Abstract:
OBJECTIVES:To investigate potential delays in endogenous melatonin in individuals with obsessive-compulsive disorder (OCD). METHODS:First, data are presented for 15 individuals with OCD and matched healthy controls. Next, nine additional participants with OCD who did not have matched controls were added, resulting in a sample of 24 individuals with OCD. All participants were assessed for sleep and circadian rhythm disturbance. Dim light melatonin onset (DLMO) was derived from salivary melatonin and was used in conjunction with sleep diaries, interview measures, and questionnaires. A subset of the OCD group (n = 16) also used actigraphy. RESULTS:In sum, 42% percent (10/24) of the patients with OCD met the criteria for delayed sleep-wake phase disorder (DSWPD) in comparison to 0% in the control sample. DLMO was significantly later in individuals with OCD compared to controls. DLMO and bedtime were not significantly associated with the severity of obsessive-compulsive symptoms or negative affect. CONCLUSIONS:Replication of the findings presented herein, particularly the DLMO results, is warranted. Further, there are now three studies showing that nearly ½ of individuals with OCD meet criteria for a DSWPD. Future studies can explore the mechanisms underlying these connections and the implications of this comorbidity. These findings may increase our understanding of OCD and inform future interventions.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Coles ME,Schubert J,Stewart E,Sharkey KM,Deak Mdoi
10.1016/j.sleep.2020.03.021subject
Has Abstractpub_date
2020-08-01 00:00:00pages
111-117eissn
1389-9457issn
1878-5506pii
S1389-9457(20)30140-4journal_volume
72pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract:OBJECTIVE:We aim to investigate if anatomical and functional properties of the upper airway using computerized 3D models derived from computed tomography (CT) scans better predict obstructive sleep apnea (OSA) severity than standard clinical markers. METHODS:Consecutive children with suspected OSA underwent polysomnog...
journal_title:Sleep medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.sleep.2012.12.005
更新日期:2013-05-01 00:00:00
abstract::We describe a polysomnographic observation of the acute phase of the alcohol withdrawal syndrome, characterized by an alteration of the sleep-wake cycle and by the absence of non-rapid eye movement sleep. An atypical transitional state between rapid eye movement sleep and wake with hallucinations and enacting-dream be...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00014-x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers. METHODS:With informed conse...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2008.12.017
更新日期:2010-01-01 00:00:00
abstract::A 63-year-old right-handed woman developed an alien hand syndrome (AHS) after an acute infarction in the territory of the left anterior cerebral artery. The uncontrolled hand movements were present during the daytime and eventually disturbed sleep. Polysomnography revealed that these motor actions only appeared when t...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00236-8
更新日期:2003-05-01 00:00:00
abstract:STUDY OBJECTIVES:Few commercially available brands of actigraphs (ACT) have been subjected to rigorous validation with infant participants. The purpose of this study was to examine the agreement between concurrent polysomnography (PSG) and one brand of ACT (AW-64, Mitter Co. Inc.) using appropriate statistical techniqu...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2009.08.010
更新日期:2010-02-01 00:00:00
abstract::A multiple sleep latency test (MSLT) with occurrence of sleep onset REM periods (SOREMP) is considered one of the central diagnostic criteria for narcolepsy according to the International Classification of Sleep Disorders, but its sensitivity and specificity have been questioned. This study aims to describe MSLT and p...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.12.037
更新日期:2021-01-02 00:00:00
abstract::Sleep is a fairly diverse and complex construct to operationalize in a scientific and naturalistic context. We report a systematic review and meta-analysis of reviews published in the last 5 years on poor sleep and developmental outcomes. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses...
