Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis.

Abstract:

BACKGROUND:Published studies present conflicting data regarding the impact of Thrombospondin-1 (TSP-1) expression on prognosis of various cancers. We performed this meta-analysis to illustrate the preliminary predictive value of TSP-1. METHODS:Twenty-four studies with a total of 2379 patients were included. A comprehensive literature search was performed by using PubMed, Cochrane Library, Web of Science, Embase, and hand searches were also conducted of relevant bibliographies. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for patient survival and disease recurrence were initially identified to explore relationships between TSP-1 expression and patient prognosis. RESULTS:A total of 24 eligible studies were included in this meta-analysis. Our results showed that high level of TSP-1 was correlated significantly with poor overall survival (OS) (HR = 1.40, 95% CI: 1.17 ~ 1.68; P<0.001). However, high TSP-1 expression predicted no significant impact on progression-free survival (PFS)/ metastasis-free survival (MFS) (HR = 1.35, 95%CI: 0.87-2.10; P = 0.176) and disease-free survival (DFS)/ recurrence-free survival (RFS) (HR = 1.40, 95%CI: 0.77-2.53; P = 0.271). In addition, we performed subgroup analyses which showed that high TSP-1 expression predicted poor prognosis in breast cancer and gynecological cancer. Additionally, the relatively small number of studies on PFS/MFS and DFS/RFS is a limitation. The data extracted through Kaplan-Meier curves may not be accurate. Moreover, only English articles were included in this article, which may lead to deviations in the results. CONCLUSIONS:Our findings indicated high TSP-1 expression may act as a promising biomarker of poor prognosis in cancers, especially in breast cancer and gynecological cancer.

journal_name

BMC Med Genet

journal_title

BMC medical genetics

authors

Sun S,Dong H,Yan T,Li J,Liu B,Shao P,Li J,Liang C

doi

10.1186/s12881-020-01073-3

subject

Has Abstract

pub_date

2020-06-29 00:00:00

pages

139

issue

1

issn

1471-2350

pii

10.1186/s12881-020-01073-3

journal_volume

21

pub_type

杂志文章,meta分析
  • Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations.

    abstract:BACKGROUND:The SDHD gene encodes a subunit of the mitochondrial tricarboxylic acid cycle enzyme and tumor suppressor, succinate dehydrogenase. Mutations in this gene show a remarkable pattern of parent-of-origin related tumorigenesis, with almost all SDHD-related cases of head and neck paragangliomas and pheochromocyto...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-014-0111-8

    authors: Bayley JP,Oldenburg RA,Nuk J,Hoekstra AS,van der Meer CA,Korpershoek E,McGillivray B,Corssmit EP,Dinjens WN,de Krijger RR,Devilee P,Jansen JC,Hes FJ

    更新日期:2014-10-10 00:00:00

  • FANCM and RECQL genetic variants and breast cancer susceptibility: relevance to South Poland and West Ukraine.

    abstract:BACKGROUND:FANCM and RECQL have recently been reported as breast cancer susceptibility genes and it has been suggested that they should be included on gene panel tests for breast cancer predisposition. However, the clinical value of testing for mutations in RECQL and FANCM remains to be determined. In this study, we ha...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0524-x

    authors: Nguyen-Dumont T,Myszka A,Karpinski P,Sasiadek MM,Akopyan H,Hammet F,Tsimiklis H,Park DJ,Pope BJ,Slezak R,Kitsera N,Siekierzynska A,Southey MC

    更新日期:2018-01-19 00:00:00

  • Eight previously unidentified mutations found in the OA1 ocular albinism gene.

    abstract:BACKGROUND:Ocular albinism type 1 (OA1) is an X-linked ocular disorder characterized by a severe reduction in visual acuity, nystagmus, hypopigmentation of the retinal pigmented epithelium, foveal hypoplasia, macromelanosomes in pigmented skin and eye cells, and misrouting of the optical tracts. This disease is primari...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-7-41

    authors: Mayeur H,Roche O,Vêtu C,Jaliffa C,Marchant D,Dollfus H,Bonneau D,Munier FL,Schorderet DF,Levin AV,Héon E,Sutherland J,Lacombe D,Said E,Mezer E,Kaplan J,Dufier JL,Marsac C,Menasche M,Abitbol M

    更新日期:2006-04-28 00:00:00

  • MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene.

    abstract:BACKGROUND:Mitochondrial DNA (mtDNA) mutations account for at least 5% of cases of postlingual, nonsyndromic hearing impairment. Among them, mutation A1555G is frequently found associated with aminoglycoside-induced and/or nonsyndromic hearing loss in families presenting with extremely variable clinical phenotypes. Bio...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-8-81

    authors: Ballana E,Mercader JM,Fischel-Ghodsian N,Estivill X

    更新日期:2007-12-21 00:00:00

  • Neural network analysis in pharmacogenetics of mood disorders.

