Abstract:
:This study was performed to evaluate clinical characteristics of branch retinal vein occlusion (BRVO) patients with increased retinal haemorrhage during macular oedema (MO) treatment. Patients were divided into increased and non-increased retinal haemorrhage groups. The former group was sub-divided based on the degree of increase: < 50% or ≥ 50%. Baseline characteristics, clinical data, and best vision achieved before and after increased retinal haemorrhage were assessed. Sixty-eight eyes of 68 patients were included. Forty-six eyes were non-increased, 11 eyes experienced < 50% increase in retinal haemorrhage, and 11 eyes had ≥ 50% increase. Ischaemic BRVO was related to increased haemorrhage based on the multivariate analysis. The ≥ 50% increase group exhibited higher baseline central subfield macular thickness (CSMT), poorer baseline best corrected visual acuity (BCVA), and longer mean periods between the final intravitreal injections and the time increased retinal haemorrhages were observed, compared to the < 50% group. The best vision achieved before and after increased haemorrhage was significantly worse in the ≥ 50% group. In conclusion, the ischaemic type of BRVO is related to increased retinal haemorrhage during MO treatment, and a ≥ 50% increase in haemorrhages is associated with higher CSMT and poorer BCVA at baseline, with poor visual gain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee YH,Kim YCdoi
10.1038/s41598-020-67395-7subject
Has Abstractpub_date
2020-06-24 00:00:00pages
10272issue
1issn
2045-2322pii
10.1038/s41598-020-67395-7journal_volume
10pub_type
杂志文章abstract::Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenvironment remains unclear. We postulated that, in prostate cancer (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39537-z
更新日期:2019-02-28 00:00:00
abstract::BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06915-4
更新日期:2017-07-27 00:00:00
abstract::Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39965-x
更新日期:2019-03-01 00:00:00
abstract::In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02734-9
更新日期:2017-06-14 00:00:00
abstract::Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14675
更新日期:2015-09-30 00:00:00
abstract::The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81515-x
更新日期:2021-01-21 00:00:00
abstract::Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45703-0
更新日期:2019-06-24 00:00:00
abstract::Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36087-8
更新日期:2018-12-12 00:00:00
abstract::It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16658-x
更新日期:2017-11-27 00:00:00
abstract::Glioblastoma (GBM) is the most aggressive brain primary malignancy. Toll-like receptor 4 (TLR4) has a dual role in cell fate, promoting cell survival or death depending on the context. Here, we analyzed TLR4 expression in different grades of astrocytoma, and observed increased expression in tumors, mainly in GBM, comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79356-1
更新日期:2021-01-14 00:00:00
abstract::The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31020
更新日期:2016-08-08 00:00:00
abstract::Patients with scirrhous gastric cancer (SGC) frequently develop peritoneal dissemination, which leads to poor prognosis. The secreted protein angiopoietin-like-4 (ANGPTL4), which is induced by hypoxia, exerts diverse effects on cancer progression. Here, we aimed to determine the biological function of ANGPTL4 in SGC c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11769-x
更新日期:2017-09-11 00:00:00
abstract::The 37 currently recognized Bemisia tabaci cryptic species are economically important species and contain both primary and secondary endosymbionts, but their diversity has never been mapped systematically across the group. To achieve this, PacBio sequencing of full-length bacterial 16S rRNA gene amplicons was carried ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42793-8
更新日期:2019-04-25 00:00:00
abstract::The current standard treatment for ovarian cancer is aggressive surgery followed by platinum-based combination chemotherapy. Recurrence and chemotherapeutic drug resistance are the two main factors that account for the high mortality of most ovarian cancers. Liposomal doxorubicin is primarily used for the treatment of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36873
更新日期:2016-11-11 00:00:00
abstract::In this paper, we propose an angle- and polarization-insensitive metamaterial absorber. We design a metamaterial unit cell that is based on a split ring cross resonator (SRCR). We observe that the absorption frequency and absorption ratio are insensitive to incident angles when a via array surrounds the SRR. We demons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39686
更新日期:2016-12-21 00:00:00
abstract::Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demons...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45890-w
更新日期:2019-07-01 00:00:00
abstract::The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14640-1
更新日期:2017-10-27 00:00:00
abstract::Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67055-w
更新日期:2020-06-17 00:00:00
abstract::Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20589
更新日期:2016-02-05 00:00:00
abstract::Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79666-4
更新日期:2021-01-14 00:00:00
abstract::Humans are good at selectively listening to specific target conversations, even in the presence of multiple concurrent speakers. In our research, we study how auditory-visual cues modulate this selective listening. We do so by using immersive Virtual Reality technologies with spatialized audio. Exposing 32 participant...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-04201-x
更新日期:2017-06-19 00:00:00
abstract::Food webs in high-latitude oceans are dominated by relatively few species. Future ocean and sea-ice changes affecting the distribution of such species will impact the structure and functioning of whole ecosystems. Antarctic krill (Euphausia superba) is a key species in Southern Ocean food webs, but there is little und...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07205-9
更新日期:2017-07-31 00:00:00
abstract::Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63904-w
更新日期:2020-04-27 00:00:00
abstract::Polar bears are ice-associated marine mammals that are known to swim and dive, yet their aquatic behaviour is poorly documented. Reductions in Arctic sea ice are clearly a major threat to this species, but understanding polar bears' potential behavioural plasticity with respect to the ongoing changes requires knowledg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27947-4
更新日期:2018-06-26 00:00:00
abstract::In this work we have studied the effects of pharmacological concentrations of melatonin (1 µM-1 mM) on pancreatic stellate cells (PSC). Cell viability was analyzed by AlamarBlue test. Production of reactive oxygen species (ROS) was monitored following CM-H2DCFDA and MitoSOX Red-derived fluorescence. Total protein carb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63433-6
更新日期:2020-04-14 00:00:00
abstract::Jaw1/LRMP is a type II integral membrane protein that is localized at the endoplasmic reticulum (ER) and outer nuclear membrane. We previously reported that a function of Jaw1 is to maintain the nuclear shape as a KASH protein via its carboxyl terminal region, a component of linker of nucleoskeleton and cytoskeleton c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80258-5
更新日期:2021-01-12 00:00:00
abstract::Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03429-x
更新日期:2017-06-07 00:00:00
abstract::The ability to arrange cells and/or microparticles into the desired pattern is critical in biological, chemical, and metamaterial studies and other applications. Researchers have developed a variety of patterning techniques, which either have a limited capacity to simultaneously trap massive particles or lack the spat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14802-1
更新日期:2017-10-30 00:00:00
abstract::Accumulating evidence implies that both AKT1 and GABAA receptor (GABAAR) subunit genes are involved in schizophrenia pathogenesis. Activated Akt promotes GABAergic neuron differentiation and increases GABAAR expression on the plasma membrane. To elucidate the role of Akt1 in modulating GABAergic functions and schizoph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33095
更新日期:2016-09-12 00:00:00
abstract::BaTi1-xSnxO3 (BTSn, 0 ≤ x ≤ 0.30) ceramics were prepared by both the conventional sintering (CS) and sparking plasma sintering (SPS). Composition, temperature and grain size dependences of the nonlinear dielectric behaviors were systematically studied. BTSn was found to have especially large tunability (≥90%), which i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07192-x
更新日期:2017-07-27 00:00:00