Biphasic insulin aspart 30: better glycemic control than with premixed human insulin 30 in obese patients with Type 2 diabetes.

Abstract:

AIM:This 3-month study compared the effect on overall glycemic control of adding biphasic insulin aspart 30 (BIAsp30) and premixed human insulin 30/70 (BHI30) to metformin (met) in insulin-naïve, obese patients (30 males/20 females) with Type 2 diabetes (T2DM). MATERIAL/SUBJECTS: At baseline, patients had a mean age of 58.7 yr, glycated hemoglobin (HbA1c) 9.5%, and body mass index 34+/-2 kg/m2. Patients received either twice-daily BIAsp30 (no.=20) or twice-daily BHI30 (no.=30), and continued to receive maximal doses (2000 mg) of met for the duration of the study, but sulphonylurea oral antidiabetic drugs were discontinued. Primary efficacy endpoint was the change in HbA1c in both groups at study end. Safety endpoints included hypoglycemic episodes and weight gain. RESULTS:Both groups reduced HbA1c by end of trial: BIAsp30 + met by 2.5% [2.16-2.86%; 95% confidence interval (CI)]; BHI30 + met by 1.18% (0.98- 1.39%; 95% CI), giving a significantly better HbA1c reduction with BIAsp30 + met (1.33%; p<0.05). Post-prandial plasma glucose decreased in both groups, by 6.38 mmol/l in patients treated with BIAsp30 + met, and by 4.34 mmol/l in those treated with BHI30 + met (p<0.05). Fasting plasma glucose also decreased in both groups, with a slightly larger decrease seen in BIAsp30 patients than in BHI30 patients (7.36 mmol/l at end of study vs 7.82 mmol/l; p=ns). Subjects treated with BIAsp30 gained less weight than those receiving BHI30 (0.3+/-0.1 kg vs 1.2+/-0.4 kg). There was no significant difference in the frequency or number of hypoglycemic episodes between groups. CONCLUSIONS:Adding BIAsp30 to met in obese patients with T2DM results in better glycemic control and less weight gain than adding BHI30.

journal_name

J Endocrinol Invest

authors

Velojic-Golubovic M,Mikic D,Pesic M,Dimic D,Radenkovic S,Antic S

doi

10.1007/BF03345673

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

23-7

issue

1

eissn

0391-4097

issn

1720-8386

pii

6117

journal_volume

32

pub_type

杂志文章
  • Painless thyroiditis developed in a patient with Sheehan's syndrome.

    abstract::We experienced an unusual combination of painless thyroiditis and Sheehan's syndrome in a single patient. A 29-year-old postpartum woman was referred to us for suspected Sheehan's syndrome. Endocrine tests confirmed the diagnosis, but, unexpectedly, her thyroid hormone levels in the plasma were elevated. Based on the ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350313

    authors: Watanobe H,Kawabe H

    更新日期:1997-06-01 00:00:00

  • Impact of overweight and obesity on obstetric outcomes.

    abstract::Abnormal nutritional status is an increasingly common complication in developed countries and, as reproductive age women are a part of this trend, the effect of maternal obesity on the pregnancy and neonate must be investigated. Pregestational obesity or overweight condition or an excessive gestational weight gain can...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0058-9

    authors: Triunfo S,Lanzone A

    更新日期:2014-04-01 00:00:00

  • Assessment of non-traumatic vertebral fractures in Cushing's syndrome patients.

    abstract:PURPOSE:Hypercortisolism has detrimental effects on bone metabolism with the consequences of bone loss and bone fractures. We aimed to evaluate the frequency of vertebral fragility fractures and to determine the factors associated with Cushing's syndrome (CS). METHODS:A total of 135 patients diagnosed with Cushing's s...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01496-y

    authors: Apaydın T,Yavuz DG

    更新日期:2021-01-09 00:00:00

  • Healthy centenarian subjects: the effect of red wine consumption on liver function tests.

    abstract::Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate (

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Pinzani P,Petruzzi E,Orlando C,Malentacchi F,Petruzzi I,Pazzagli M,Masotti G

    更新日期:2005-01-01 00:00:00

  • Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma.

    abstract::Papillary thyroid cancer (PTC) accounts for 80% of all thyroid malignancies, and genetic alterations associated to its etiology remain largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer, providing several candidate genes that need detailed characterization....

