In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells.

abstract：:The fates of genetic polymorphisms maintained by balancing selection depend on evolutionary dynamics at linked sites. While coevolution across linked, epigenetically-interacting loci has been extensively explored, such supergenes may be relatively rare. However, genes harboring adaptive variation can occur in close ph...

journal_title：PeerJ

authors： Tennessen JA

更新日期：2018-06-28 00:00:00

abstract：BACKGROUND:Habitat selection and its adaptive outcomes are crucial features for animal life-history strategies. Nevertheless, congruence between habitat preferences and breeding success has been rarely demonstrated, which may result from the single-scale evaluation of animal choices. As habitat selection is a complex m...

journal_title：PeerJ

authors： Jedlikowski J,Brambilla M

更新日期：2017-03-28 00:00:00

abstract：:The common bottlenose dolphin, Tursiops truncatus, is widely distributed along the western coast of South America. In Ecuador, a resident population of bottlenose dolphins inhabits the inner estuarine area of the Gulf of Guayaquil located in the southwestern part of the country and is under threat from different human...

journal_title：PeerJ

authors： Bayas-Rea RLÁ,Félix F,Montufar R

更新日期：2018-04-09 00:00:00

abstract：:Human hands, when compared to that of apes, have a series of adaptations to facilitate manipulation. Numerous studies have shown that Australopithecus afarensis and Au. africanus display some of these adaptations, such as a longer thumb relative to the other fingers, asymmetric heads on the second and fifth metacarpal...

journal_title：PeerJ

authors： Drapeau MS

更新日期：2015-10-06 00:00:00

abstract：:In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determin...

journal_title：PeerJ

authors： Romo-Quiñonez CR,Álvarez-Sánchez AR,Álvarez-Ruiz P,Chávez-Sánchez MC,Bogdanchikova N,Pestryakov A,Mejia-Ruiz CH

更新日期：2020-02-27 00:00:00

abstract：:Genome sequencing is rapidly being adopted in reference labs and hospitals for bacterial outbreak investigation and diagnostics where time is critical. Seven gene multi-locus sequence typing is a standard tool for broadly classifying samples into sequence types (STs), allowing, in many cases, to rule a sample out of a...

journal_title：PeerJ

authors： Page AJ,Keane JA

更新日期：2018-07-31 00:00:00

abstract：:Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort of chronic dialysis patients was assembled. The pres...

journal_title：PeerJ

authors： Chao CT,Huang JW,COGENT (COhort of GEriatric Nephrology in NTUH) study group.

更新日期：2016-06-14 00:00:00

abstract：:Defensive traits exhibited by plants vary widely across populations. Heritable phenotypic differentiation is likely to be produced by genetic drift and spatially restricted gene flow between populations. However, spatially variable selection exerted by herbivores may also give rise to differences among populations. To...

journal_title：PeerJ

authors： Castillo G,Valverde PL,Cruz LL,Hernández-Cumplido J,Andraca-Gómez G,Fornoni J,Sandoval-Castellanos E,Olmedo-Vicente E,Flores-Ortiz CM,Núñez-Farfán J

更新日期：2015-11-26 00:00:00

abstract：:Background. Eucryptodiran turtles from the Late Jurassic (mainly Kimmeridgian) deposits of the Jura Mountains (Switzerland and France) are among the earliest named species traditionally referred to the Plesiochelyidae, Thalassemydidae, and Eurysternidae. As such, they are a reference for the study of Late Jurassic euc...

journal_title：PeerJ

authors： Anquetin J,Püntener C,Billon-Bruyat JP

更新日期：2014-05-13 00:00:00

abstract：:The active place avoidance task is a dry-arena task used to assess spatial navigation and memory in rodents. In this task, a subject is put on a rotating circular arena and avoids an invisible sector that is stable in relation to the room. Rotation of the arena means that the subject's avoidance must be active, otherw...