journal_title:Sleep medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.sleep.2018.11.021
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:There is a dearth of data on the longitudinal course and outcome of non-restorative sleep (NRS). METHODS:A total of 2291 middle-aged adults (mean [SD]=46.3 [5.1] years old, 50.0% males at follow-up) were recruited into a 5-year follow-up study. NRS was defined as morning unfreshness after getting up ≥ 3 tim...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2011.12.012
更新日期:2012-06-01 00:00:00
abstract::In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2006.11.008
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Extensive empirical evidence indicates that sleep plays an active role in memory consolidation. Moreover, sleep has been found to preferentially enhance emotional memories and may modulate affective reactions to previously encountered stimuli. Notably, recent findings suggest that disruptions of sleep-relate...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.10.030
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Sleep-disordered breathing (SDB) is often co-morbid with conductive hearing loss in early childhood due to a shared aetiology of adenotonsillar hypertrophy. Hearing loss is independently associated with impairment of executive function and behavioural difficulties. We hypothesised that these impairments in c...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.02.008
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Very few prospective studies examine the relationship between childhood sleep problems and subsequent substance use. In this study, we examined how sleep problems at ages 3-8 predicted onset of alcohol, cigarette, and marijuana use in adolescence. We also investigated the relationships between childhood slee...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2008.06.015
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associat...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.02.007
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Arousal dysregulation has been speculated to be involved in the pathological mechanism of attention deficit/hyperactivity disorder (ADHD). However, there has been no epidemiological study assessing the real condition of excessive daytime sleepiness (EDS) in adults with ADHD. This study investigated the preva...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.04.008
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Ramelteon, an MT(1)/MT(2) melatonin receptor agonist, was evaluated for its ability to reduce sleep-onset difficulties associated with eastward jet travel. METHODS:Healthy adults (n=110) with a history of jet lag sleep disturbances were flown eastward across five time zones from Hawaii to the east coast of t...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2010.03.010
更新日期:2010-06-01 00:00:00
abstract::Sleep-related eating disorder (SRED) is characterized by nocturnal partial arousals associated with compulsive consumption of food and altered levels of consciousness. Reports of an increased incidence of SRED in relatives of affected individuals suggest a genetic predisposition. We report a woman with SRED whose frat...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00137-5
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Observational evidence suggests that atypical antipsychotics such as quetiapine are increasingly being used to manage insomnia. This is concerning given the uncertain efficacy and potential adverse effects associated with these medications. OBJECTIVES:The objectives of this study are to evaluate the benefit...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2016.04.003
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS:42 DSWPD (22 female, mean age 34.5 y) and 26 (±4 years) age-and-sex-matched controls (12 female...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.09.009
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Although there is a growing interest in the independent effect of snoring on carotid atherosclerosis, few studies have observed the relationship between snoring and change in carotid atherosclerosis prospectively. Therefore, the present study aimed to prospectively examine the association of snoring with subc...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2014.03.009
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Later school start times for adolescents have been implemented in the US and associated benefits found, although no randomised controlled trials (RCT) have been undertaken. The objective of this study was to evaluate the impact of two school interventions in the UK, a delayed start time and a sleep education ...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2018.10.021
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The present study aimed to clarify the prevalence and risk factors of insomnia among public school teachers in Japan by examining the relationships between working hours, commuting time, and insomnia. Time spent on work activities among teachers with insomnia was also investigated. METHODS:This study was a ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.09.017
更新日期:2020-11-01 00:00:00
abstract::Pregnant women have at least two or three times higher risk of experiencing restless legs syndrome (RLS) than the general population. These data come from few epidemiological studies finding an 11-27% prevalence of RLS during pregnancy. Women affected by pre-existing RLS often complain of worsening symptoms during pre...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2004.01.013
更新日期:2004-05-01 00:00:00
abstract::This chapter addresses the use of long-term non-invasive positive pressure ventilation (NIPPV) (to the exclusion of continuous positive airway pressure) in the different clinical settings in which it is currently proposed: principally in diseases responsible for hypoventilation characterized by elevated PaCO(2). Nasal...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2007.03.009
更新日期:2007-06-01 00:00:00
abstract::Angelman syndrome is a neurogenetic condition characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioral phenotype that includes sleep problems. It is caused by lack of expression of the UBE3A gene on the maternal chromosome 15q11-q13. Although part of the diagnostic ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2007.07.001
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Cerebral small vessel disease (CSVD) is a well-known cause of vascular dementia, a leading medical morbidity in the aging population. Obstructive sleep apnea (OSA) has been validated as a cardiovascular risk factor. However, the relationship between these two clinical syndromes is not well established. We ai...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.11.1262
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Augmentation can occur frequently in restless legs syndrome (RLS) patients treated with dopaminergic agents. Video-polysomnographic (PSG) data from augmented RLS patients are scant. The aim of this study was to evaluate PSG findings in augmented RLS patients and compare them with those of non-...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.04.010
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Insomnia represents a significant public health burden worldwide. Antidepressants have often been the insomnia treatment of choice in recent decades. Some tricyclic antidepressants (TCAs) have been shown to improve sleep efficiency. OBJECTIVE:Assess the efficacy and safety of TCAs for the treatment of insom...
journal_title:Sleep medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.sleep.2017.03.007
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) and asthma are common and share similar nocturnal symptoms. We hypothesized that the prevalence of OSA symptoms would be greater in asthmatics compared to a general internal medicine population. METHODS:Patients in the Asthma Clinics (n=177) and Internal Medicine Clinics (n=328...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2007.06.010
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Insomnia marked by sleep maintenance difficulty is extremely prevalent. Yet, problems staying asleep have been relatively neglected as a research focus compared to problems falling asleep. Insomnia treatment studies typically have not required participants to have a problem specifically with sleep maintenanc...
journal_title:Sleep medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.sleep.2012.01.010
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study was conducted to demonstrate the long-term efficacy of sodium oxybate for the long-term treatment of cataplexy in patients with narcolepsy. PATIENTS AND METHODS:Fifty-five (55) narcoleptic patients with cataplexy who had received continuous treatment with sodium oxybate for 7-44 month...
journal_title:Sleep medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.sleep.2003.11.002
更新日期:2004-03-01 00:00:00