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345613

    authors: Hidalgo M,Saez ME,Martinez-Tello FJ,Moron FJ,Ferrero-Herrero E,Labalde-Martinez M,Rigopoulou D,Ballestin-Carcavilla C,Ruiz A,Royo JL,Ramirez-Lorca R

    更新日期:2008-07-01 00:00:00

  • A new test for the diagnosis of growth hormone deficiency due to primary pituitary impairment: combined administration of pyridostigmine and growth hormone-releasing hormone.

    abstract::The diagnosis of growth hormone (GH) deficiency (GHD) is currently based on failure to increase plasma GH levels to an arbitrary cutoff point of 7 or 10 micrograms/l in response to two provocative stimuli. False negative responses to these tests, however, frequently occur thus reducing their diagnostic reliability. Th...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349569

    authors: Ghigo E,Imperiale E,Boffano GM,Mazza E,Bellone J,Arvat E,Procopio M,Goffi S,Barreca A,Chiabotto P

    更新日期:1990-04-01 00:00:00

  • The relationship between body composition and muscle power output in men and women with obesity.

    abstract::In order to investigate the effect of gender, age and level of obesity on body composition and anaerobic power output, and to test the hypothesis that variation in body composition affects muscle power output in obesity, a cohort of 377 subjects (112 males and 265 females, aged 18-75 yr) with different levels of obesi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346280

    authors: Lafortuna CL,Agosti F,Marinone PG,Marazzi N,Sartorio A

    更新日期:2004-10-01 00:00:00

  • Thyroid function evaluation by different commercially available free thyroid hormone measurement kits in term pregnant women and their newborns.

    abstract::Evaluation of thyroid status by measurement of free thyroid hormone concentrations seems particularly helpful in conditions with altered serum binding proteins. In pregnancy, a condition of increased thyroxine binding globulin, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations have been reporte...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350244

    authors: Roti E,Gardini E,Minelli R,Bianconi L,Flisi M

    更新日期:1991-01-01 00:00:00

  • Comparison of circulating and local adipose tissue renin-angiotensin system in normotensive and hypertensive obese subjects.

    abstract::The renin-angiotensin-aldosterone system (RAAS) plays a well-recognized role in the regulation of BP and in salt and water balance. Since hypertension affects a considerable proportion of obese patients, circulating RAAS has been studied in obese subjects with and without hypertension, albeit with conflicting results....

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344010

    authors: Faloia E,Gatti C,Camilloni MA,Mariniello B,Sardu C,Garrapa GG,Mantero F,Giacchetti G

    更新日期:2002-04-01 00:00:00

  • Abnormal development of the sella turcica and lack of pituitary visualization in a patient with partial hypopituitarism.

    abstract::We report the case of a 17-year-old girl presenting short stature (height 149 cm, below the 3rd percentile), obesity (weight 83.5 kg, body mass index 37 kg/m2) and secondary amenorrhea, in whom endocrinological evaluation disclosed an absolute lack of GH responsiveness to both suprapituitary challenges and repetitive ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347844

    authors: Scacchi M,Alé G,Silvestri P,Cavagnini F

    更新日期:1995-05-01 00:00:00

  • Growth of a microprolactinoma to a macroprolactinoma during estrogen therapy.

    abstract::Following presentation and diagnosis, microprolactinomas usually follow a benign course and rarely progress to macroprolactinomas. However, clinically significant enlargement of prolactinomas during pregnancy, presumably related to estrogen stimulation, has been reported. This report describes a patient with amenorrhe...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349744

    authors: Garcia MM,Kapcala LP

    更新日期:1995-06-01 00:00:00

  • Plasma and urine cyclic nucleotide levels in patients with hyperthyroidism and hypothyroidism.

