Abstract:
:While infectious bursal disease virus (IBDV) mainly targets immature B cells and causes T cell infiltration in the bursa of Fabricius (BF) of chickens, the effect of IBDV infection on the properties of T cells and relevant cytokine production in avian gut-associated lymphoid tissues (GALTs) remains unknown. Here, we show that while the CD8+ T cell subset is not affected, IBDV infection decreases the percentage of CD4+ T cells in the cecal tonsil (CT), but not in esophagus tonsil, pylorus tonsil, and Meckel's diverticulum of GALTs, in contrast to BF and spleen, in which the proportion of CD4+ cells increases upon IBDV infection. Further, IBDV infection upregulates IFN-γ, IL-10, and the T cell checkpoint receptor LAG-3 mRNA expression in BF. In contrast, in CTs, IBDV infection significantly increases the production of IFN-β and CTLA-4 mRNA, while no significant effect is seen in the case of IFN-γ, IL-10 and LAG-3. Together, our data reveal differential modulation of T cell subsets and proinflammatory cytokine production in different lymphoid tissues during the course of IBDV infection.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Ruan Y,Wang Y,Guo Y,Xiong Y,Chen M,Zhao A,Liu Hdoi
10.1007/s00705-020-04735-ysubject
Has Abstractpub_date
2020-10-01 00:00:00pages
2249-2258issue
10eissn
0304-8608issn
1432-8798pii
10.1007/s00705-020-04735-yjournal_volume
165pub_type
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