Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm.

Abstract:

:Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms triggering IA formation remain to be elucidated. To clarify them, computational fluid dynamics (CFD) and histopathological analyses in the early phase of IA development using an experimentally induced IA model in rats were conducted. Histological changes in the early phase of IA development were observed under a scanning electron microscope (SEM) and a transmission electron microscope (TEM). Using data from 7-T magnetic resonance angiography (7T-MRA), CFD analyses were performed to determine wall shear stress (WSS) and wall pressure (WP) at the prospective site of IA. A bump-like protrusion named an "intimal pad" was located in the anterior cerebral artery (ACA) immediately distal to the apex of the bifurcation. TEM showed the degeneration of the internal elastic lamina (IEL) and longitudinally elongated smooth muscle cells (SMCs) that switched from the contractile to the proliferative phenotype and penetrated between two divided layers of the degenerated IEL in the prospective site of the IA. However, no inflammatory cells were observed. CFD analyses showed no particular pattern of WSS and WP at the prospective IA site. IEL degeneration and the phenotypic change and longitudinal elongation of SMCs were identified as the early events in IA development. CFD analyses and TEM data suggest that these biological events may be derived from increased circumferential wall stress due to increased blood pressure and increased longitudinal wall strain due to the existence of the intimal pad.

authors

Kataoka H,Yagi T,Ikedo T,Imai H,Kawamura K,Yoshida K,Nakamura M,Aoki T,Miyamoto S

doi

10.2176/nmc.st.2020-0072

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

319-328

issue

7

eissn

0470-8105

issn

1349-8029

journal_volume

60

pub_type

杂志文章
  • Neuroimaging of a wooden foreign body retained for 5 months in the temporalis muscle following penetrating trauma with a chopstick--case report.

    abstract::A 48-year-old female was stabbed by her husband with a chopstick made of wood in the left temporal region during a quarrel. She suffered laceration of the left temporal scalp. At initial examination, she concealed the assault with a chopstick. Radiography showed no abnormality, so the wound was sutured. One month afte...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.39.744

    authors: Ochiai H,Yamakawa Y,Fukushima T,Yamada H

    更新日期:1999-10-01 00:00:00

  • Ruptured fusiform aneurysm of the proximal anterior cerebral artery (A1 segment).

    abstract::A 42-year-old man presented with a ruptured fusiform aneurysm of the proximal anterior cerebral artery (A(1) segment) manifesting as sudden onset of severe headache. Brain computed tomography revealed subarachnoid hemorrhage in the basal cisterns, and left carotid angiography demonstrated a fusiform aneurysm of the le...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.47.351

    authors: Aoki Y,Nemoto M,Yokota K,Kano T,Goto S,Sugo N

    更新日期:2007-08-01 00:00:00

  • Working Conditions and Lifestyle of Female Surgeons Affiliated to the Japan Neurosurgical Society: Findings of Individual and Institutional Surveys.

    abstract::To investigate the working conditions of female neurosurgeons in Japan, two surveys were conducted by The Japan Neurosurgical Society: one involving female neurosurgeons themselves and the other involving the chiefs of neurosurgical departments. The responses were received from 224 (43.8%) female neurosurgeons and 496...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2016-0119

    authors: Fujimaki T,Shibui S,Kato Y,Matsumura A,Yamasaki M,Date I,Hongo K,Kuroda S,Matsumae M,Nakao N,Sakurada K,Shimokawa S,Kayama T,Gender Equality Committee of the Japan Neurosurgical Society.

    更新日期:2016-11-15 00:00:00

  • Myelodysplastic syndrome following therapy for brain tumor--two case reports.

    abstract::A 3-month-old boy and a 29-year-old woman presented with myelodysplastic syndrome (MDS) following therapy for primary malignant brain tumor. Both received intensive alkylating agent doses for induction and maintenance chemotherapy combined with craniospinal or cranial radiation for medulloblastoma and anaplastic astro...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.42.170

    authors: Sugiyama K,Kurisu K,Arita K,Taniguchi E,Okamura T,Itoh Y,Yamasaki F,Kajiwara Y,Ueda H,Sakai A

    更新日期:2002-04-01 00:00:00

  • Surgical treatment of lumbar canal stenosis in the elderly.

    abstract::The effectiveness of spinal surgery for lumbar canal stenosis was investigated in the elderly. 164 patients with lumbar canal stenosis were surgically treated over 8 years. 125 patients were followed up by letter questionnaire. The outcome and patient satisfaction with the surgical procedures were compared between the...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.39.519

    authors: Hanakita J,Suwa H,Mizuno M

    更新日期:1999-07-01 00:00:00

  • Cine-magnetic resonance imaging evaluation of communication between middle cranial fossa arachnoid cysts and cisterns.