    abstract::Plasma levels and 24-h urinary excretion of cyclic AMP and cyclic GMP were measured in 18 patients with hyperthyroidism, 7 patients with hypothyroidism and 25 normal subjects. Mean plasma and urinary levels of both cyclic AMP and cyclic GMP were significantly positive correlations between the serum thyroid hormone lev...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350603

    authors: Peracchi M,Bamonti-Catena F,Lombardi L,Reschini E,Toschi V,Maiolo AT,Polli EE

    更新日期:1983-06-01 00:00:00

  • Reduced serum thyroglobulin response to bovine TSH in malignant hypofunctioning solid thyroid nodules: comparison to benign nodular disease.

    abstract::Forty-three euthyroid patients with a single, solid, nonfunctioning thyroid nodule were submitted to fine needle aspiration biopsy and serum thyroglobulin (Tg) was measured before and after (48h) 10 U of bovine TSH. Twenty-two normal subjects were also submitted to the bTSH test. Patients with nonfunctioning nodules w...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348125

    authors: Leite Z,Carneiro P,Halpern A,Medeiros-Neto G

    更新日期:1987-06-01 00:00:00

  • Circulating endogenous digitalis-like factor(s) (EDLF) in man is derived from the adrenals and its secretion is ACTH-dependent.

    abstract::Adrenal origin and ACTH-dependent secretion of endogenous digitalis-like factor(s) (EDLF) was investigated. Twelve normal weight normotensive subjects (normal group) and 10 patients with Addison's disease (Addison group) were subjected to prolonged ACTH stimulation with 1 mg tetracosactin-depot im. Blood sampling was ...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347027

    authors: Sophocleous A,Elmatzoglou I,Souvatzoglou A

    更新日期:2003-07-01 00:00:00

  • Presence of endothelin-1 in the normal and pathological human thyroid.

    abstract::An immunohistochemical study with two rabbit polyclonal antibodies I-AR76 and CA-08-351 against Endothelin-1 (ET-1) was performed in 133 human thyroid specimens: 5 normal thyroids, 30 multinodular goiters (15 toxic and 15 nontoxic), 20 Graves' diseases, 5 Hashimoto's thyroiditis, 26 adenomas (6 Hürthle cell, 16 toxic ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347834

    authors: Lenziardi M,Viacava P,Fiorini I,Castagna M,Nardini V,Pollina L,De Negri F,Goletti O,Di Coscio G,Bevilacqua G

    更新日期:1995-05-01 00:00:00

  • The combined effect of adiposity, fat distribution and age on cardiovascular risk factors and motor disability in a cohort of obese women (aged 18-83).

    abstract::Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349195

    authors: Lafortuna CL,Agosti F,Proietti M,Adorni F,Sartorio A

    更新日期:2006-11-01 00:00:00

  • Hypoxia inducible factor-1α gene polymorphisms in Korean patients with pre-eclampsia.

    abstract:BACKGROUND:Placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. Hypoxia inducible factor-1α (HIF-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. AIM:We determined whether maternal blood c.1722C>T (Pro582Ser) and c.1790G>A (Ala...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8009

    authors: Kim SY,Park SY,Lim JH,Lee BY,Yang JH,Ryu HM

    更新日期:2012-07-01 00:00:00

  • Dynamic investigation for evaluation of calcium metabolism and parathyroid function.

    abstract::Differently from other metabolic conditions, most of calcium metabolism disorders are diagnosed through simple detection of both serum and urinary excretion (24-h urine collection), levels of calcium, total and ionized form, and phosphate, and of calciotropic hormone serum levels, such as calcitonin, PTH and vitamin D...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Cioppi F,Falchetti A,Masi L,Brandi ML

    更新日期:2003-01-01 00:00:00

  • Effects of naloxone on adrenal cortex regulation in patients with primary aldosteronism.

    abstract::Excess production of proopiomelanocortin (POMC)-derived peptides with aldosterone-stimulating activity has been suggested to play a pathogenetic role in idiopathic hyperaldosteronism (IHA). To further investigate this issue, the opiate receptor antagonist naloxone was administered to 14 patients with primary aldostero...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350149

    authors: Fallo F,Boscaro M,Sonino N,Mantero F

    更新日期:1988-04-01 00:00:00

  • Use of granulosa-luteal cell culture to evaluate low and high clinical responses to menotropin stimulation.

