Abstract：
AIMS:Data on the association of cardiorespiratory fitness with survival of cancer patients are limited. This study aimed to evaluate the association between midlife cardiorespiratory fitness and survival after a subsequent cancer diagnosis. METHODS:We evaluated 19,134 asymptomatic self-referred adults who were screened in preventive healthcare settings. All subjects were free of cardiovascular disease and cancer at baseline and completed a maximal exercise stress test. Fitness was categorised into age-specific and sex-specific quintiles according to the treadmill time and dichotomised to low (quintiles 1-2) and high fitness groups. RESULTS:The mean age was 50 ± 8 years and 72% were men. During a median follow-up of 13 years (interquartile range 7-16) 517 (3%) died. Overall, 1455 (7.6%) subjects developed cancer with a median time to cancer diagnosis of 6.4 years (interquartile range 3-10). Death from the time of cancer diagnosis was significantly lower among the high fitness group (Plog rank = 0.03). Time-dependent analysis showed that subjects who developed cancer during follow-up were more likely to die (P < 0.001). The association of cancer with survival was fitness dependent such that in the lower fitness group cancer was associated with a higher risk of death, whereas among the high fitness group the risk of death was lower (hazard ratio 20 vs. 15; Pfor interaction = 0.047). The effect modification persisted after applying a 4-year blanking period between fitness assessment and cancer diagnosis (Pfor interaction = 0.003). CONCLUSION:Higher midlife cardiorespiratory fitness is associated with better survival among cancer patients. Our findings support fitness assessment in preventive healthcare settings.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Fardman A,Banschick GD,Rabia R,Percik R,Fourey D,Segev S,Klempfner R,Grossman E,Maor Edoi
10.1177/2047487320930873subject
Has Abstractpub_date
2020-07-19 00:00:00pages
2047487320930873eissn
2047-4873issn
2047-4881pub_type
杂志文章abstract：BACKGROUND:In clinical practice, individuals at increased risk of cardiovascular diseases (CVD) are identified on the basis of age, sex, smoking, blood pressure, and serum total and high-density lipoprotein cholesterol. We examined whether CVD risk prediction improved when obesity (body mass index ≥30 kg/m(2)) and prem...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312444233
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:There is strong evidence to suggest that social deprivation is linked to health inequalities. In the UK, concerns have been raised regarding disparities in the outcomes of acute cardiac services within the National Health Service (NHS). This study explored whether differences exist in (a) elective hospital p...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:South Asians presenting with chest pain in the UK experience disproportionately greater delays with respect to diagnosis and treatment for acute myocardial infarction (AMI). The duration of time between symptom onset and hospital intervention is a critical delay for AMI but there are limited data amongst Sou...
journal_title：European journal of preventive cardiology
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doi：10.1177/2047487312447844
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Poor adherence to medical treatment represents a major health problem. A subject's misperception of his own cardiovascular risk has been indicated as a key driver for low compliance with preventive measures. This study analysed the relationship between objectively calculated short- and long-term cardiovascul...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487314543074
更新日期：2015-08-01 00:00:00
abstract：:Background This study examined the association between cardiac structure and function and the deterioration in activities of daily living (ADLs) in an age-homogenous, community-dwelling population of patients born in 1920-1921 over a five-year follow-up period. Design Longitudinal cohort study. Methods Patients were r...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317744365
更新日期：2018-02-01 00:00:00
abstract：:Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Metho...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316684054
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Elderly patients are underrepresented in clinical trials but comprise the majority of heart failure patients. Data on age-specific use of heart failure therapy are limited. The European Society of Cardiology heart failure guidelines provide no age-specific treatment recommendations. We investigated practice-...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
abstract：AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711432514
更新日期：2013-02-01 00:00:00
abstract：:Background Patient activity (PA) has been demonstrated to predict all-cause mortality. However, the association between PA and cardiac death is unclear. Aims The aims of this study were to determine whether PA can predict cardiac death and what is the cut-off of PA to discriminate cardiac death, as well as the mechani...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316688982
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:International guidelines recommend pharmacotherapy combinations for chronic coronary syndromes (CCSs) but medical management remains suboptimal. DESIGN:The CICD-LT registry is investigating short- and long-term outcomes and management in patients in European Society of Cardiology (ESC) member countries, in ...