    abstract:BACKGROUND:The increasing number of available genotypes for genetic studies in humans requires more advanced techniques of analysis. We previously reported significant univariate associations between gene polymorphisms and antidepressant response in mood disorders. However the combined analysis of multiple gene polymor...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-5-27

    authors: Serretti A,Smeraldi E

    更新日期:2004-12-09 00:00:00

  • Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are important small non-coding RNA molecules that regulate gene expression in cellular processes related to the pathogenesis of cancer. Genetic variation in miRNA genes could impact their synthesis and cellular effects and single nucleotide polymorphisms (SNPs) are one example of genetic v...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-015-0248-0

    authors: Chacon-Cortes D,Smith RA,Haupt LM,Lea RA,Youl PH,Griffiths LR

    更新日期:2015-11-17 00:00:00

  • Factor-V Leiden G1691A and prothrombin G20210A polymorphisms in Sudanese women with preeclampsia, a case -control study.

    abstract:BACKGROUND:Preeclampsia can lead to adverse maternal and perinatal outcomes. There are few studies on the association of preeclampsia with thrombophilia in Africa including Sudan. METHODS:A case -controls study was conducted at Saad Abualila Hospital in Khartoum, Sudan during the period of February through November 20...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0737-z

    authors: Ahmed NA,Adam I,Elzaki SEG,Awooda HA,Hamdan HZ

    更新日期:2019-01-05 00:00:00

  • ADIPOQ single nucleotide polymorphisms and breast cancer in northeastern Mexican women.

    abstract:BACKGROUND:Adiponectin gene (ADIPOQ) polymorphisms have been shown to affect adiponectin serum concentration and some have been associated with breast cancer (BC) risk. The aims of this study were to describe the frequency of single nucleotide polymorphisms (SNPs) of ADIPOQ in Mexican women with BC and to determine if ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01125-8

    authors: Cerda-Flores RM,Camarillo-Cárdenas KP,Gutiérrez-Orozco G,Villarreal-Vela MP,Garza-Guajardo R,Ponce-Camacho MA,Castruita-Ávila AL,González-Guerrero JF,Rodríguez-Sánchez IP,Calderón-Garcidueñas AL,Rodríguez-Gutierrez HF,Arellano-Barr

    更新日期:2020-09-25 00:00:00

  • CNV analysis in 169 patients with bladder exstrophy-epispadias complex.

    abstract:BACKGROUND:The bladder exstrophy-epispadias complex (BEEC) represents the severe end of the congenital uro-rectal malformation spectrum. Initial studies have implicated rare copy number variations (CNVs), including recurrent duplications of chromosomal region 22q11.21, in BEEC etiology. METHODS:To detect further CNVs,...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-016-0299-x

    authors: von Lowtzow C,Hofmann A,Zhang R,Marsch F,Ebert AK,Rösch W,Stein R,Boemers TM,Hirsch K,Marcelis C,Feitz WF,Brusco A,Migone N,Di Grazia M,Moebus S,Nöthen MM,Reutter H,Ludwig M,Draaken M

    更新日期:2016-04-30 00:00:00

  • Circulating leukocyte telomere length is highly heritable among families of Arab descent.

    abstract:BACKGROUND:Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults. It is not known, however, whether or not telomere length is a highly conserved inheritable trait in this homogeneous cohort, where age-related diseas...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-13-38

    authors: Al-Attas OS,Al-Daghri NM,Alokail MS,Alkharfy KM,Alfadda AA,McTernan P,Gibson GC,Sabico SB,Chrousos GP

    更新日期:2012-05-18 00:00:00

  • Neurodegeneration in an adolescent with Sjogren-Larsson syndrome: a decade-long follow-up case report.

    abstract:BACKGROUND:Sjogren-Larsson syndrome is a hereditary neurocutaneous syndrome that is non-progressive in nature. Although neuroregression has been reported in seizure-prone preschool children requiring anti-epileptic treatment, teenage-onset dystonia precipitating neurodegeneration without any immediate causal events has...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0663-0

    authors: Cho KH,Shim SH,Jung Y,Sung SR,Kim M

    更新日期:2018-08-29 00:00:00

  • Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions.

    abstract:BACKGROUND:Neurofibromatosis type-1 (NF1) is caused by mutations of the NF1 gene at 17q11.2. In 95% of non-founder NF1 patients, NF1 mutations are identifiable by means of a comprehensive mutation analysis. 5-10% of these patients harbour microdeletions encompassing the NF1 gene and its flanking regions. NF1 is charact...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-13-98

    authors: Mußotter T,Kluwe L,Högel J,Nguyen R,Cooper DN,Mautner VF,Kehrer-Sawatzki H

    更新日期:2012-10-26 00:00:00

  • Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene.