    abstract::The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344926

    authors: Hurst BS,Zacur HA,Schlaff WD,Berkovitz GD

    更新日期:1992-09-01 00:00:00

  • A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear triiodothyronine receptors.

    abstract::A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; ho...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349636

    authors: Jaffiol C,Baldet L,Torresani J,Bismuth J,Papachristou C

    更新日期:1990-11-01 00:00:00

  • Development of diabetic nephropathy in nude mice.

    abstract:BACKGROUND:Immune dysfunction is very common in diabetes mellitus (DM). However, there is no evidence whether such immune dysfunction can influence the development of DM, especially the development of diabetic nephropathy (DN). AIM:To investigate the influence of absence of T cells on DN. MATERIALS AND METHODS:Balb/c...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8962

    authors: Lin S,Xu PC,Huang QE,Jia JY,Jia ZH,Wei L,Zheng ZF,Shang WY

    更新日期:2013-12-01 00:00:00

  • Postnatal development of pituitary-thyroid function in male and female rats: comparison of plasma and thyroid T3 and T4 concentration.

    abstract::Plasma T4, T3, and TSH, and total and 131l-labeled T4 and T3 in thyroid digests were determined in male and female rats from birth to 30--45 days postnatally. Mothers and offspring were fed a high-iodine Purina diet throughout. In both sexes, plasma T4 was less than 1 microgram/100ml at birth but rose linearly to a pe...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350975

    authors: Fukuda H,Greer MA

    更新日期:1978-10-01 00:00:00

  • Human insulin-specific immunoglobulin G antibody and hypoglycemic attacks after the injection of gold thioglucose.

    abstract::A 56-year-old woman with granulomas of gold thioglucose in her hips exhibited recurrent bouts of hypoglycemic attacks. The first attack occurred 2 years after the last injection of gold thioglucose, when large amounts of extractable insulin and human insulin-specific antibody were noted in her serum. Histological exam...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348654

    authors: Yao K,Uchigata Y,Kyono H,Yokoyama H,Eguchi Y,Fukushima H,Yamauchi K,Hirata Y

    更新日期:1992-01-01 00:00:00

  • New achievement and novel therapeutic applications of PDE5 inhibithors in older males.

    abstract::Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Frajese GV,Pozzi F

    更新日期:2005-01-01 00:00:00

  • Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.

    abstract::The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-017-0732-9

    authors: Piaggi P,Vinales KL,Basolo A,Santini F,Krakoff J

    更新日期:2018-01-01 00:00:00

  • Growth and final height in classical and nonclassical 21-hydroxylase deficiency.

    abstract::Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:

    authors: New MI,Gertner JM,Speiser PW,Del Balzo P

    更新日期:1989-01-01 00:00:00

  • Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats.

    abstract:INTRODUCTION:Vitamin D (VD) insufficiency has been repeatedly observed in the medical conditions associated with inflammation, such as cardiovascular disease, diabetes and depression. However, contrasting to the observational evidence, randomized trials of VD supplementation failed to demonstrate such link. Given the r...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0191-5

    authors: Jiang P,Zhang L,Zhu W,Li H,Dang R,Tang M

    更新日期:2014-11-01 00:00:00

  • Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.

    abstract:PURPOSE:The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters. METHODS:Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution wit...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0100-y

    authors: Unüvar T,Anık A,Catlı G,Esen I,Abacı A,Büyükgebiz A,Böber E

    更新日期:2014-09-01 00:00:00

  • Estrogenic suppression by different administration schedules of goserelin depot for treatment of endometriosis.

    abstract::Eighteen patients affected by laparoscopically confirmed endometriosis were randomly assigned to three different schedules of treatment with gonadotropin-releasing hormone agonist (GnRH-a) (goserelin depot formulation 3.6 mg) every 28 days for 6 months. Six women received the first implant in early follicular phase, 4...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03348925

    authors: Magini A,Pellegrini S,Tavella K,Forti G,Massi GB,Serio M

    更新日期:1993-11-01 00:00:00