    abstract::Cine-magnetic resonance (MR) imaging examinations were performed in 10 patients with middle cranial fossa arachnoid cysts to evaluate communication between the cysts and the normal cerebrospinal fluid (CSF) space. Eight of 10 patients were evaluated by time of flight cine-MR imaging, and two by phase contrast cine-MR ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.353

    authors: Eguchi T,Taoka T,Nikaido Y,Shiomi K,Fujimoto T,Otsuka H,Takeuchi H

    更新日期:1996-06-01 00:00:00

  • Ruptured extracranial vertebral artery aneurysm associated with neurofibromatosis type 1. Case report.

    abstract::A 31-year-old man presented with a ruptured right extracranial vertebral artery aneurysm associated with neurofibromatosis type 1, manifesting as acute onset of right neck and shoulder pain, and right supraclavicular mass. Three-dimensional computed tomography angiography showed a large aneurysm involving the right ex...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.52.446

    authors: Hiramatsu H,Matsui S,Yamashita S,Kamiya M,Yamashita T,Akai K,Watanabe K,Namba H

    更新日期:2012-01-01 00:00:00

  • Spontaneous vertebral arteriovenous fistula--case report.

    abstract::A 57-year-old male presented with a rare case of spontaneous vertebral arteriovenous fistula manifesting as radiculopathy of the right arm, subsequently associated with pulsating tinnitus and vascular bruit in the nape. He had a past history of chiropractic-induced vertebrobasilar infarction. Angiography showed a simp...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.40.211

    authors: Yoshida S,Nakazawa K,Oda Y

    更新日期:2000-04-01 00:00:00

  • Subependymoma in the lateral ventricle manifesting as intraventricular hemorrhage.

    abstract::A 32-year-old man presented with subependymoma in the lateral ventricle causing intraventricular hemorrhage and manifesting as severe headache and disturbance of consciousness. Computed tomography on admission showed a massive intraventricular hemorrhage and acute obstructive hydrocephalus. Cerebral angiography reveal...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.50.1020

    authors: Akamatsu Y,Utsunomiya A,Suzuki S,Endo T,Suzuki I,Nishimura S,Ezura M,Suzuki H,Uenohara H,Tominaga T

    更新日期:2010-01-01 00:00:00

  • Microcystic meningioma without enhancement on neuroimaging--case report.

    abstract::A 63-year-old female presented with an unusual case of microcystic meningioma manifesting as a 4-year history of unsteady gait, dysarthria, and hearing loss. Computed tomography disclosed a large hypodense mass in the right cerebellopontine angle, clivus, and middle fossa, with slight contrast enhancement. T1-weighted...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.37.407

    authors: Kubota Y,Ueda T,Kagawa Y,Sakai N,Hara A

    更新日期:1997-05-01 00:00:00

  • Progression of intracranial meningioma during luteinizing hormone-releasing hormone agonist treatment for prostate cancer: case report.

    abstract::The authors describe a male patient who developed a large intracranial meningioma during the hormone therapy for pre-existing prostate cancer. A 70-year-old man received a brain check-up, and no intracranial abnormality was detected. Five months later, prostate cancer was diagnosed, and he underwent prostatectomy. Leu...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.cr2012-0417

    authors: Anda T,Honda M,Ishihara T,Kamei T

    更新日期:2014-01-01 00:00:00

  • Risk Factor for Additional Intravenous Medication during Transforaminal Full-endoscopic Lumbar Discectomy under Local Anesthesia.

    abstract::Transforaminal full-endoscopic lumbar discectomy (TELD) can be performed under local anesthesia. However, there have been no reports on risk factors for a change in vital signs or the need for additional medications to maintain adequate analgesia during this procedure. The purpose of this study was to identify risk fa...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2020-0275

    authors: Yamaya S,Tezuka F,Sugiura K,Takeuchi M,Manabe H,Morimoto M,Yamashita K,Takata Y,Sakai T,Maeda T,Sairyo K

    更新日期:2021-01-28 00:00:00

  • [Brain metastasis from primary pericardial mesothelioma. Case report].

    abstract::A 50-year-old female was admitted because of nausea, vomiting, and cerebellar ataxia. Computed tomography scan revealed an enhanced mass accompanied with a cyst in the right cerebellar hemisphere. The mass situated in the subcortical region was removed. Histologically, highly vascular tumor cells lined the cavities. P...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.30.884

    authors: Asoh Y,Nakamura M,Maeda T,Shiogai T,Ogashiwa M,Takeuchi K,Watanabe K,Tanaka U,Matsuo E

    更新日期:1990-01-01 00:00:00

  • Spinal subdural hematoma following intracranial aneurysm surgery: four case reports.

