Granulocyte transfusions in recovery of neutropenic rats from induced E. coli toxicemia.

Abstract:

:Rats made transiently neutropenic by intra-arterial administration of vinblastine (3 mg/kg) and infected with E. coli (6.02+/-0.45 X 10(8), per animal) have a mortality rate of 90% within 48 h post infection. Multiple transfusions of large numbers of granulocytes (harvested from Deca-Durabolin treated donor rats) protected the neutropenic animals from sepsis. Out of a group of 11 rats, 10 recovered completely after repeated granulocyte transfusions.

journal_name

Exp Hematol

journal_title

Experimental hematology

authors

Popovic V,Schaffer R,Popovic P

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

166-70

issue

3

eissn

0301-472X

issn

1873-2399

journal_volume

5

pub_type

杂志文章
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    journal_title:Experimental hematology

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    doi:

    authors: Stebler C,Tichelli A,Dazzi H,Gratwohl A,Nissen C,Speck B

    更新日期:1990-12-01 00:00:00

  • Identification of CD34+ subsets after glycoprotease selection: engraftment of CD34+Thy-1+Lin- stem cells in fetal sheep.

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    journal_title:Experimental hematology

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    doi:

    authors: Sutherland DR,Yeo EL,Stewart AK,Nayar R,DiGiusto R,Zanjani E,Hoffman R,Murray LJ

    更新日期:1996-06-01 00:00:00

  • A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid precursor cells in vitro. IV. Properties and developmental relationships of the lymphoid cells in the adherent and nonadherent compartments of the culture.

    abstract::In a selective culture system, the in vitro generation of terminal deoxynucleotidyl transferase positive (TdT+) B cell progenitors from rat, mouse, and human bone marrow (BM) is characterized by initial lymphoid colonization of a mouse BM feeder layer. In the present study, four sequentially appearing subsets of B cel...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: McKenna SD,Medlock ES,Greiner DL,Goldschneider I

    更新日期:1994-11-01 00:00:00

  • The fate of blood granulocytes.

    abstract::The present study was undertaken to determine whether neutrophilic granulocytes leave the vascular bed and enter body tissues, particularly the lung, in pathogen-free mice under normal steady state conditions and also under inflammatory stress. Tissues from normal mice and from mice with granulocytosis-producing tumor...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Jamuar MP,Cronkite EP

    更新日期:1980-08-01 00:00:00

  • Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation.

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    journal_title:Experimental hematology

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    doi:10.1016/j.exphem.2015.08.010

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    更新日期:2016-01-01 00:00:00

  • Thalidomide maintenance therapy maturates the T cell compartment and compromises antigen-specific antitumor immunity in patients with multiple myeloma.

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    doi:10.1016/j.exphem.2012.10.018

    authors: Herth I,Witzens-Harig M,Beckhove P,Hose D,Meissner T,Neuber B,Engelhardt M,Haas J,Neben K,Ho AD,Klein B,Goldschmidt H,Hundemer M

    更新日期:2013-03-01 00:00:00

  • Activity of the caspase-3/CPP32 enzyme is increased in "early stage" myelodysplastic syndromes with excessive apoptosis, but caspase inhibition does not enhance colony formation in vitro.

    abstract:OBJECTIVE:Excessive apoptosis may have a role in the ineffective hematopoiesis and cytopenias observed in myelodysplastic syndromes. The goals of this study were 1) to quantify apoptosis in patients with "early stage" myelodysplasia [including patients with refractory anemia (RA), RA with ringed sideroblasts (RARS), RA...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/s0301-472x(00)00179-x

    authors: Bouscary D,Chen YL,Guesnu M,Picard F,Viguier F,Lacombe C,Dreyfus F,Fontenay-Roupie M

    更新日期:2000-07-01 00:00:00

  • Adeno-associated virus 2-mediated gene transfer and functional expression of the human granulocyte-macrophage colony-stimulating factor.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Luo F,Zhou SZ,Cooper S,Munshi NC,Boswell HS,Broxmeyer HE,Srivastava A

    更新日期:1995-11-01 00:00:00

  • KBM-3, an in vitro model of human acute myelomonocytic leukemia.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Andersson BS,Bergerheim US,Collins VP,Childs C,Beran M,Sen S,Arden K,Pathak S,Siciliano MJ,Ost A

    更新日期:1992-03-01 00:00:00

  • Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2018.12.007

    authors: Simic D,Sang N

    更新日期:2019-04-01 00:00:00

  • Stimulation and priming of human neutrophils by IL-1 alpha and IL-1 beta: complete inhibition by IL-1 receptor antagonist and no interaction with other cytokines.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Yagisawa M,Yuo A,Kitagawa S,Yazaki Y,Togawa A,Takaku F

