Abstract：
:The long-term consequences of transient neonatal hypoglycemia are sparsely studied. We performed a follow-up of a cohort of neonates with blood glucose recordings < 1.7 mmol/L (< 30 mg/dL), treated with > 2.5 mmol/L (> 45 mg/dL), compared with healthy siblings. Exclusion criteria were gestational age < 35 weeks, severe asphyxia, head injury, and other cerebral diseases. In 71 children with neonatal hypoglycemia and 32 control siblings, Wechsler IV cognitive test, Movement ABC-2 test, and Child Behavior Checklist were performed at mean age 7.75 and 9.17 years, respectively. No significant changes were detected for cognitive function by using Wechsler IV or for behavior by using Child Behavior Checklist. In univariate analysis, the hypoglycemia group had lower age-adjusted fine motor scores by using the Movement ABC-2 test compared with control siblings, 42.6 ± 31.2 vs. 57.2 ± 30.8 percentile (p = 0.03). In the sibling-paired analysis, the decrease in total motor score was highly significant, p = 0.009, driven by a decrease in fine motor score, p = 0.008. In the hypoglycemia group, adjusted analysis showed a lower fine motor function for boys, β = - 16.4, p = 0.048.Conclusion: Neonatal hypoglycemia treated with > 2.5 mmol/L was associated with lower fine motor scores within the normal range, particularly in boys. No associations with cognitive function or behavior were detected. What is Known: • Transient neonatal hypoglycemia is associated with acute neurologic dysfunction and long-term neurodevelopment impairment in 18 months of age. What is New: • Neonatal hypoglycemia treated with > 2.5 mmol/L is associated with lower fine motor function within the normal range, particularly in boys, but not to changes in cognitive function or behavior.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Rasmussen AH,Wehberg S,Pørtner F,Larsen AM,Filipsen K,Christesen HTdoi
10.1007/s00431-020-03729-xsubject
Has Abstractpub_date
2020-12-01 00:00:00pages
1981-1991issue
12eissn
0340-6199issn
1432-1076pii
10.1007/s00431-020-03729-xjournal_volume
179pub_type
杂志文章abstract：UNLABELLED:Our aim was to evaluate effectiveness of pandemic influenza A/H1N1 vaccine in preventing acute otitis media (AOM) and/or otitis media with effusion (OME), in a randomized, prospective and single-blind study conducted in the children aged of 6-60 months. This study was done between December 1, 2009 and April ...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-012-1797-2
更新日期：2012-11-01 00:00:00
abstract：:Of all newborn infants, 5% require some degree of basic life support at birth. Newborn resuscitation therefore is one of the most frequent procedures carried out in medicine. It is therefore important that the routines in use are evidence based. Newborn resuscitation can be divided into ten steps: (1) initial stabilis...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014284
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:Population modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the drug will be used clinically. DISCUSSION:The advantages of these models in paediatric studies are that they can be used to analyse sparse data, sam...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-006-0188-y
更新日期：2006-11-01 00:00:00
abstract：:This parallel randomized controlled trial was aimed to evaluate whether parameters as physical fitness, reaction times, self-perception and enjoyment levels, as well as parental and children perspectives, were affected by active video games in inactive and technologically preoccupied children. Data were collected in a...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-019-03457-x
更新日期：2019-10-01 00:00:00
abstract：UNLABELLED:The effect of different feeding regimens, notably the use of hydrolysed cow's milk formulas, on the development of allergic reactions and the development of cow's milk protein-IgG antibodies is still disputed. We prospectively compared the development of allergic manifestations and cow's milk protein-IgG ant...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02002723
更新日期：1996-04-01 00:00:00
abstract：INTRODUCTION:Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis. DISCUSSION:The simultaneous occurrence of met...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-009-0952-x
更新日期：2009-07-01 00:00:00
abstract：:Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population-based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03955-x
更新日期：2021-01-20 00:00:00
abstract：UNLABELLED:Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the...
journal_title：European journal of pediatrics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00431-011-1670-8
更新日期：2012-07-01 00:00:00
abstract：:Twenty-eight children whose parents reported sleep apnoea were investigated. In 15 infants apnoeic periods during sleep could be confirmed during clinical observation. Ventilatory responses to CO2 were measured in all infants, in 23 during sleep in 5 only when awake. A very wide range of CO2 sensitivities was found. I...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496030
更新日期：1986-04-01 00:00:00
abstract：:In a German pediatric oncology unit, the attending physicians diagnosed 27 cases of Clostridium difficile-associated disease (CDI) from January 01, 2010 to October 31, 2013. This refers to a CDI incidence density of 2.0/1000 inpatient days. According to the hospital hygiene standard, symptomatic patients with CDI were...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-3070-1
更新日期：2018-03-01 00:00:00
abstract：UNLABELLED:The objective of this study was to describe the characteristics of children who required mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) support for respiratory syncytial virus (RSV) bronchiolitis, and to identify risk factors associated with disease severity assessed by duration of...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1580-0
更新日期：2005-02-01 00:00:00
abstract：:Twin-to-twin transfusion (TTT) is a complication of monochorionic twins that may result in high mortality and morbidity. To better understand pathophysiology in TTT and the consequences for affected fetuses and neonates, we describe the clinical features of 19 consecutive pregnancies complicated by TTT over 5 years. T...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-002-1107-5
更新日期：2003-02-01 00:00:00
abstract：:Small for gestational age (SGA) infants are known to develop relatively mild transient hyperbilirubinaemia, especially in comparison with premature infants. This may be interpreted as an index of accelerated maturation of particular vital functions. In the present study 12 SGA infants, 12 appropriate for gestational a...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442433
更新日期：1979-11-01 00:00:00