    abstract::Four patients presented with rare spinal subdural hematoma (SDH) occurring after intracranial aneurysm surgery and manifesting as postoperative back pain. Magnetic resonance imaging performed from 4 to 11 days after the operation showed acute or subacute thoracolumbar SDH. No patient had risk factors for bleeding at t...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.47.22

    authors: Kim MS,Lee CH,Lee SJ,Rhee JJ

    更新日期:2007-01-01 00:00:00

  • Aspergillus mycotic aneurysm--case report.

    abstract::A 61-year-old female developed subarachnoid hemorrhage after trans-sphenoidal surgery for Rathke's cleft cyst. Neuroradiological examination revealed a large aneurysm at the C1 portion of the right internal carotid artery. Autopsy revealed marked proliferation of aspergillus hyphae in the wall of the aneurysm. A revie...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.31.346

    authors: Komatsu Y,Narushima K,Kobayashi E,Tomono Y,Nose T

    更新日期:1991-06-01 00:00:00

  • Meningeal hemangiopericytoma manifesting as massive intracranial hemorrhage--two case reports.

    abstract::Meningeal hemangiopericytoma is rare, and only seven cases have manifested as intracranial hemorrhage. We treated two patients with meningeal hemangiopericytoma manifesting as life-threatening massive intracerebral hemorrhage. Case 1: A 66-year-old woman presented with consciousness disturbance and left hemiparesis. C...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.46.92

    authors: Maruya J,Seki Y,Morita K,Nishimaki K,Minakawa T

    更新日期:2006-02-01 00:00:00

  • Dolichoectatic basilar artery treated by reducing hemodynamic stress--report of two cases.

    abstract::Two cases of dolichoectatic basilar artery with a mass effect to the brainstem structure were treated by reducing hemodynamic stress. In one case, angiograms showed the dolichoectatic basilar artery creating a turbulent flow in the vertebrobasilar junction, and unilateral vertebral artery clipping in addition to poste...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.30.691

    authors: Matsumoto K,Yamada K,Hayakawa T,Kataoka K,Yamamoto K,Onishi T,Ito M,Mogami H

    更新日期:1990-09-01 00:00:00

  • Treatment selection for ruptured aneurysm and outcomes: clipping or coil embolization.

    abstract::The International Subarachnoid Aneurysm Trial has shown that coil embolization achieves a better outcome for aneurysms treatable by either clipping or coil embolization. However, many ruptured aneurysms are hardly treatable by either clipping or coil embolization. Selection of either clipping or coil embolization will...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.23

    authors: Tenjin H,Takadou M,Ogawa T,Mandai A,Umebayashi D,Osaka Y,Nakahara Y,Kubo S

    更新日期:2011-01-01 00:00:00

  • Spontaneous slow drainage of epidural hematoma into the subgaleal space through a skull fracture in an infant--case report.

    abstract::A 4-month-old girl fell off a table onto the floor. Computed tomography performed 4 hours after the trauma showed a left parietal epidural hematoma (EDH) with an omega-shaped fracture line in the left parietal region. The EDH was enlarged after another 4 hours. However, the EDH showed drainage into the subgaleal space...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.51.854

    authors: Chida K,Yukawa H,Mase T,Endo H,Ogasawara K

    更新日期:2011-01-01 00:00:00

  • Intracranial cavernous angioma manifesting as subarachnoid hemorrhage--case report.

    abstract::A 56-year-old male presented with a posterior fossa cavernous angioma manifesting as persistent headache with mild neck stiffness. Lumbar puncture revealed subarachnoid hemorrhage (SAH). Repeated four-vessel angiography failed to identify the source of the SAH. Magnetic resonance (MR) imaging demonstrated multiple sma...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.33.706

    authors: Yamamoto M,Fukushima T,Ikeda K,Nagasaka S,Sakamoto S,Oka K,Tomonaga M,Maehara F

    更新日期:1993-10-01 00:00:00

  • Cerebral sinus thrombosis in patient with ulcerative colitis--case report.

    abstract::Left transverse sinus thrombosis developed in a 27-year-old male with ulcerative colitis. The diagnosis was based on cerebral angiography and magnetic resonance (MR) imaging, the latter of which clearly delineated the intraluminal thrombus. Serial MR images demonstrated thrombus organization. The use of this method in...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.32.232

    authors: Moriyama E,Shinohara C,Tokunaga K,Kamitani M,Norikane H,Matsumoto Y,Motoki M

    更新日期:1992-04-01 00:00:00

  • Recurrent brain abscess associated with hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease)--case report.

    abstract::A 53-year-old mentally handicapped female with hereditary hemorrhagic telangiectasia complicated by pulmonary arteriovenous fistula developed a recurrent brain abscess in the left frontal region. She responded well to surgical drainage and antibiotic therapy. Previously, she had two brain abscesses of the left parieto...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.32.891

    authors: Kikuchi K,Kowada M,Shioya H,Shioya T

    更新日期:1992-11-01 00:00:00

  • Multifocal primary intracerebral malignant fibrous histiocytoma--case report.