journal_title：PeerJ

authors： Bahník Š,Stuchlík A

更新日期：2015-09-22 00:00:00

abstract：:Banana streak virus (BSV) belongs to the members of the genus Badnavirus, family Caulimoviridae. At present, BSV contains nine species in the International Committee on Taxonomy of Viruses (ICTV) classification report (2018b release). Previous study indicated that the viral particles of Banana streak virus Acuminata Y...

journal_title：PeerJ

authors： Li WL,Yu NT,Wang JH,Li JC,Liu ZX

更新日期：2020-01-27 00:00:00

abstract：:Cordycepin is a component of the extract obtained from Cordyceps militaris and has many biological activities, including anti-cancer, anti-metastatic and anti-inflammatory effects. Intervertebral disc degeneration (IDD) is a degenerative disease that is closely related to the inflammation of nucleus pulposus (NP) cell...

journal_title：PeerJ

authors： Li Y,Li K,Mao L,Han X,Zhang K,Zhao C,Zhao J

更新日期：2016-05-10 00:00:00

abstract：:Although anthophilous Coleoptera are regarded to be unspecialised flower-visiting insects, monkey beetles (Scarabaeidae: Hopliini) represent one of the most important groups of pollinating insects in South Africa's floristic hotspot of the Greater Cape Region. South African monkey beetles are known to feed on floral t...

journal_title：PeerJ

authors： Karolyi F,Hansal T,Krenn HW,Colville JF

更新日期：2016-01-21 00:00:00

abstract：Background:Methylenetetrahydrofolate reductase (MTHFR) is indispensable for the conversion of homocysteine (Hcy) to methionine. The single nucleotide polymorphism (SNP) of MTHFR gene (rs1801133, C667T) is correlated with decreased enzyme activity that eventually results in elevated plasma Hcy levels. Hyperhomocysteinem...

journal_title：PeerJ

authors： Yuan H,Fu M,Yang X,Huang K,Ren X

更新日期：2020-02-20 00:00:00

abstract：:Background. Genome-wide association studies have succeeded in detecting novel common variants which associate with complex diseases. As a result of the fast changes in next generation sequencing technology, a large number of sequencing data are generated, which offers great opportunities to identify rare variants that...

journal_title：PeerJ

authors： Sun L,Wang C,Hu YQ

更新日期：2016-06-16 00:00:00

abstract：Background:In arid environments, plant primary productivity is generally low and highly variable both spatially and temporally. Resources are not evenly distributed in space and time (e.g., soil nutrients, water), and depend on global (El Niño/ Southern Oscillation) and local climate parameters. The launch of the Senti...

journal_title：PeerJ

authors： Funghi C,Heim RHJ,Schuett W,Griffith SC,Oldeland J

更新日期：2020-05-26 00:00:00

abstract：:Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam. A torque meter measures the turning attempts of the tethered fly around its vertical body axis. By punishing, say, left turning attempts (in a homogeneous env...

journal_title：PeerJ

authors： Colomb J,Brembs B

更新日期：2016-04-25 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. METHODS:Cancer survivors within 24 months post-diagnosis were r...

journal_title：PeerJ

authors： Toohey K,Pumpa KL,Arnolda L,Cooke J,Yip D,Craft PS,Semple S

更新日期：2016-10-20 00:00:00

abstract：:Vitiligo is a chronic asymptomatic disorder affecting melanocytes from the basal layer of the epidermis which leads to a patchy loss of skin color. Even though it is one of the neglected disease conditions, people suffering from vitiligo are more prone to psychological disorders. As of now, various studies have been d...

journal_title：PeerJ

authors： Srivastava P,Choudhury A,Talwar M,Mohanty S,Narad P,Sengupta A

更新日期：2020-05-21 00:00:00

abstract：:Background. Climate change concurrent with anthropogenic disturbances can initiate serial changes that reverberate up the food chain with repercussions for fisheries. To date, there is no information available concerning the combined effects of global warming and human impacts on tropical marine food webs. While tempe...

