Applications of cell-free circulating tumor DNA detection in EGFR mutant lung cancer.

Abstract:

:Analyses of cell-free tumor DNA (ctDNA) have provided a non-invasive strategy for cancer diagnosis, the identification of molecular aberrations for treatment identification, and evaluation of tumor response. Sensitive and specific ctDNA sequencing strategies have allowed for implementation into clinical practice for the initial genotyping of patients and resistance monitoring. The specific need for EGFR mutation detection for the management of lung cancer patients has been an early imperative and has set the stage for non-invasive molecular profiling across other oncogenic drivers. Ongoing efforts are demonstrating the utility of ctDNA analyses in the initial genotyping of patients, the monitoring resistance clones, and the initial evaluation of response.

journal_name

J Thorac Dis

authors

Bulbul A,Leal A,Husain H

doi

10.21037/jtd.2020.01.66

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

2877-2882

issue

5

eissn

2072-1439

issn

2077-6624

pii

jtd-12-05-2877

journal_volume

12

pub_type

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