    abstract::A 58-year-old female presented with a unique case of multifocal primary intracerebral malignant fibrous histiocytoma (MFH) manifesting as partial seizure. Neuroimaging showed a mass lesion in the right frontal lobe, which was totally removed. The histological diagnosis was MFH. Follow-up neuroimaging one month after s...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章,评审

    doi:10.2176/nmc.44.249

    authors: Mitsuhashi T,Watanabe M,Ohara Y,Hatashita S,Ueno H

    更新日期:2004-05-01 00:00:00

  • Histopathological Features of Brain Arteriovenous Malformations in Japanese Patients.

    abstract::Clinical features of high risk brain arteriovenous malformations (BAVMs) are well characterized. However, pathological evidences about the differences that are possessed by high risk patients are still lacking. We reviewed archived routine hematoxylin-eosin specimens from a total of 54 surgical treated BAVMs. The hist...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2016-0032

    authors: Hermanto Y,Takagi Y,Yoshida K,Ishii A,Kikuchi T,Funaki T,Mineharu Y,Miyamoto S

    更新日期:2016-06-15 00:00:00

  • Immunohistochemical study of medulloblastoma with a monoclonal antibody against human copper and zinc-superoxide dismutase.

    abstract::Superoxide dismutase (SOD) expression in tumor tissues was investigated in 10 cases of medulloblastoma by immunohistochemistry, using a monoclonal antibody against human copper and zinc-superoxide dismutase. Abundant SOD was expressed in tumors from patients with poor outcomes and little SOD in patients with good outc...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.36.220

    authors: Kurisaka M,Mori K

    更新日期:1996-04-01 00:00:00

  • Giant congenital capillary hemangioma of pericranium--case report.

    abstract::The authors report a newborn male infant with a giant congenital capillary hemangioma of the pericranium. An elastic mass, measuring 6.5 x 6.9 x 3.9 cm, was located in the parieto-occipital region. Neurological examination revealed no abnormality. Angiographically, the tumor was fed symmetrically by the bilateral supe...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.30.1029

    authors: Tokuda Y,Uozumi T,Sakoda K,Yamada K,Yamanaka M,Nomura S,Hamasaki T

    更新日期:1990-12-01 00:00:00

  • Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas - A Pilot Study.

    abstract::Recurrent malignant gliomas (RMGs) are difficult to control, and no standard protocol has been established for their treatment. At our institute, we have often treated RMGs by tumor-selective particle radiation called boron neutron capture therapy (BNCT). However, despite the cell-selectivity of BNCT, brain radiation ...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.oa.2018-0111

    authors: Shiba H,Takeuchi K,Hiramatsu R,Furuse M,Nonoguchi N,Kawabata S,Kuroiwa T,Kondo N,Sakurai Y,Suzuki M,Ono K,Oue S,Ishikawa E,Michiue H,Miyatake SI

    更新日期:2018-12-15 00:00:00

  • Large dorsal internal carotid artery aneurysm--report of two cases.

    abstract::Two patients with unusually large dorsal internal carotid artery aneurysms manifesting as subarachnoid hemorrhage are described. Surgery in both cases resulted in intraoperative rupture of the sac. The outcome was poor in the first patient and excellent in the second. The importance of wide exposure of the proximal an...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.33.564

    authors: Diraz A,Kobayashi S,Gibo H,Ohsawa M

    更新日期:1993-08-01 00:00:00

  • Simultaneous bilateral vertebral artery occlusion in the lower cervical spine manifesting as bow hunter's syndrome.

    abstract::A 59-year-old male had suffered near-syncopal episodes for more than one year that occurred immediately on turning his head to the left. Cerebral magnetic resonance (MR) imaging did not detect any contributing lesions with well-developed posterior communicating arteries. Dynamic radiography of the cervical spine showe...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.48.90

    authors: Tsutsumi S,Ito M,Yasumoto Y

    更新日期:2008-02-01 00:00:00

  • Bromocriptine-induced morphological changes in cultured growth hormone-producing pituitary adenoma cells.

    abstract::Tumor tissues obtained from two patients with growth hormone-producing pituitary adenomas were cultured and treated with bromocriptine, then examined for morphological changes. Untreated tumor cells (controls) were morphologically well preserved and in terms of growth hormone secretion. Tumor cells exposed to bromocri...

    journal_title:Neurologia medico-chirurgica

    pub_type: 杂志文章

    doi:10.2176/nmc.29.6

    authors: Inoue A,Saito S,Kitamura H,Nakai O

    更新日期:1989-01-01 00:00:00