Abstract：
:Chronic stress is regarded as a significant factor in the etiology of the many diseases. Numerous methods have been developed through which the effect of chronic stress is examined. The aim of this study is to demonstrate the new experimental model for analysis of immuno-suppression induced by chronic restraint stress, through challenge with conditionally tumorigenic cell line BHK-21/C13. 20 male NMRI mice were randomly divided into 2 groups-control and experimental. Each mouse was subcutaneously inoculated with BHK-21/C13 cells. Stress in the experimental group was induced for 20 days. After the experiment, tumor masses were removed, and analyzed using histology and immunohistochemistry techniques. We found a statistically significant difference (p = 0.034) in tumor expression and tumor volumes (p = 0.0061) between groups, as well as in immunopositivity on Ki67, cytochrome C and matrix metalloproteinase 9. Absence of immune infiltrate was noticed in experimental, and the presence of inflammatory infiltrate at tumor invasion front in control group.
journal_name
J Mol Histoljournal_title
Journal of molecular histologyauthors
Smieško G,Banović P,Gusman V,Simin V,Cimpean AM,Lalošević Ddoi
10.1007/s10735-020-09886-5subject
Has Abstractpub_date
2020-08-01 00:00:00pages
367-374issue
4eissn
1567-2379issn
1567-2387pii
10.1007/s10735-020-09886-5journal_volume
51pub_type
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journal_title：Journal of molecular histology
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journal_title：Journal of molecular histology
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