：2008-04-01 00:00:00
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journal_title：Reproductive biomedicine online
pub_type： 杂志文章
doi：10.1016/j.rbmo.2011.05.009
更新日期：2011-09-01 00:00:00
abstract：:Cleavage kinetics of human embryos is indicative of ability to develop to blastocyst and implant. Recent advances in time-lapse microscopy have opened new and important research opportunities. In this study involving infertile couples requiring standard IVF/intracytoplasmic sperm injection treatment, zygotes were cult...
journal_title：Reproductive biomedicine online
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