Abstract:
BACKGROUND:Neuropsychiatric diseases primarily characterized by dementia stand third in the global list of diseases causing disability. The poor water solubility, erratic oral absorption, low bioavailability, poor intestinal absorption, and the impeding action of the blood-brain barrier (BBB) are the major factors limiting the therapeutic feasibility of the antipsychotics. Only a small percentage of antipsychotics reaches the therapeutic target site, which warrants administration of high doses, consequently leading to unwanted side-effects. Hence the main struggle for the effective treatment of neuropsychiatric diseases occurs "at the gates" of the brain, which can be mitigated with the use of a nanotechnology-based platform. METHODS:The goal of this review is to undertake a comprehensive study about the role of lipid nanoformulations in facilitating the delivery of antipsychotics across BBB along with the available in vitro and in vivo evidence. RESULTS:Lipid nanoformulations have attained great popularity for the delivery of therapeutics into the brain. Their nanosize helps in overcoming the biological barriers, thereby providing easy BBB translocation of the drugs. Besides, they offer numerous advantages like controlled and targeted drug release, minimizing drug efflux, long storage stability, augmented bioavailability, and reduced adverse drug effects to attain an optimal therapeutic drug concentration in the brain. Moreover, employing alternative routes of administration has also shown promising results. CONCLUSION:Thus, it can be concluded that the lipid nanoformulations bear immense potential in overcoming the challenges associated with the treatment of neuropsychiatric disorders. However, the area warrants further clinical studies to ensure their commercialization, which could revolutionize the treatment of neuropsychiatric diseases in the coming decades.
journal_name
Curr Drug Metabjournal_title
Current drug metabolismauthors
Rehman S,Nabi B,Pottoo FH,Baboota S,Ali Jdoi
10.2174/1573399816666200627214129subject
Has Abstractpub_date
2020-01-01 00:00:00pages
674-684issue
9eissn
1389-2002issn
1875-5453pii
CDR-EPUB-107703journal_volume
21pub_type
杂志文章abstract::Advances in high-throughput technologies to measure genome-scale changes of genes, proteins, and other biomolecular components ('omics') in complex biological systems have dramatically revolutionized biomedical research. However, the benefits of utilizing omics information in drug development have not yet been fully r...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/138920008786927802
更新日期:2008-12-01 00:00:00
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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doi:10.2174/138920012802138615
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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doi:10.2174/1389200221999210101233340
更新日期:2021-01-01 00:00:00
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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journal_title:Current drug metabolism
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更新日期:2011-09-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2019-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2011-06-01 00:00:00