    abstract:BACKGROUND:DJ-1 forms part of the neuronal cellular defence mechanism against oxidative insults, due to its ability to undergo self-oxidation. Oxidative stress has been implicated in the pathogenesis of central nervous system damage in different neurodegenerative disorders including Alzheimer's disease and Parkinson's ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-10-105

    authors: Keyser RJ,van der Merwe L,Venter M,Kinnear C,Warnich L,Carr J,Bardien S

    更新日期:2009-10-13 00:00:00

  • Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study.

    abstract:BACKGROUND:Crohn's disease (CD) has the highest prevalence among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Caucasian populations (NJ). We evaluated a set of well-established CD-susceptibility variants to determine if they can explain the increased CD risk in the AJ population. METHODS:We recr...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-12-63

    authors: Peter I,Mitchell AA,Ozelius L,Erazo M,Hu J,Doheny D,Abreu MT,Present DH,Ullman T,Benkov K,Korelitz BI,Mayer L,Desnick RJ,New York Crohn's Disease Working Group.

    更新日期:2011-05-06 00:00:00

  • Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease.

    abstract:BACKGROUND:The platelet P2Y12 receptor plays a key role in platelet activation. The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. No data are available on its asso...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-8-59

    authors: Cavallari U,Trabetti E,Malerba G,Biscuola M,Girelli D,Olivieri O,Martinelli N,Angiolillo DJ,Corrocher R,Pignatti PF

    更新日期:2007-09-05 00:00:00

  • The impact of CFNS-causing EFNB1 mutations on ephrin-B1 function.

    abstract:BACKGROUND:Mutations of EFNB1 cause the X-linked malformation syndrome craniofrontonasal syndrome (CFNS). CFNS is characterized by an unusual phenotypic pattern of inheritance, because it affects heterozygous females more severely than hemizygous males. This sex-dependent inheritance has been explained by random X-inac...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-98

    authors: Makarov R,Steiner B,Gucev Z,Tasic V,Wieacker P,Wieland I

    更新日期:2010-06-17 00:00:00

  • Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level.

    abstract:BACKGROUND:E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. METHODS:Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-13-115

    authors: Wu S,Hsu LA,Teng MS,Lin JF,Chang HH,Sun YC,Chen HP,Ko YL

    更新日期:2012-11-29 00:00:00

  • A novel pore-region mutation, c.887G > A (p.G296D) in KCNQ4, causing hearing loss in a Chinese family with autosomal dominant non-syndromic deafness 2.

    abstract:BACKGROUND:Hereditary non-syndromic hearing loss is the most common inherited sensory defect in humans. The KCNQ4 channel belongs to a family of potassium ion channels that play crucial roles in physiology and disease. Mutations in KCNQ4 underlie deafness non-syndromic autosomal dominant 2, a subtype of autosomal domin...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-017-0396-5

    authors: Huang B,Liu Y,Gao X,Xu J,Dai P,Zhu Q,Yuan Y

    更新日期:2017-03-24 00:00:00

  • Gene spectrum analysis of thalassemia for people residing in northern China.

    abstract:BACKGROUND:Southern China provinces have high incidence of thalassemia, however, sporadic cases can be found in northern China as well. METHODS:People resided in north China who were suspected to have thalassemia were detected mutations by gap-polymerase chain reaction (Gap-PCR) and reverse dot blot (RDB) analyses. Th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-019-0818-7

    authors: Yang Z,Zhou W,Cui Q,Qiu L,Han B

    更新日期:2019-05-22 00:00:00

  • Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

    abstract:BACKGROUND:Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease. METHODS:330 SNPs in 52 genes were studied in relation to plasma homocysteine ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-12-150

    authors: Wernimont SM,Clark AG,Stover PJ,Wells MT,Litonjua AA,Weiss ST,Gaziano JM,Tucker KL,Baccarelli A,Schwartz J,Bollati V,Cassano PA

    更新日期:2011-11-21 00:00:00

  • A novel SPAST gene mutation identified in a Chinese family with hereditary spastic paraplegia.

    abstract:BACKGROUND:Hereditary spastic paraplegia is a heterogeneous group of clinically and genetically neurodegenerative diseases characterized by progressive gait disorder. Hereditary spastic paraplegia can be inherited in various ways, and all modes of inheritance are associated with multiple genes or loci. At present, more...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-020-01053-7

    authors: Yu W,Jin H,Deng J,Nan D,Huang Y

    更新日期:2020-06-03 00:00:00

  • Estrogen and progesterone-related gene variants and colorectal cancer risk in women.

    abstract:BACKGROUND:Observational studies and randomized trials have suggested that estrogens and/or progesterone may lower the risk for colorectal cancer. Inherited variation in the sex-hormone genes may be one mechanism by which sex hormones affect colorectal cancer, although data are limited. METHOD:We conducted a comprehen...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-12-78

    authors: Lin JH,Manson JE,Kraft P,Cochrane BB,Gunter MJ,Chlebowski RT,Zhang SM

    更新日期:2011-05-31 00:00:00

  • Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya.