abstract：UNLABELLED:Patients with glycogen storage disease type 1b (GSD1b) not only show hepatomegaly, hypoglycaemia and lactic acidosis, but also neutropenia and neutrophil dysfunction. Here, we report improvement of neutropenia and neutrophil function in a 22-year-old male GSD1b patient who had undergone living-related partia...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1405-1
更新日期：2004-04-01 00:00:00
abstract：:Retrospective analysis was performed at an affiliated university children's hospital with consecutive patients receiving a venoarterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock from July 2007 to May 2018. Fifty-six patients underwent VA-ECMO for refractory cardiogenic shock with t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03352-5
更新日期：2019-06-01 00:00:00
abstract：:Three infants with severe combined immunodeficiency and adenosine deaminase (ADA) deficiency were treated by T-cell depleted bone marrow transplantation (BMT), using human leukocyte antigen (HLA)-haploidentical parents as donors. In the first patient, two initial transplants failed to engraft and no change of the immu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01995857
更新日期：1989-11-01 00:00:00
abstract：:Female patients with congenital adrenal hyperplasia have been frequently studied in order to determine the impact of prenatal androgen exposure on various aspects of psychological, psychosocial and psychosexual development. There is no published study to evaluate the impact of the genital malformation, genital operati...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02276713
更新日期：1995-09-01 00:00:00
abstract：:Bone health is extremely important in early childhood because children with low bone mineral density (BMD) are at a greater risk of bone fractures. While physical activity and intake of both calcium and vitamin D benefit BMD in older children, there is limited research on the determinants of good bone health in early ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03465-x
更新日期：2020-01-01 00:00:00
abstract：:This study was conducted to assess the clinical spectrum, management, and outcome of SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C). We reviewed medical records of children with MIS-C diagnosis seen at the Children's Hospital of Michigan in Detroit between April and June 2020. Thirty-three ch...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-021-03935-1
更新日期：2021-01-16 00:00:00
abstract：:Pseudohyperkalaemia was observed in 3 of 16 patients with Kawasaki disease showing remarkably increased platelet counts. Their plasma potassium concentration, which is not affected by in vitro coagulation, was in the normal range despite the increased serum level. A significant correlation was observed between the pla...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957752
更新日期：1992-07-01 00:00:00
abstract：:In a prospective study elastase alpha 1-proteinase inhibitor (E alpha 1PI), polymorphonuclear (PMN) count, the immature to total neutrophil count ratio (I/T ratio), and C-reactive protein (CRP) were analysed in 74 patients (76 cases) with neonatal septicaemia at the time of initial clinical symptoms. At that early sta...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02113257
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) infected children treated with highly active antiretroviral therapy (HAART) may develop a significant reduction of plasma viremia associated with an increase in CD4+ T-cell counts. Functional capacity of this reconstituted immune system in response to recall antige...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0184-2
更新日期：2007-01-01 00:00:00
abstract：UNLABELLED:Convincing evidence of moderate hyperhomocysteinaemia as a risk factor for vascular disease has accumulated within the last decade being independent of conventional risk factors and equally strong as hypercholesterolaemia and smoking. A synergistic interaction with hypertension and smoking in their joint art...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/pl00014292
更新日期：1998-04-01 00:00:00
abstract：UNLABELLED:Aminoglycoside prescriptions were rarely evaluated in children care facilities. Because of risk of toxicity, these narrow spectrum antibiotics are commonly misused. In this study, we evaluate aminoglycoside prescription and assess the impact of an information campaign on modalities of prescription and monito...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-016-2691-0
更新日期：2016-05-01 00:00:00
abstract：:Total serum LDH activity and isoenzyme distribution were studied in children with neuroblastoma at the time of hospital admission. The total LDH was determined in 26 cases, and 20 (77%) of them showed elevation of its activity. On the other hand, in 9 of these 26 cases, the isoenzyme distribution was determined along ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442638
更新日期：1976-09-01 00:00:00
abstract：UNLABELLED:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive disorder in which haemolytic anaemia is the major symptom. The Beutler spot test employed in mass-screening for galactosaemia in newborns requires several intrinsic erythrocyte enzymes such as G6PD for its reaction and can theoretic...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310000652
更新日期：2001-02-01 00:00:00
abstract：:Phenobarbital has been shown to offer effective prophylaxis against childhood febrile convulsions. However, a high percentage of children do not tolerate phenobarbital, mainly due to behavioral changes. Valproate, due to its low toxicity, appears to be an attractive alternative to phenobarbital treatment. Ninety child...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441308
更新日期：1981-10-01 00:00:00
abstract：UNLABELLED:Atypical hemolytic uremic syndrome (HUS) refers to the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury in the absence of Shiga toxin-producing Escherichia coli exposure or Streptococcus pneumoniae infection. Currently, approximately 50 % of the atypical cases have demons...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-012-1763-z
更新日期：2012-10-01 00:00:00
abstract：UNLABELLED:Administration of human growth hormone (GH) has yielded conflicting results concerning its role on thyroid function in patients with Ullrich-Turner syndrome. Therefore, we investigated the course of thyroid hormone parameters and thyroxin binding globulin in relation to GH therapy, IGF-I and additional oxand...
journal_title：European journal of pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004310050563
更新日期：1997-02-01 00:00:00
abstract：:A 16-year-old girl is described with abetalipoproteinaemia who underwent liver transplantation for hepatic cirrhosis. After this procedure her serum lipoprotein profile was corrected; however, fat malabsorption and steatorrhea persisted because the primary defect, a mutant microsomal triglyceride-transfer protein, rem...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050882
更新日期：1998-07-01 00:00:00