    更新日期:1995-07-01 00:00:00

  • Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo.

    abstract:OBJECTIVE:Differentiation-inducing therapy by agents such as 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) represents a useful approach for the treatment of acute myelogenous leukemia (AML). We previously showed that Gemini-23-yne-26,27-hexafluoro-D(3) inhibited the proliferation of MCF-7 breast cancer cells in associat...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/j.exphem.2010.03.020

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    更新日期:2010-08-01 00:00:00

  • Fully and long-term xenogeneic hematopoietic chimeras created in poorly concordant rat-mouse combinations: expression of hereditary donor characteristics.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Spach C,Lucchiari N,Bureaud N,Motta R

    更新日期:1995-10-01 00:00:00

  • Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes.

    abstract::Megakaryocytic differentiation of progenitor cells was investigated in nine patients with low-risk myelodysplastic syndromes (MDS) (eight refractor anemia [RA] and one RA with ringed sideroblasts [RARS] and five patients with high-risk MDS (two RA with excess of blasts [RAEB] and three RAEB in transformation [RAEB-T])...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/s0301-472x(98)00077-0

    authors: Hofmann WK,Kalina U,Wagner S,Seipelt G,Ries C,Hoelzer D,Ottmann OG

    更新日期:1999-03-01 00:00:00

  • Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells.

    abstract::The present studies evaluated effects of recombinant human (rhu) and murine (rmu) flt3 ligand (flt3-L) on colony formation by subsets of myeloid stem and progenitor cells present in low-density (LD) and cell-sorted CD34 hu cord blood (CB) and bone marrow (BM) cells and unseparated mu BM cells. By itself, flt3-L had we...

    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Broxmeyer HE,Lu L,Cooper S,Ruggieri L,Li ZH,Lyman SD

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  • Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:10.1016/s0301-472x(03)00042-0

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    更新日期:2003-05-01 00:00:00

  • HIV-associated lymphoma successfully treated with peripheral blood stem cell transplantation.

    abstract:OBJECTIVE:To evaluate feasibility, safety, and efficacy of peripheral blood stem cell collection (PBSCC) and autologous stem cell transplantation (ASCT), to treat patients diagnosed of high-risk or relapsed HIV-associated lymphoma (HIV+ Ly), responding to highly active antiretroviral therapy (HAART). METHODS:Prospecti...

    journal_title:Experimental hematology

    pub_type: 临床试验,杂志文章,多中心研究

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    更新日期:2005-04-01 00:00:00

  • Additive effect of PTK787/ZK 222584, a potent inhibitor of VEGFR phosphorylation, with Idarubicin in the treatment of acute myeloid leukemia.

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    pub_type: 杂志文章

    doi:10.1016/j.exphem.2009.03.001

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  • 60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.

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    abstract::In this study, we have used the sublethally irradiated rat as a model to examine the relationship between platelet count and the plasma level of megakaryocyte growth-promoting activity (Meg-GPA) assayed in vitro. Meg-GPA of irradiated rats whose platelet counts were maintained by platelet transfusions was compared to ...

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    pub_type: 杂志文章

    doi:

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    更新日期:1988-02-01 00:00:00

  • Purification and amino acid analysis of a human macrophage cytotoxicity-inducing factor (MCF).

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    pub_type: 杂志文章

    doi:

    authors: Jones CM,Prince CA,Williams JS

    更新日期:1991-08-01 00:00:00

  • Assessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Gothot A,Pyatt R,McMahel J,Rice S,Srour EF

    更新日期:1998-07-01 00:00:00

  • Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation.

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Jordan CT,Astle CM,Zawadzki J,Mackarehtschian K,Lemischka IR,Harrison DE

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  • Alterations in erythropoiesis in TGF-beta 1-treated mice.

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    pub_type: 杂志文章

    doi:

    authors: Miller KL,Carlino JA,Ogawa Y,Avis PD,Carroll KG

    更新日期:1992-09-01 00:00:00

  • Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+).

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    pub_type: 杂志文章

    doi:

    authors: Weimar IS,Miranda N,Muller EJ,Hekman A,Kerst JM,de Gast GC,Gerritsen WR

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  • Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery.

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    更新日期:2009-01-01 00:00:00

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    journal_title:Experimental hematology

    pub_type: 杂志文章

    doi:

    authors: Oskéritzian C,Le Mao J,David B

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  • Beyond "to divide or not to divide": Kinetics matters in hematopoietic stem cells.

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    pub_type: 杂志文章

    doi:

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    更新日期:1995-03-01 00:00:00