Abstract:
:Tsetse flies are responsible for the transmission of Trypanossoma sp. to vertebrate animals in Africa causing huge health issues and economic loss. The availability of the genome sequence of Glossina morsitans enabled the discovery of several genes related to medically important phenotypes and novel physiological features. However, a genome-wide scan for coding regions that underwent positive selection is still missing, which is surprising given the evolution of traits associated with the hematophagy in this lineage. In this study, we employed an experimental design that controlled for the rate of false positives and we performed a scan of 3,318 G. morsitans genes. We found 145 genes with significant historical signal of positive selection. These genes were categorized into 18 functional classes after careful manual annotation. Based on their attributed functions, we identified candidate genes related with feeding habits and embryonic development. When our results were contrasted with gene expression data, we confirmed that most genes that underwent adaptive molecular evolution were frequently expressed in organs associated with key physiological evolutionary innovations in the G. morsitans lineage, namely, the salivary gland, the midgut, fat body tissue, and in the spermatophore.
journal_name
Genet Mol Bioljournal_title
Genetics and molecular biologyauthors
Freitas L,Mesquita RD,Schrago CGdoi
10.1590/1678-4685-GMB-2018-0311subject
Has Abstractpub_date
2020-06-10 00:00:00pages
e20180311issue
2eissn
1415-4757issn
1678-4685pii
S1415-47572020000400608journal_volume
43pub_type
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