    abstract:BACKGROUND:The relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and clinical phenomena such as primaquine-sensitivity and protection from severe malaria remains poorly defined, with past association studies yielding inconsistent and conflicting results. One possibility is that examination of a s...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-014-0093-6

    authors: Shah SS,Macharia A,Makale J,Uyoga S,Kivinen K,Craik R,Hubbart C,Wellems TE,Rockett KA,Kwiatkowski DP,Williams TN

    更新日期:2014-09-09 00:00:00

  • A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation.

    abstract:BACKGROUND:Cryptic structural abnormalities within the subtelomeric regions of chromosomes have been the focus of much recent research because of their discovery in a percentage of people with mental retardation (UK terminology: learning disability). These studies focused on subjects (largely children) with various sev...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-5-21

    authors: Pickard BS,Hollox EJ,Malloy MP,Porteous DJ,Blackwood DH,Armour JA,Muir WJ

    更新日期:2004-08-13 00:00:00

  • DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

    abstract:BACKGROUND:Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by dif...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-14-76

    authors: Hall E,Dayeh T,Kirkpatrick CL,Wollheim CB,Dekker Nitert M,Ling C

    更新日期:2013-07-23 00:00:00

  • Temple-Baraitser Syndrome and Zimmermann-Laband Syndrome: one clinical entity?

    abstract:BACKGROUND:KCNH1 encodes a voltage-gated potassium channel that is predominantly expressed in the central nervous system. Mutations in this gene were recently found to be responsible for Temple-Baraitser Syndrome (TMBTS) and Zimmermann-Laband syndrome (ZLS). METHODS:Here, we report a new case of TMBTS diagnosed in a L...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-016-0304-4

    authors: Mégarbané A,Al-Ali R,Choucair N,Lek M,Wang E,Ladjimi M,Rose CM,Hobeika R,Macary Y,Temanni R,Jithesh PV,Chouchane A,Sastry KS,Thomas R,Tomei S,Liu W,Marincola FM,MacArthur D,Chouchane L

    更新日期:2016-06-10 00:00:00

  • New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report.

    abstract:BACKGROUND:Osteodysplasia of the oral and maxillofacial bone is generally accompanied by systemic bone abnormalities (such as short stature, joint contracture) or other systemic abnormalities (such as renal, dermatological, cardiovascular, optic, or hearing disorders). However, it does not always present this way. Rece...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-019-0858-z

    authors: Aoyama KI,Kimura M,Yamazaki H,Uchibori M,Kojima R,Osawa Y,Hosomichi K,Ota Y,Tanaka M,Yamada S,Nishimura G

    更新日期:2019-07-16 00:00:00

  • NGS in argininosuccinic aciduria detects a mutation (D145G) which drives alternative splicing of ASL: a case report study.

    abstract:BACKGROUND:Argininosuccinic aciduria (ASAuria; OMIM 207900) is a rare autosomal recessive heterogeneous urea cycle disorder, which leads to the accumulation of argininosuccinic acid in the blood and urine. We aimed to perform genetic test to the patient and help clinician to diagnose precisely. CASE PRESENTATION:In th...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-016-0273-7

    authors: Wen W,Yin D,Huang F,Guo M,Tian T,Zhu H,Yang Y

    更新日期:2016-02-03 00:00:00

  • Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment.

    abstract:BACKGROUND:We evaluated cytogenetic results occurring with first trimester pregnancy loss, and assessed the type and frequency of chromosomal abnormalities after assisted reproductive treatment (ART) and compared them with a control group. We also compared the rate of chromosomal abnormalities according to infertility ...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2350-11-153

    authors: Kim JW,Lee WS,Yoon TK,Seok HH,Cho JH,Kim YS,Lyu SW,Shim SH

    更新日期:2010-11-03 00:00:00

  • Rubinstein-Taybi 2 associated to novel EP300 mutations: deepening the clinical and genetic spectrum.

    abstract:BACKGROUND:Rubinstein-Taybi syndrome (RSTS) is a rare autosomal dominant neurodevelopmental disorder characterized by broad thumbs and halluces. RSTS is caused by mutations in CREBBP and in EP300 genes in 50-60% and 8%, respectively. Up to now, 76 RSTS-EP300 patients have been described. We present the clinical and mol...

    journal_title:BMC medical genetics

    pub_type: 杂志文章

    doi:10.1186/s12881-018-0548-2

    authors: López M,García-Oguiza A,Armstrong J,García-Cobaleda I,García-Miñaur S,Santos-Simarro F,Seidel V,Domínguez-Garrido E

    更新日期:2018-03-05 00:00:00