journal_title：European journal of preventive cardiology
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doi：10.1177/2047487320912491
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journal_title：European journal of preventive cardiology
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doi：10.1177/2047487320914115
更新日期：2020-03-31 00:00:00
abstract：BACKGROUND:Cardiac rehabilitation programmes are strongly recommended for all forms of coronary artery disease to reduce recurrent events and mortality. Few patients seem to participate in these programmes after elective percutaneous coronary intervention (PCI). The aim of this study was to assess changes in lifestyle ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312447751
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:To assess the practices of physicians in 12 European countries in the primary prevention of cardiovascular disease (CVD). METHODS:In 2009, 806 physicians from 12 European countries answered a questionnaire, delivered electronically or by post, regarding their assessment of patients with cardiovascular risk ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/1741826711407705
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Exercise oscillatory ventilation is an ominous outcome sign in heart failure due to reduced left ventricular ejection fraction; currently, the prevalence of exercise oscillatory ventilation is unknown in left ventricular assist device recipients. METHODS:We studied cardiopulmonary exercise testing in heart ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487318801415
更新日期：2018-11-01 00:00:00
abstract：AIMS:Exposure to airborne particulate matter has been consistently associated with early death and increased morbidity, particularly raising the risk of cardiovascular disease. Obesity, one of the leading cardiovascular disease risk factors, increases susceptibility to the adverse effects of particulate matter exposure...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487318815320
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:It is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and preva...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320909300
更新日期：2020-03-03 00:00:00
abstract：BACKGROUND:The global coronavirus disease 2019 pandemic has highlighted the importance of understanding the cardiovascular implications of coronavirus infections, with more severe disease in those with cardiovascular co-morbidities, and resulting cardiac manifestations such as myocardial injury, arrhythmias, and heart ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320925965
更新日期：2020-07-01 00:00:00
abstract：:Background There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether physical activity also translates into cardiovascular health benefits in older adults. Therefore, we aimed to c...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317737628
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Several selected population-based studies have emphasized the significance of resting heart rate as an independent cardiovascular risk factor. However, there are no data available for using resting heart rate as a cardiovascular risk predictor in contemporary primary care. Thus, the aim of our analysis was t...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826710394304
更新日期：2012-04-01 00:00:00
abstract：AIMS:To investigate the clinical relevance of contemporary cut-offs of left ventricular ejection fraction (LVEF) including an intermediate phenotype with mid-range reduced ejection fraction among patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND RESULTS:Patient-level data...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319841939
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Identification of individuals at risk for developing atrial fibrillation (AF) will help to target screening and preventive interventions. We aimed to validate the CHARGE-AF model (including variables age, race, height, weight, blood pressure, smoking, antihypertensive medication, diabetes, myocardial infarct...
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doi：10.1177/2047487314544045
更新日期：2015-07-01 00:00:00
abstract：AIMS:The aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques. METHODS:CVD risk was estimated in 210 eligible SLE patients...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
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更新日期：2020-03-02 00:00:00
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journal_title：European journal of preventive cardiology
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doi：10.1177/2047487314562118
更新日期：2016-01-01 00:00:00
abstract：:Background The relationships between dietary intake of soy foods and risk of cardiovascular disease are uncertain. The aims of this study were to evaluate and summarize the evidence on the association between consumption of soy and risk of cardiovascular disease (including stroke and coronary heart disease). Methods W...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487316686441
更新日期：2017-05-01 00:00:00
abstract：:Worldwide, each year more than 7 million people experience myocardial infarction, in which one-year mortality rates are now in the range of 10%, but vary with patient characteristics. The consequences are even more dramatic: among patients who survive, 20% suffer a second cardiovascular event in the first year and app...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487316663873
更新日期：2016-12-01 00:00:00
abstract：:Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487317702044
更新日期：2017-08-01 00:00:00
abstract：AIMS:Prevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population. METHODS AND RESULTS:We report cross-sectional data from the prospective Characteristics and Course o...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320922636
更新日期：2020-05-06 00:00:00
abstract：BACKGROUND:Quadriceps strength is related to exercise capacity in normal subjects and different patient populations, but the relationship between maximal quadriceps isometric strength (QIS) and different exercise capacity levels in coronary artery disease (CAD) patients has not been systematically evaluated yet. METHO...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313492252
更新日期：2014-10-01 00:00:00
abstract：:Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317743355
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Adiponectin is viewed as an insulin-sensitizing hormone with anti-inflammatory effects. In accordance, plasma adiponectin is decreased in metabolic disorders including type 2 diabetes mellitus (T2DM). However, in spite of the apparently beneficially effects, recent data from large prospective studies have co...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313514894
更新日期：2015-03-01 00:00:00