journal_title：PeerJ

authors： Chew LL,Chong VC

更新日期：2016-05-24 00:00:00

abstract：:Climate change will significantly affect plant distribution as well as the quality of medicinal plants. Although numerous studies have analyzed the effect of climate change on future habitats of plants through species distribution models (SDMs), few of them have incorporated the change of effective content of medicina...

journal_title：PeerJ

authors： Guo Y,Wei H,Lu C,Gao B,Gu W

更新日期：2016-10-20 00:00:00

abstract：:Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges were assessed via hydrolysis and enzymolysis. To stu...

journal_title：PeerJ

authors： Long H,Ma K,Xiao Z,Ren X,Yang G

更新日期：2017-08-09 00:00:00

abstract：:[This corrects the article DOI: 10.7717/peerj.2869.]. ...

journal_title：PeerJ

authors： Qiu S,Sun H,Liu Y,Kanu JS,Li R,Yu Y,Huang X,Li B,Zhang X

更新日期：2017-12-07 00:00:00

abstract：:Female adders (Vipera berus) are "capital breeders" that exhibit delayed maturity and intermittent reproductive frequency. We studied the attainment of sexual maturity, the initiation of annual breeding in mature females, the energy and mortality costs associated with breeding, the length of the reproductive cycle and...

journal_title：PeerJ

authors： Bauwens D,Claus K

更新日期：2019-05-09 00:00:00

abstract：:We often expect that investigations of the patterns, causes, and consequences of among-individual variation in a trait of interest will reveal how selective pressures or ecological conditions influence that trait. However, many endocrine traits, such as concentrations of glucocorticoid (GC) hormones, exhibit adaptive ...

journal_title：PeerJ

authors： Schoenemann KL,Bonier F

更新日期：2018-02-21 00:00:00

abstract：:Species interactions are a key component of ecosystems but we generally have an incomplete picture of who-eats-who in a given community. Different techniques have been devised to predict species interactions using theoretical models or abundances. Here, we explore the K nearest neighbour approach, with a special empha...

journal_title：PeerJ

authors： Desjardins-Proulx P,Laigle I,Poisot T,Gravel D

更新日期：2017-08-10 00:00:00

abstract：Background:Lysyl oxidases (LOX) have been extensively studied in mammals, whereas properties and functions of recently found homologues in prokaryotic genomes remain enigmatic. Methods:LOX open reading frame was cloned from Haloterrigena turkmenica in an E. coli expression vector. Recombinant Haloterrigena turkmenica ...

journal_title：PeerJ

authors： Pestov NB,Kalinovsky DV,Larionova TD,Zakirova AZ,Modyanov NN,Okkelman IA,Korneenko TV

更新日期：2019-04-05 00:00:00

abstract：:While there have been increasing numbers of reports of human-wolf conflict in China during recent years, little is known about the nature of this conflict. In this study, we used questionnaires and semi-structured interviews to investigate local villagers' perceptions of wolves in Jiuzhaigou County, western China. We ...

journal_title：PeerJ

authors： Xu Y,Yang B,Dou L

更新日期：2015-06-09 00:00:00

abstract：:Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive ...

journal_title：PeerJ

authors： Dakic V,Maciel RM,Drummond H,Nascimento JM,Trindade P,Rehen SK

更新日期：2016-12-06 00:00:00

abstract：:In contrast to dominant mode of ecological transition in the evolution of marine mammals, different lineages of toothed whales (Odontoceti) have repeatedly invaded freshwater ecosystems during the Cenozoic era. The so-called 'river dolphins' are now recognized as independent lineages that converged on similar morpholo...

journal_title：PeerJ

authors： Pyenson ND,Vélez-Juarbe J,Gutstein CS,Little H,Vigil D,O'Dea A

更新日期：2015-09-01 00:00:00